16 completed, 7 recruiting, 3 unknown, 2 active not recruiting. 9 Not applicable, 5 Phase 2, 4 Phase 1, 1 Phase 3.
Follow Prion Diseases: new trials by email Literature Review of Prion Diseases trials Research Report on Prion Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial of ALN-6457 in Adult Participants With Symptomatic Prion Disease (PrD) ALN-6457 - Prion Disease | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 60 | 2026-10-23 | 2026-09-22 |
| PROSPECT Registry for Individuals at Risk for Genetic Prion Disease Prion Diseases | Recruiting | Brian Appleby | 2000 | 2026-08-25 | 2026-09-16 | |
| PrP-targeting siRNA Safety & Mechanism Study PrP-siRNA - Prion Disease | Phase 1 | Recruiting | Broad Institute of MIT and Harvard | 45 | 2026-05-15 | 2026-10-16 |
| Efavirenz for the Treatment of Creutzfeldt-Jakob Disease Efavirenz, Placebo - Creutzfeldt-Jakob Disease | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 246 | 2026-04-14 | 2026-09-03 |
| Clinical and Jaw Tracking Assessment Following Intra-articular Injection of PRP and HA in TMJ Disc Displacement With Reduction Hyaluronic Acid (HA) and Platelet rich plasma - Temporomandibular Joint Disc Displacement, With Reduction | Not applicable | Completed | Mansoura University | 20 | 2025-07-01 | 2026-09-08 |
| Platelet-Rich Plasma Injections From Cord Blood + Penile Traction vs. Penile Traction Alone in Patients With Peyronie's Disease. Open-label, Single-center Randomized Study Injection - Peyronie Disease, Penile Curvature | Not applicable | Recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 42 | 2025-05-28 | 2025-06-08 |
| Mulligan and Maitland Techniques in Post PRP Knee Osteoarthritis Mulligan(MWM) MobilizationTechnique, Maitland Mobilization technique - Knee Osteoarthritis | Not applicable | Completed | Riphah International University | 36 | 2024-12-15 | 2025-07-04 |
| FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases Alpha-Thalassemia, Beta-Thalassemia | Unknown | xCures | 1000 | 2024-06-10 | 2024-11-14 | |
| PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717 ION717, Placebo - Prion Disease | Phase 1 / Phase 2 | Active not recruiting | Ionis Pharmaceuticals, Inc. | 85 | 2024-01-04 | 2026-09-18 |
| Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers Jumpstart Guide - Dementia, Dementia, Vascular | Not applicable | Active not recruiting | University of Washington | 1802 | 2023-09-11 | 2026-09-21 |
| Platelet- Rich Plasma Injection Platelet Rich Plasma - Wound Healing, Anal Fistula | Not applicable | Completed | Mansoura University | 100 | 2023-07-14 | 2025-03-25 |
| A Natural History Study of Preclinical Genetic Creutzfeldt-Jakob Disease (CJD) Creutzfeldt-Jakob Disease (CJD) | Recruiting | Tel-Aviv Sourasky Medical Center | 126 | 2022-06-01 | 2023-02-28 | |
| Teleneurology Assessment Program for Creutzfeldt-Jakob Disease Teleneurology Assessment - Creutzfeldt-Jakob Disease (CJD) | Prion Disease | Recruiting | University Hospitals Cleveland Medical Center | 200 | 2022-01-25 | 2026-09-25 | |
| CLIME-CJD: A Multimodal Study No Interventions - Creutzfeldt-Jakob Disease (CJD) | Prion Disease | Enrolling by invitation | First Affiliated Hospital of Fujian Medical University | 150 | 2022-01-01 | 2026-05-15 | |
| Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction Injection into olfactory cleft - Olfactory Disorder, Olfaction Disorders | Not applicable | Completed | Stanford University | 30 | 2021-06-22 | 2023-03-13 |
| Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults cAd3-Marburg, cAd3-EBO-S - Ebola Virus Disease, Marburg Virus Disease | Phase 1 | Completed | Albert B. Sabin Vaccine Institute | 32 | 2021-01-06 | 2022-08-03 |
| Condensed Nanofat Grafting for Treatment of Androgenetic Alopecia Nanofat grafting - Androgenic Alopecia | Not applicable | Completed | Jinan University Guangzhou | 10 | 2019-02-27 | 2021-02-21 |
| Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Methods autologous adipose tissue transfer, PRP injections - Osteo Arthritis Knee, Knee Osteoarthritis | Phase 2 | Unknown | Rehasport Clinic | 60 | 2018-07-30 | 2020-03-25 |
| OBSERVE: Biomarkers in Individuals at Risk for Prion Disease CJD (Creutzfeldt Jakob Disease), Prion Diseases | Recruiting | Massachusetts General Hospital | 150 | 2017-12-01 | 2026-08-13 | |
| Leukocyte-Poor Platelet-Rich Plasma Reduces Pain Symptoms in the Treatment of the Lateral Epicondylitis effectiveness of platelet-rich plasma (PRP) in treating lateral epicondylar tendinopathy (LET) - Tennis Elbow, Lateral Epicondylitis | Not applicable | Completed | Rehasport Clinic | 72 | 2017-01-02 | 2025-03-03 |
Showing 20 of 30. Sign in to see all of them.
