52 completed, 14 terminated, 14 unknown, 7 recruiting. 95 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 95 | Completed 52, Terminated 14, Unknown 14, Recruiting 7, Withdrawn 5, Active not recruiting 2, Not yet recruiting 1 |
Follow Sleep Apnea, Obstructive: new trials by email Literature Review of Sleep Apnea, Obstructive trials Research Report on Sleep Apnea, Obstructive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin - Obstructive Sleep Apnea (OSA) | Phase 4 | Recruiting | Sairam Parthasarathy | 2400 | 2026-09-04 | 2026-10-19 |
| INFORMing Patients With Oximetry Data to Improve MAD Engagement Narval MRD device, MyNarval intervention (Narval CC MAD + O2 ring + MyNarval smartphone application), - Obstructive Sleep Apnea (OSA) | Phase 4 | Not yet recruiting | ResMed | 120 | 2026-06-01 | 2026-05-04 |
| Endotype DIrected Treatment for OSA in Down Syndrome ato-oxy, Oxygen - Obstructive Sleep Apnea (OSA), Down Syndrome | Phase 4 | Recruiting | University of Arizona | 200 | 2026-03-14 | 2026-09-03 |
| Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy Remimazolam and Propofol, Propofol, Midazolam and propofol - Sedative Effect During Drug-induced Sleep Endoscopy, Obstructive Sleep Apnea (OSA) | Phase 4 | Active not recruiting | Dan Liu | 174 | 2025-03-01 | 2026-02-24 |
| Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA Dexmedetomidine-esketamine combination, Placebo - Obstructive Sleep Apnea, Surgery | Phase 4 | Completed | Peking University First Hospital | 100 | 2024-09-11 | 2026-09-04 |
| Muscle Relaxation for Pediatric Adenotonsillectomy Rocuronium, Sugammadex, Anesthesia without neuromuscular blockade - Tonsillectomy | Phase 4 | Completed | University of Texas Southwestern Medical Center | 172 | 2024-04-10 | 2025-07-28 |
| Impact GLP-1 Agonists Following Bariatric GLP-1 receptor agonist - Morbid Obesity, Metabolic Syndrome | Phase 4 | Recruiting | University of Missouri-Columbia | 150 | 2024-02-01 | 2026-10-21 |
| CPAP Effect on the Polycythemia in Patients With Obstructive Sleep Apnea Continuous positive airway pressure, Conventional pharmacological treatment, Sleep ,diet and life style recomendations - Sleep Apnea, Obstructive, Polycythemia | Phase 4 | Recruiting | Hospital Universitario Ramon y Cajal | 182 | 2023-11-01 | 2025-09-17 |
| Zolpidem on CPAP Acclimatization in OSA Zolpidem, Placebo - Obstructive Sleep Apnea | Phase 4 | Unknown | Siriraj Hospital | 30 | 2023-10-15 | 2023-10-16 |
| Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA Eszopiclone 3 mg, Placebo - Obstructive Sleep Apnea, Insomnia | Phase 4 | Completed | University of Sao Paulo General Hospital | 60 | 2023-08-24 | 2026-05-29 |
| Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA) Melatonin 3 MG Oral Tablet - Obstructive Sleep Apnea of Adult | Phase 4 | Recruiting | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 50 | 2023-06-22 | 2026-04-01 |
| Evaluation of Trazodone in OSA-MCI Trazodone, Placebo - Mild Cognitive Impairment, Obstructive Sleep Apnea | Phase 4 | Active not recruiting | Chinese University of Hong Kong | 134 | 2022-05-10 | 2026-01-06 |
| Dental Appliance to Treat SDB in Children Vivos Grow/Vivos Way Device - Snoring, Apnea, Obstructive | Phase 4 | Unknown | Vivos BioTechnologies, Inc. | 50 | 2022-05-03 | 2022-12-22 |
| Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea Patients Spironolactone, Placebo - Obstructive Sleep Apnea | Phase 4 | Withdrawn | University of Michigan | 2022-03-01 | 2022-04-19 | |
| Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications Sugammadex 100 MG/ML [Bridion] - Respiratory Complication, Obstructive Sleep Apnea | Phase 4 | Completed | University of California, Los Angeles | 12248 | 2022-02-18 | 2025-07-29 |
| Ketorolac on Postoperative Pain Reduction in Pediatric Patients with Adenotonsillectomy Ketorolac - Adenotonsillar Hypertrophy, Obstructive Sleep Apnea | Phase 4 | Completed | St. Louis University | 142 | 2022-02-08 | 2025-02-03 |
| First Line Obstructive Sleep Apnea Treatment Study Mandibular advancement device (MAD), Continuous positive airway pressure (CPAP) - Obstructive Sleep Apnea | Phase 4 | Completed | University Hospital, Antwerp | 136 | 2021-11-09 | 2025-02-14 |
| Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study Solriamfetol, Placebo - Excessive Daytime Sleepiness, Obstructive Sleep Apnea | Phase 4 | Completed | Axsome Therapeutics, Inc. | 59 | 2021-05-17 | 2026-01-26 |
| Optimal Dosage of Acetazolamide for OSA Treatment Acetazolamide, Placebo - Obstructive Sleep Apnea | Phase 4 | Completed | University Hospital, Antwerp | 91 | 2021-04-20 | 2025-09-24 |
| Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea Dexmedetomidine, Placebo - Obstructive Sleep Apnea, Analgesia | Phase 4 | Completed | Peking University First Hospital | 152 | 2021-01-29 | 2022-12-13 |
Showing 20 of 95. Sign in to see all of them.
