64 completed. 64 Phase 1, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 64 | Completed 64 |
| Phase 2 | 12 | Completed 12 |
Follow Sleep Initiation and Maintenance Disorders: new trials by email Literature Review of Sleep Initiation and Maintenance Disorders trials Research Report on Sleep Initiation and Maintenance Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Nutritional Supplementation on Sleep Quality Sleep Supplements, Placebo - Sleep, Sleep Quality | Phase 1 | Completed | Pharmavite LLC | 376 | 2025-05-15 | 2026-02-27 |
| A Clinical Study to Evaluate the Drug Interaction Between YZJ-1139 Tablets and Escitalopram Oxalate Tablets YZJ-1139 tablets, Escitalopram oxalate tablets, YZJ-1139 simulated tablets - Insomnia, Central Nervous System | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 24 | 2024-08-31 | 2026-06-30 |
| A Drug-drug Interaction Study of YZJ-1139 Tablets and Ticagrelor Tablets in Healthy Subjects YZJ-1139 tablets, Ticagrelor Tablets - Insomnia | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 27 | 2024-08-22 | 2026-06-30 |
| Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Severe Renal Impairment and Normal Renal Impairment YZJ-1139 - Insomnia, Renal Impairment | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 16 | 2024-06-03 | 2026-06-30 |
| Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Mild, Moderate and Normal Hepatic Impairment YZJ-1139 - Insomnia, Hepatic Impairment | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 24 | 2024-03-22 | 2024-11-04 |
| The Efficacy and Safty of FMT in Patients With CID fecal microbiota, Placebo, synbiotics - Insomnia Chronic, Fecal Microbiota Transplantation | Phase 1 / Phase 2 | Completed | Peking University Sixth Hospital | 80 | 2023-10-08 | 2026-02-27 |
| Investigating the Use of taVNS to Treat Insomnia in Individuals With Breast Cancer (taVNS-insomnia-BC) transauricular Vagus Nerve Stimulation - Breast Cancer, Insomnia | Phase 1 | Completed | University of Alabama at Birmingham | 20 | 2023-09-26 | 2026-06-18 |
| Montmorency Cherry Supplementation, Sleep, and Inflammation Montmorency cherry supplement, Control - Insomnia Chronic, Inflammation | Phase 1 / Phase 2 | Completed | Michigan State University | 34 | 2023-02-18 | 2025-09-08 |
| Mirtazapine for Chronic Insomnia in Older Adults Mirtazapine 7.5 MG Oral Tablet once daily at bedtime, Placebo oral tablet once daily at bedtime - Chronic Insomnia | Phase 1 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 60 | 2022-10-01 | 2024-08-12 |
| Cannabinol Use in Patients With Insomnia Disorder 30 mg Cannabinol (CBN), 300 mg Cannabinol (CBN), Placebo - Insomnia Disorder | Phase 1 / Phase 2 | Completed | Woolcock Institute of Medical Research | 20 | 2022-08-24 | 2024-02-06 |
| Feasibility Study of Personalized Trials to Improve Sleep Quality Melatonin 3 mg, Melatonin 0.5 mg, Cellulose placebo pill - Sleep Disturbance | Phase 1 | Completed | Northwell Health | 60 | 2022-05-11 | 2024-08-22 |
| the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets Food, HEC83518, placebo - Insomnia | Phase 1 | Completed | Sunshine Lake Pharma Co., Ltd. | 57 | 2021-01-18 | 2026-05-01 |
| The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets in Chinses Healthy Subjects HEC83518 tablets, Placebo - Insomnia | Phase 1 | Completed | Sunshine Lake Pharma Co., Ltd. | 74 | 2020-04-01 | 2026-05-01 |
| PK/PD Study of YZJ-1139 YZJ-1139, Placebo, Zolpidem - Insomnia | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 20 | 2019-03-07 | 2024-11-12 |
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of YZJ-1139 in Healthy Participants YZJ-1139, Placebo - Insomnia | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 104 | 2017-12-01 | 2025-02-10 |
| The Impact of a Combination of Bifidobacterium Longum 35624® and 1714™ Strains in Adults With Irritable Bowel Syndrome Probiotic capsule - IBS - Irritable Bowel Syndrome, Depression, Anxiety | Phase 1 / Phase 2 | Completed | PrecisionBiotics Group Ltd. | 40 | 2017-09-20 | 2020-06-09 |
| Sleep and Healthy Aging Research for Depression (SHARE-D) Study Endotoxin, Placebo - Depression in Old Age | Phase 1 | Completed | Michael Irwin, MD | 160 | 2017-08-23 | 2024-09-05 |
| A Study to Determine the Abuse Potential of Single Oral Doses of Lemborexant Compared to Zolpidem, Suvorexant and Placebo in Healthy, Non-Dependent, Recreational Sedative Users Zolpidem tablets, Suvorexant tablets, over-encapsulated, Lemborexant tablets - Insomnia Disorders | Phase 1 | Completed | Eisai Inc. | 39 | 2017-04-19 | 2020-06-29 |
| Repurposing Dexmedetomidine as an Orally Administered Sleep Therapeutic Dexmedetomidine, Saline Placebo - Sleep, Insomnia | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 15 | 2016-10-01 | 2019-10-02 |
| Effect of Background Noise on Sleep Quality NIghtingale (R) device for filtered white noise (Cambridge Sound Management, Waltham, MA) - Sleep Onset Insomnia | Phase 1 / Phase 2 | Completed | Brigham and Women's Hospital | 20 | 2016-08-01 | 2018-05-25 |
Showing 20 of 64. Sign in to see all of them.