Insomnia, Fatal Familial (17) · Creutzfeldt-Jakob Syndrome (13) · Dementia (4) · Acquired Immunodeficiency Syndrome (2) · Alopecia (2) · Alzheimer Disease (2) · Gerstmann-Straussler-Scheinker Disease (2) · Hepatitis B (2) · Hepatitis C (2) · Huntington Disease (2) · Osteoarthritis, Knee (2) · Acquired angioedema (1) · Amyloidosis (1) · Amyotrophic Lateral Sclerosis (1)
Infections (30) · Central Nervous System Diseases (29) · Central Nervous System Infections (29) · Nervous System Diseases (29) · Neurodegenerative Diseases (25) · Dyssomnias (17) · Sleep Disorders, Intrinsic (17) · Sleep Initiation and Maintenance Disorders (17) · Sleep Wake Disorders (17) · Brain Diseases (15) · Mental Disorders (15) · Neurocognitive Disorders (15) · Dementia (11) · Pathological Conditions, Signs and Symptoms (7)
Blood Specimen Collection (2) · Quinacrine (2) · Autopsy (1) · Hyaluronic Acid (1) · Injections (1) · Mesotherapy (1) · Phosphoglycerate Kinase (1) · efavirenz (1)
Mansoura University (2) · Rehasport Clinic (2) · Albert B. Sabin Vaccine Institute (1) · Brian Appleby (1) · Broad Institute of MIT and Harvard (1) · Faculty Hospital Kralovske Vinohrady (1) · First Affiliated Hospital of Fujian Medical University (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Ionis Pharmaceuticals, Inc. (1) · Jinan University Guangzhou (1) · Mario Negri Institute for Pharmacological Research (1) · Massachusetts General Hospital (1) · Medical Research Council (1) · NHS Blood and Transplant (1) · Peking University Third Hospital (1)
United States (12) · China (3) · Israel (3) · Italy (3) · United Kingdom (3) · Egypt (2) · Germany (2) · Poland (2) · Australia (1) · Austria (1) · Canada (1) · France (1) · Japan (1) · Pakistan (1) · Slovakia (1)
Anna M Molesworth, PhD (1) · Athanasios J Stefanis (1) · Brian S Appleby, M.D. (1) · Bruce L. Miller, MD (1) · Cameron F Ousbey, MSc (1) · David Hoover, MD (1) · Eric V Minikel, PhD (1) · Erin Kross, MD (1) · Janet Darbyshire, MBChB, FRCP (1) · Joanna Walecka, MD, PhD (1) · John Collinge, MD, FRCP (1) · Josef T Prchal, MD (1) · Li Xiaogang (1) · Michael Geschwind, MD, PhD (1)
PMID 1538192, PMID 15577929, PMID 16375711, PMID 16921694, PMID 17983892, PMID 18638001, PMID 2231932, PMID 23421851, PMID 24122181, PMID 25426834, PMID 26707828, PMID 27298777, PMID 32098855, PMID 32434498, PMID 36507615, PMID 37069531, PMID 38106680, PMID 38896810, PMID 39084863, PMID 39386300, PMID 41579194, PMID 8237108
2023 (1), OT2NS138339 (1), P01AG021601 (1), R01AG078169 (1)