64 completed, 8 unknown, 3 terminated, 2 not yet recruiting. 81 Phase 1, 17 Phase 2.
Follow Sleep Initiation and Maintenance Disorders: new trials by email Literature Review of Sleep Initiation and Maintenance Disorders trials Research Report on Sleep Initiation and Maintenance Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD) ALN-6457 - Prion Disease | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 60 | 2026-10-23 | 2026-09-22 |
| PrP-targeting siRNA Safety & Mechanism Study PrP-siRNA - Prion Disease | Phase 1 | Recruiting | Broad Institute of MIT and Harvard | 45 | 2026-05-15 | 2026-10-16 |
| Mindfulness Meditation for Insomnia Instructed bedtime app-guided mindfulness meditation, Uninstructed app-guided mindfulness meditation, Sleep hygiene education - Sleep Initiation and Maintenance Disorders, Insomnia | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 30 | 2026-03-31 | 2026-06-23 |
| Morning-Evening Specific Longevity Food Supplement Morning- and evening-specific compound food supplement, Control - Aging | Phase 1 | Active not recruiting | University of Primorska | 60 | 2026-03-07 | 2026-03-11 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Impact of Nutritional Supplementation on Sleep Quality Sleep Supplements, Placebo - Sleep, Sleep Quality | Phase 1 | Completed | Pharmavite LLC | 376 | 2025-05-15 | 2026-02-27 |
| A Clinical Study to Evaluate the Drug Interaction Between YZJ-1139 Tablets and Escitalopram Oxalate Tablets YZJ-1139 tablets, Escitalopram oxalate tablets, YZJ-1139 simulated tablets - Insomnia, Central Nervous System | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 24 | 2024-08-31 | 2026-06-30 |
| A Drug-drug Interaction Study of YZJ-1139 Tablets and Ticagrelor Tablets in Healthy Subjects YZJ-1139 tablets, Ticagrelor Tablets - Insomnia | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 27 | 2024-08-22 | 2026-06-30 |
| Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Severe Renal Impairment and Normal Renal Impairment YZJ-1139 - Insomnia, Renal Impairment | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 16 | 2024-06-03 | 2026-06-30 |
| Phase Ⅰb/Ⅱ Study of HS-10506 in Chinese Participants With Insomnia Disorder HS-10506, Placebo - Insomnia Disorder | Phase 1 / Phase 2 | Unknown | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 312 | 2024-05-01 | 2024-04-23 |
| Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Mild, Moderate and Normal Hepatic Impairment YZJ-1139 - Insomnia, Hepatic Impairment | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 24 | 2024-03-22 | 2024-11-04 |
| The Efficacy and Safty of FMT in Patients With CID fecal microbiota, Placebo, synbiotics - Insomnia Chronic, Fecal Microbiota Transplantation | Phase 1 / Phase 2 | Completed | Peking University Sixth Hospital | 80 | 2023-10-08 | 2026-02-27 |
| Investigating the Use of taVNS to Treat Insomnia in Individuals With Breast Cancer (taVNS-insomnia-BC) transauricular Vagus Nerve Stimulation - Breast Cancer, Insomnia | Phase 1 | Completed | University of Alabama at Birmingham | 20 | 2023-09-26 | 2026-06-18 |
| Oral Supplement in Older Adults to Support Physical Fitness and Mental Well-being Q-actin, Placebo - Osteo-arthritis | Phase 1 | Unknown | Aberystwyth University | 50 | 2023-04-22 | 2023-05-26 |
| Comparative Pharmacokinetic (PK) Study of Ibuprofen and Diphenhydramine Hydrochloride MR Tablets in Healthy Adults Under Fasting Condition Compound ibuprofen polyrelease tablets, reference 1 (R1): Ibuprofen Tablets (Motrin IB®)reference 2 (R2): Diphenhydramine Hydrochloride Tablets (Benadryl®) - Pain, Insomnia | Phase 1 | Unknown | Overseas Pharmaceuticals, Ltd. | 16 | 2023-04-03 | 2023-02-15 |
| Montmorency Cherry Supplementation, Sleep, and Inflammation Montmorency cherry supplement, Control - Insomnia Chronic, Inflammation | Phase 1 / Phase 2 | Completed | Michigan State University | 34 | 2023-02-18 | 2025-09-08 |
| Shugan Jieyu Capsule for Insomnia Patients With Depressive Symptoms Experimental group: Shugan Jieyu Capsule combined with zolpidem, Control group: Placebo combined with zolpidem - Insomnia | Phase 1 | Unknown | Nanfang Hospital, Southern Medical University | 60 | 2022-11-30 | 2023-03-13 |
| Mirtazapine for Chronic Insomnia in Older Adults Mirtazapine 7.5 MG Oral Tablet once daily at bedtime, Placebo oral tablet once daily at bedtime - Chronic Insomnia | Phase 1 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 60 | 2022-10-01 | 2024-08-12 |
| Cannabinol Use in Patients With Insomnia Disorder 30 mg Cannabinol (CBN), 300 mg Cannabinol (CBN), Placebo - Insomnia Disorder | Phase 1 / Phase 2 | Completed | Woolcock Institute of Medical Research | 20 | 2022-08-24 | 2024-02-06 |
| Feasibility Study of Personalized Trials to Improve Sleep Quality Melatonin 3 mg, Melatonin 0.5 mg, Cellulose placebo pill - Sleep Disturbance | Phase 1 | Completed | Northwell Health | 60 | 2022-05-11 | 2024-08-22 |
Showing 20 of 81. Sign in to see all of them.