Depression (4) · Parasomnias (4) · Anxiety Disorders (3) · Sleep Deprivation (3) · Sleep Wake Disorders (3) · Autistic Disorder (1) · Brain Concussion (1) · Breast Neoplasms (1) · Chronic Pain (1) · Cognitive Dysfunction (1) · Cough (1) · Depressive Disorder, Major (1) · Dyssomnias (1) · Fatigue Syndrome, Chronic (1)
Nervous System Diseases (64) · Sleep Disorders, Intrinsic (64) · Dyssomnias (63) · Mental Disorders (63) · Sleep Wake Disorders (61) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (6) · Neurologic Manifestations (5) · Behavior (4) · Behavioral Symptoms (4) · Pathologic Processes (3) · Respiratory Tract Diseases (3) · Chronic Disease (2) · Digestive System Diseases (2) · Disease Attributes (2)
Zolpidem (8) · suvorexant (6) · N-((1-((5-(4-fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)-4-benzofurancarboxamide (4) · zopiclone (4) · lemborexant (3) · Cognitive Behavioral Therapy (2) · Eszopiclone (2) · Melatonin (2) · Mirtazapine (2) · ramelteon (2) · (1-aminomethyl-3,4-dimethylcyclopentyl)acetic acid (1) · Administration, Sublingual (1) · Cannabinol (1) · Charcoal (1) · D-Worm (1)
Merck Sharp & Dohme LLC (7) · Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (6) · Eisai Inc. (5) · GlaxoSmithKline (4) · Eli Lilly and Company (3) · Sunshine Lake Pharma Co., Ltd. (2) · University of Utah (2) · Brigham and Women's Hospital (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Coeruleus Ltd. (1) · Duke University (1) · Duquesne University (1) · Eisai Co., Ltd. (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Idorsia Pharmaceuticals Ltd. (1)
United States (26) · China (9) · Netherlands (6) · United Kingdom (6) · Germany (4) · Canada (2) · France (2) · Israel (2) · Japan (2) · Australia (1) · Austria (1) · Denmark (1) · Finland (1) · Ireland (1) · Italy (1)
Gavin West, M.D. (2) · Alexandra Evancho, DPT (1) · Andrew Krystal, M.D. (1) · Annemiek Vermeeren, PhD (1) · Aziz Laurent (1) · Beth A Malow, MD, MS (1) · Brendon Yee, MBChB, FRACP, FCCP, PhD (1) · Camilla Hoyos, MPH, PhD (1) · Deborah Metzger, MD (1) · Dohwa Kim (1) · Dr. Daryl Bendel, MBChB (1)
PMID 18056558, PMID 19581560, PMID 21966064, PMID 22237311, PMID 22549286, PMID 24587571, PMID 25661282, PMID 26194728, PMID 26240742, PMID 31642731, PMID 32511726, PMID 33057694, PMID 35748777, PMID 37193566, PMID 37256193, PMID 37535419, PMID 37612115, PMID 40135470, PMID 40668551, PMID 41004640, PMID 41298372, PMID 41345210, PMID 41698831, PMID 42026772, PMID 42482263
R01LM012836 (1), R03MH062327 (1), R21NR009080 (1), R21NR010539 (1), R34MH070805 (1)