21 completed, 2 terminated, 2 unknown, 2 withdrawn. 27 Phase 2, 7 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 27 | Completed 21, Terminated 2, Unknown 2, Withdrawn 2 |
| Phase 1 | 7 | Completed 6, Terminated 1 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
Follow Sinusitis: new trials by email Literature Review of Sinusitis trials Research Report on Sinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute Rhinosinusitis Nitric Oxide Releasing Solution, Nasal spray with isotonic saline - Recurrent Acute Rhinosinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 162 | 2024-01-16 | 2026-04-22 |
| A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps. 300mg of TQH2722 injection, 600mg of TQH2722 injection, TQH2722 injection matching placebo - Sinusitis | Phase 2 | Completed | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 160 | 2023-12-28 | 2026-11-10 |
| A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal Polyps Verekitug (UPB-101), Placebo - Chronic Rhinosinusitis With Nasal Polyps | Phase 2 | Completed | Upstream Bio Inc. | 81 | 2023-12-18 | 2026-09-18 |
| A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps 611, Placebo - Sinusitis, Nasal Polyps | Phase 2 | Unknown | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 90 | 2023-06-30 | 2024-01-12 |
| Dupilumab in CRSsNP Dupilumab SAR231893, Placebo - Chronic Rhinosinusitis Without Nasal Polyps, Sinusitis | Phase 2 | Completed | Sanofi | 71 | 2020-12-02 | 2026-07-30 |
| Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) dupilumab, placebo - Chronic Sinusitis | Phase 2 | Completed | Johns Hopkins University | 33 | 2020-10-15 | 2025-11-03 |
| Investigating the Effect of Herbal Medicine Nasal Irrigation on Treatment of Chronic Rhinitis and Sinusitis Taiwan Scientific" noninvasive blood pressure meter TS-0411, Meridian Energy Analysis Device(MEAD), bacteria culture - Nasal Disease | Phase 2 / Phase 3 | Unknown | Chang Gung Memorial Hospital | 250 | 2019-12-31 | 2020-06-22 |
| Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS) Nitric Oxide, Budesonide - Chronic Sinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 56 | 2019-10-27 | 2022-06-30 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| SynRinse Irrigation Pilot (SIP) Trial Synrinse - Sinusitis, Chronic, Cystic Fibrosis With Other Manifestations | Phase 1 / Phase 2 | Completed | University of Washington | 30 | 2017-06-06 | 2018-10-17 |
| The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis Silver Colloid, Saline - Rhinosinusitis | Phase 1 / Phase 2 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 22 | 2015-12-10 | 2019-11-15 |
| Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis Budesonide - Rhinosinusitis | Phase 1 / Phase 2 | Completed | Pari Pharma GmbH | 19 | 2015-10-27 | 2022-04-12 |
| Topical Irrigation Therapy for CRS Quinine Sulfate, Placebo - Rhinitis, Sinusitis | Phase 1 / Phase 2 | Terminated | University of Pennsylvania | 10 | 2015-10-01 | 2019-03-13 |
| Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia dexpramipexole - Chronic Sinusitis With Nasal Polyps and Eosinophilia | Phase 2 | Completed | Knopp Biosciences | 20 | 2014-08-01 | 2021-05-18 |
| Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi Budesonide - Rhinosinusitis, Chronic Polyposis | Phase 1 / Phase 2 | Completed | Pari Pharma GmbH | 14 | 2013-08-28 | 2022-04-12 |
| Evaluation of Inhaled Treatment in Sinusitis methylprednisolone, Budesonide - Sinusitis | Phase 2 / Phase 3 | Completed | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 50 | 2013-07-01 | 2014-01-27 |
| Trial of Directed High-dose Nasal Steroids on Residual Smell Loss in Sinus Patients After Sinus Surgery Budesonide Respules - Olfaction Disorders, Sinusitis | Phase 2 | Withdrawn | University of North Carolina, Chapel Hill | 2013-03-01 | 2016-04-06 | |
| Efficacy Study of SIMVASTATIN to Treat Chronic Rhinosinusitis After Failure of Optimal Treatment SIMVASTATIN - Rhinosinusitis | Phase 2 | Terminated | Centre hospitalier de l'Université de Montréal (CHUM) | 7 | 2012-08-01 | 2015-07-13 |
| Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial placebo, doxycycline 100 mg - Chronic Rhinosinusitis, Nasal Polyps | Phase 2 | Completed | University Hospital, Ghent | 33 | 2011-11-22 | 2018-06-15 |
| Manuka Honey Irrigation After Sinus Surgery Manuka Honey, Saline Irrigation - Sinusitis | Phase 1 / Phase 2 | Completed | St. Paul's Hospital, Canada | 78 | 2011-06-01 | 2013-12-04 |
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Rhinosinusitis (10) · Nasal Polyps (4) · Paranasal Sinus Diseases (3) · Asthma (2) · Bronchiolitis Obliterans Syndrome (2) · Nose Diseases (2) · Rhinitis (2) · AIDS-Related Complex (1) · Acquired Immunodeficiency Syndrome (1) · Cystic Fibrosis (1) · Eosinophilia (1) · HIV Infections (1) · Olfaction Disorders (1) · Otorhinolaryngologic Diseases (1)
Infections (27) · Respiratory Tract Infections (27) · Otorhinolaryngologic Diseases (26) · Respiratory Tract Diseases (26) · Nose Diseases (25) · Paranasal Sinus Diseases (24) · Rhinitis (10) · Pathological Conditions, Signs and Symptoms (6) · Immune System Diseases (5) · Lung Diseases (5) · Bronchial Diseases (4) · Lung Diseases, Obstructive (4) · Pathological Conditions, Anatomical (4) · Polyps (3)
Budesonide (5) · Sodium Chloride (2) · dupilumab (2) · Azithromycin (1) · BID protein, human (1) · Beclomethasone (1) · Blood Specimen Collection (1) · Dexpramipexole (1) · Doxycycline (1) · Guaifenesin (1) · Hematologic Tests (1) · Methylprednisolone (1) · Nitric Oxide (1) · Pseudoephedrine (1) · Quinine (1)
Pari Pharma GmbH (2) · Sanotize Research and Development corp. (2) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Chang Gung Memorial Hospital (1) · Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Entellus Medical, Inc. (1) · GlaxoSmithKline (1) · HaEmek Medical Center, Israel (1) · Johns Hopkins University (1) · Knopp Biosciences (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Ochsner Health System (1) · Pfizer (1)
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Adam M Zanation, MD (1) · Amin Javer, MD (1) · Amin R Javer, MD, FRCSC (1) · Andrew M Wilson (1) · Claus Bachert, MD, PhD (1) · Coralie Colbrant, PT (1) · Greg Davis, MD (1) · Gregory Reychler, PhD (1) · J Zurlo (1) · JA McCutchan (1) · James Stankiewicz, MD (1) · Jody Tversky (1) · Keith Moore, PharmD (1)
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