Sleep Apnea Syndromes (19) · Hypertension (7) · Apnea (5) · Disorders of Excessive Somnolence (4) · Hypoxia (4) · Agnosia (3) · Snoring (3) · Cardiovascular Diseases (2) · Metabolic Syndrome (2) · Obesity (2) · Obesity, Morbid (2) · Pain, Postoperative (2) · Sleep Initiation and Maintenance Disorders (2) · Sleep Wake Disorders (2)
Dyssomnias (95) · Nervous System Diseases (95) · Respiration Disorders (95) · Respiratory Tract Diseases (95) · Sleep Disorders, Intrinsic (95) · Sleep Wake Disorders (93) · Apnea (90) · Sleep Apnea Syndromes (76) · Pathological Conditions, Signs and Symptoms (28) · Signs and Symptoms (23) · Cardiovascular Diseases (12) · Mental Disorders (12) · Vascular Diseases (12) · Neurologic Manifestations (11) · Signs and Symptoms, Respiratory (9)
Continuous Positive Airway Pressure (10) · Dexmedetomidine (5) · Propofol (5) · Acetazolamide (4) · Occlusal Splints (4) · Sugammadex (4) · Donepezil (3) · Eszopiclone (3) · Modafinil (3) · Budesonide (2) · Drug Delivery Systems (2) · Ketorolac (2) · Mometasone Furoate (2) · Neostigmine (2) · Saline Solution (2)
University Hospital, Antwerp (4) · University of California, San Diego (4) · University of Sao Paulo (4) · University of Chicago (3) · University of Zurich (3) · Associacao Fundo de Incentivo a Psicofarmcologia (2) · Associação Fundo de Incentivo à Pesquisa (2) · Children's Hospital Medical Center, Cincinnati (2) · Emory University (2) · Fédération Française de Pneumologie (2) · Hospital de Clinicas de Porto Alegre (2) · Inspire Medical Systems, Inc. (2) · Peking University First Hospital (2) · Regional Hospital Holstebro (2) · University Hospital, Grenoble (2)
United States (35) · Brazil (12) · Belgium (7) · Canada (7) · China (4) · France (4) · Italy (4) · Switzerland (4) · Denmark (2) · Germany (2) · Netherlands (2) · South Korea (2) · Spain (2) · Turkey (Türkiye) (2) · Australia (1)
Konrad E Bloch, MD (3) · Armin Steffen, PD Dr. med. (2) · Christopher J Lettieri, MD (2) · Clemens Heiser, Dr. med. (2) · David L Steward, MD (2) · Denis Martinez, MD, PhD (2) · Erling B Pedersen, Professor (2) · Olivier Vanderveken, MD, PhD (2) · Alister Bates, PhD (1) · Andrew Goldberg, MD (1) · Andrew Wheeler, MD (1) · Andrzej Tykarski, Prof (1) · Bertram Pitt, MD (1)
PMID 10450601, PMID 10678860, PMID 10908222, PMID 10940788, PMID 11208620, PMID 11422885, PMID 11587154, PMID 12748199, PMID 14500166, PMID 15187032, PMID 16376782, PMID 16494088, PMID 16579514, PMID 17452537, PMID 17494787, PMID 17496462, PMID 17556718, PMID 17920917, PMID 17921053, PMID 17936040, PMID 17975198, PMID 1798888, PMID 18172212, PMID 18198262, PMID 18292756, PMID 18347202, PMID 18404673, PMID 18413499, PMID 18452788, PMID 18458174, PMID 18539753, PMID 18584016, PMID 18595959, PMID 18647805, PMID 18663661, PMID 18710420, PMID 18788656, PMID 19101028, PMID 19171788, PMID 19225527, PMID 19249441, PMID 19357147, PMID 19567493, PMID 19920270, PMID 20016520, PMID 20051221, PMID 20411620, PMID 20448096, PMID 20522795, PMID 20642206
2019 (1), R01HL075079 (1), U19AI057229 (1)