24 completed, 1 unknown, 1 withdrawn. 9 Phase 1, 5 Not applicable, 4 Phase 2, 4 Phase 3, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 9 |
| Not applicable | 5 | Completed 5 |
| Phase 2 | 4 | Completed 3, Withdrawn 1 |
| Phase 3 | 4 | Completed 3, Unknown 1 |
| Phase 4 | 3 | Completed 3 |
Follow Guaifenesin: new trials by email Literature Review of Guaifenesin trials Research Report on Guaifenesin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction Clomiphene Citrate., Guaifenesin, Estradiol (E2) - Female Infertility, Anovulatory Infertility | Not applicable | Completed | Yuzuncu Yil University | 90 | 2022-01-06 | 2026-02-10 |
| A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms Tablet paracetamol, guaifenesin and phenylephrine HCL, Vicks Active SymptoMax Plus powder for oral solution - Bioequivalence, Healthy Volunteers | Phase 1 | Completed | Johnson & Johnson Consumer and Personal Products Worldwide | 72 | 2017-07-03 | 2018-07-06 |
| A Non-Interventional Safety Study of Balsamic Bactrim Guaifenesin, Sulfamethoxazole, Trimethoprim - Bronchitis | Completed | Hoffmann-La Roche | 52 | 2016-11-15 | 2017-11-07 | |
| A Safety Study of Balsamic Bactrim in Pediatric Participants With Acute Bronchitis Guaifenesin, Sulfamethoxazole, Trimethoprim - Bronchitis | Completed | Hoffmann-La Roche | 51 | 2016-11-10 | 2019-12-13 | |
| Mucinex® for Treatment of Filamentary Keratitis Mucinex® - Filamentary Keratitis | Not applicable | Completed | Massachusetts Eye and Ear Infirmary | 15 | 2016-09-01 | 2020-02-19 |
| Bioequivalence Study of Guaifenesin and Pseudoephedrine Hydrochloride Extended Release Tablets 1200/120 mg Under Fasting Conditions Guaifenesin and Pseudoephedrine Hydrochloride Extended Release Tablets 1200/120 mg - Healthy | Phase 1 | Completed | Dr. Reddy's Laboratories Limited | 80 | 2014-12-01 | 2018-10-15 |
| Single Dose Trial of Extended Release Combination Tablet Codeine and Guaifenesin IR Tablet under Fasted conditions, ER Tablet under Fed Conditions, ER Tablet under Fasted Conditions - Cough | Phase 1 | Completed | Nexgen Pharma, Inc | 26 | 2014-06-01 | 2015-04-15 |
| Mucinex® ER 600 mg Bi-layer Tablet Versus Guaifenesin Immediate Release (IR) 200 mg q4h Mucinex® - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser Inc. | 30 | 2013-06-02 | 2019-06-17 |
| Mucinex® ER 600 mg Bi-Layer Tablet Fed and Fasted Mucinex® - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser LLC | 36 | 2013-05-29 | 2019-03-27 |
| Comparison Between Oxomemazine, Guaifenesin and Potassium Iodate Versus Guaifenesin Monotherapy in Acute Cough Treatment Syrup of oxomemazine, guaifenesin and potassium iodate, Syrup of guaifenesin - Cough | Phase 3 | Completed | EMS | 260 | 2012-10-01 | 2019-04-17 |
| Warming Sensation Intensity and Acceptability of the Flavour, Local Tolerability of Paracetamol 500 mg + Phenylephrine 10mg + Guaifenesin 200 mg Syrup in Patients Suffering a Upper Respiratory Tract Infection (URTI) IFF flavor 316 282, Paracetamol , Phenylephrine, Guaifenesin - Upper Respiratory Infections | Phase 3 | Completed | Novartis | 51 | 2012-03-01 | 2013-11-11 |
| Exploratory Efficacy Study of Guaifenesin in Upper Back Pain Guaifenesin, Placebo - Upper Back Pain | Not applicable | Completed | GlaxoSmithKline | 78 | 2012-02-01 | 2014-06-03 |