Anxiety Disorders (6) · Depression (6) · Parasomnias (4) · Sleep Deprivation (4) · Sleep Wake Disorders (4) · Chronic Pain (2) · Creutzfeldt-Jakob Syndrome (2) · Gerstmann-Straussler-Scheinker Disease (2) · Insomnia, Fatal Familial (2) · Pain (2) · Prion Diseases (2) · Psychological Well-Being (2) · Stress Disorders, Post-Traumatic (2) · Ageusia (1)
Nervous System Diseases (81) · Sleep Disorders, Intrinsic (81) · Dyssomnias (80) · Mental Disorders (80) · Sleep Wake Disorders (77) · Pathological Conditions, Signs and Symptoms (13) · Signs and Symptoms (10) · Neurologic Manifestations (9) · Behavior (8) · Behavioral Symptoms (6) · Brain Diseases (4) · Neurocognitive Disorders (4) · Pathologic Processes (4) · Central Nervous System Diseases (3) · Chronic Disease (3)
Zolpidem (10) · suvorexant (6) · N-((1-((5-(4-fluorophenyl)-2-methyl-4-thiazolyl)carbonyl)-2-piperidinyl)methyl)-4-benzofurancarboxamide (5) · zopiclone (4) · Eszopiclone (3) · lemborexant (3) · Cognitive Behavioral Therapy (2) · Melatonin (2) · Mirtazapine (2) · ramelteon (2) · (1-aminomethyl-3,4-dimethylcyclopentyl)acetic acid (1) · Acupuncture Therapy (1) · Administration, Sublingual (1) · Cannabinol (1) · Charcoal (1)
Merck Sharp & Dohme LLC (7) · Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (6) · Eisai Inc. (5) · GlaxoSmithKline (5) · Eli Lilly and Company (4) · Brigham and Women's Hospital (2) · Sunshine Lake Pharma Co., Ltd. (2) · University of Utah (2) · Aberystwyth University (1) · Advanced Pain and Rehab Specialists (1) · All Natural Medicine Clinic, LLC (1) · Beth Israel Deaconess Medical Center (1) · Broad Institute of MIT and Harvard (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Changchun University of Chinese Medicine (1)
United States (33) · China (13) · United Kingdom (7) · Netherlands (6) · Germany (5) · Canada (2) · France (2) · Israel (2) · Japan (2) · Australia (1) · Austria (1) · Denmark (1) · Finland (1) · Hungary (1) · Ireland (1)
Gavin West, M.D. (2) · Alexandra Evancho, DPT (1) · Amanda Jane J Lloyd, PhD, BSc (1) · Andrew Krystal, M.D. (1) · Annemiek Vermeeren, PhD (1) · Aziz Laurent (1) · Beth A Malow, MD, MS (1) · Bin Zhang, MD & PhD (1) · Brendon Yee, MBChB, FRACP, FCCP, PhD (1) · Camilla Hoyos, MPH, PhD (1) · Claire C. Bourguet, Ph.D. (1)
PMID 18056558, PMID 19581560, PMID 21966064, PMID 22237311, PMID 22549286, PMID 24587571, PMID 25661282, PMID 26194728, PMID 26240742, PMID 31642731, PMID 32511726, PMID 32807158, PMID 33057694, PMID 33146953, PMID 34918637, PMID 35748777, PMID 37193566, PMID 37256193, PMID 37535419, PMID 37612115, PMID 40135470, PMID 40421033, PMID 40668551, PMID 41004640, PMID 41107798, PMID 41298372, PMID 41345210, PMID 41698831, PMID 41904400, PMID 42026772, PMID 42482263
K23AT012475 (1), OT2NS138339 (1), R01LM012836 (1), R03MH062327 (1), R21NR009080 (1), R21NR010539 (1), R34MH070805 (1)