| Effectiveness Study of Integrative Treatment for Pediatric Pneumonia Fuxiong San, Xiyanping injection, Ribavirin Injection - Pneumonia | Not applicable | Completed | Liaoning University of Traditional Chinese Medicine | 451 | 2011-12-01 | 2014-02-24 |
| Study to Evaluate the Pharmacokinetics of Mucinex® 1200 mg Extended-Release Tablet Mucinex® - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser LLC | 24 | 2011-10-11 | 2019-02-28 |
| Safety and Efficacy of Mucinex and IR Guaifenesin the Treatment of Symptoms of Acute Upper Respiratory Tract Infections Mucinex, Immediate-release Guaifenesin, Placebo - Acute Upper Respiratory Tract Infection | Phase 2 / Phase 3 | Completed | Reckitt Benckiser LLC | 2810 | 2011-09-01 | 2013-11-14 |
| The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study Placebo, Guaifenesin - Chronic Rhinitis | Phase 2 | Completed | Virginia Commonwealth University | 30 | 2011-05-01 | 2020-04-24 |
| Study of Count Coughs in Subjects With Acute Upper Respiratory Tract Infections Placebo, Guaifenesin, Buckwheat Honey - Infection | Not applicable | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 265 | 2010-01-01 | 2013-02-25 |
| Mucinex Exploratory Cold Study guaifenesin (Mucinex), placebo - Common Cold | Phase 2 | Completed | Reckitt Benckiser Inc. | 378 | 2009-12-01 | 2020-12-30 |
| Safety and Efficacy Study of Guaifenesin and Pseudoephedrine for Symptomatic Therapy to Treat Acute RTI Guaifenesin, Placebo - Acute Upper Respiratory Track Infection | Phase 4 | Completed | Reckitt Benckiser Inc. | 1179 | 2009-10-01 | 2020-12-30 |
| Study to Evaluate the Pharmacokinetics of Mucinex 600 mg Extended-release Bi-layer Tablet in Healthy Volunteers Mucinex® ER 600 mg - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser Inc. | 30 | 2009-06-04 | 2019-02-28 |
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Bronchitis (3) · Common Cold (2) · Cough (2) · Rhinosinusitis (2) · Sinusitis (2) · AIDS-Related Complex (1) · Acquired Immunodeficiency Syndrome (1) · Back Pain (1) · HIV Infections (1) · Infections (1) · Infertility, Female (1) · Influenza, Human (1) · Pneumonia (1) · Respiratory Tract Infections (1) · Rhinitis, Allergic (1)
Reckitt Benckiser Inc. (5) · Reckitt Benckiser LLC (4) · Hoffmann-La Roche (2) · Adams Respiratory Therapeutics (1) · Dr. Reddy's Laboratories Limited (1) · EMS (1) · GlaxoSmithKline (1) · Johnson & Johnson Consumer and Personal Products Worldwide (1) · Liaoning University of Traditional Chinese Medicine (1) · Mantecorp Industria Quimica e Farmaceutica Ltd. (1) · Massachusetts Eye and Ear Infirmary (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Nexgen Pharma, Inc (1) · Novartis (1) · Virginia Commonwealth University (1)
United States (10) · Peru (2) · Brazil (1) · Canada (1) · China (1) · India (1) · Jordan (1) · Russia (1) · Turkey (Türkiye) (1)
Dr. K. Krishna Moorthy, MBBS (1) · Elisabeth Kruse, PhD (1) · Felipe Pinho, MD (1) · Gamze K Karababa (1) · Helmut Albrecht, M.D. (1) · J Zurlo (1) · JA McCutchan (1) · Jane Garbutt, MB, ChB (1) · Kelley Dodson, M.D. (1) · Reza Dana, M.D,MPH,M.Sc (1) · Xuefeng Wang, Ph.D. (1) · Zhenqi Wu (1)
PMID 30832720, PMID 21844413, PMID 22337680, PMID 23270519, PMID 24003241, PMID 28761581
U01AI064655 (1)