52 completed, 17 unknown, 7 withdrawn, 6 recruiting. 27 Not applicable, 15 Phase 4, 10 Phase 2, 8 Phase 3, 6 Phase 1.
Follow Rhinosinusitis: new trials by email Literature Review of Rhinosinusitis trials Research Report on Rhinosinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers Quinton Medical Nasal Health Baby® - Nasal Congestion, Common Cold | Not yet recruiting | Laboratoires Quinton International S.L. | 83 | 2026-11-01 | 2026-10-13 | |
| Observational Study of RHINOSEDAL in Acute Nasal Obstruction RHINOSEDAL - Nasal Obstruction, Common Cold | Not yet recruiting | Laboratoires Elerte | 126 | 2026-10-15 | 2026-06-02 | |
| Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI) Respiratory Tract Infection, Smell Disorder | Recruiting | National Institute on Deafness and Other Communication Disorders (NIDCD) | 80 | 2026-10-01 | 2026-10-09 | |
| Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis: Bee Venom Phonophoresis, Standard Care (oral decongestants + saline nasal irrigation) - Chronic Sinusitis, Acute Sinusitis | Not applicable | Not yet recruiting | Sinai University | 30 | 2026-08-15 | 2026-08-04 |
| A Phase 1 Study of Cizutamig in IgE Mediated Diseases Cizutamig - IgE-Mediated Hypersensitivity, IgE Mediated Food Allergy | Phase 1 | Withdrawn | Candid Therapeutics | 2026-04-01 | 2026-07-22 | |
| RhinAV_Evaluation of Treatments for Acute Viral Rhinitis, Rhinosinusitis, and Rhinopharyngitis PIR, NS, NHE - Rhinitis Acute, Rhinitis Viral | Not applicable | Recruiting | University Hospital, Clermont-Ferrand | 150 | 2026-02-25 | 2026-06-15 |
| Herbal Tea Extract for Management of Rhinosinusitis mango leaves extract, local steroids, nasal saline - Rhino Sinusitis | Not applicable | Completed | Deraya University | 30 | 2025-11-20 | 2026-04-16 |
| The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult Patients Raphamin, Placebo - Rhinosinusitis, Rhinosinusitis Acute | Phase 3 | Recruiting | Materia Medica Holding | 552 | 2025-04-03 | 2026-03-16 |
| A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab Tezepelumab - Chronic Rhinosinusitis With Nasal Polyps | Phase 3 | Active not recruiting | AstraZeneca | 181 | 2024-12-03 | 2026-10-07 |
| Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal Obstruction Acute Rhinitis, Nasal Obstruction | Recruiting | Laboratoires Gilbert | 114 | 2024-10-22 | 2026-08-25 | |
| Clinical Outcomes and Patient Satisfaction With Velnez Versus Nasopore in Nasal Surgery VELNEZ Nasal Pack, NASOPORE Nasal Pack - Rhinosinusitis, Sinusitis | Not applicable | Completed | Ayu, Inc. | 20 | 2024-09-11 | 2026-05-06 |
| Combination of Oral Supplement With Fatty Acids, Vitamin B6, Perilla, and Liquorice With Nasal Steroids for the Treatment of Allergic Rhinitis Oral fatty acid, Mometasone Furoate Nasal Spray (MFNS) - Allergic Rhinitis | Early Phase 1 | Completed | Isola Tiberina - Gemelli Isola Hospital, Rome, Italy | 400 | 2024-09-01 | 2025-06-12 |
| Dexmedetomidine Infusion in Either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery functional endoscopic sinus surgery, Dexmedetomidine - Rhinosinusitis | Phase 4 | Completed | Menoufia University | 50 | 2024-05-01 | 2025-09-08 |
| Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute Rhinosinusitis Nitric Oxide Releasing Solution, Nasal spray with isotonic saline - Recurrent Acute Rhinosinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 162 | 2024-01-16 | 2026-04-22 |
| the Prevalence of Chronic Rhinosinusitis Associated With Inflammatory Bowel Disease and Association With Biomarkers of Epithelial Barrier Damage Observational study - Intestinal Inflammation, Rhinosinusitis | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 100 | 2024-01-01 | 2023-11-29 | |
| Prevalence of ENT Diseseas Conscripts, Military Induction Board | Unknown | Medical University of Graz | 10000 | 2023-12-01 | 2023-10-27 | |
| Evaluation of Patient Satisfaction During Treatment With Dupilumab in Severe and Recurrent Nasosinusal Polyposis Despite Appropriate Medical and Surgical Treatment. Questionnaires - Chronic Rhinosinusitis With Nasal Polyps | Terminated | IHU Strasbourg | 32 | 2023-08-30 | 2024-01-08 | |
| Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction: "DEVALPO" Measurement of peak nasal flow. - Acute Rhinitis, Nasal Obstruction | Not applicable | Recruiting | Laboratoires Gilbert | 101 | 2023-06-23 | 2026-08-26 |
| Effect of Hot Saline Irrigation on the Operative Field During Endoscopic Sinus Surgery Normal saline heated up to 50 °C - Rhinosinusitis | Not applicable | Completed | Rawalpindi Medical College | 60 | 2023-06-16 | 2024-04-02 |
| Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis. Pulsed electromagnetic field - Magnetic Therapy, Rhinosinusitis | Not applicable | Completed | Cairo University | 37 | 2023-06-15 | 2024-07-23 |
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Sinusitis (16) · Rhinitis, Allergic (9) · Common Cold (7) · Nasal Polyps (7) · Respiratory Tract Infections (7) · Rhinitis (7) · Asthma (4) · Nasal Obstruction (4) · Rhinitis, Allergic, Perennial (4) · Bronchiolitis Obliterans Syndrome (3) · Bronchitis (3) · COVID-19 (3) · Cystic Fibrosis (3) · Disease (3)
Infections (90) · Nose Diseases (90) · Paranasal Sinus Diseases (89) · Respiratory Tract Diseases (89) · Otorhinolaryngologic Diseases (87) · Respiratory Tract Infections (83) · Rhinitis (83) · Sinusitis (74) · Immune System Diseases (19) · Pathological Conditions, Signs and Symptoms (19) · Hypersensitivity (16) · Lung Diseases (16) · Respiratory Hypersensitivity (16) · Hypersensitivity, Immediate (15) · RNA Virus Infections (11)
Sodium Chloride (8) · Budesonide (3) · Acetylcysteine (2) · Guaifenesin (2) · Observation (2) · Pseudoephedrine (2) · Acetaminophen (1) · Amiloride (1) · Amoxicillin (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Dexmedetomidine (1) · Dexpramipexole (1) · Dextromethorphan (1) · Doxycycline (1) · Equipment and Supplies (1)
Cairo University (3) · Entellus Medical, Inc. (3) · Washington University School of Medicine (3) · Bitop AG (2) · Greg Davis (2) · Huro Biotech Joint Stock Company (2) · Laboratoires Gilbert (2) · Pari Pharma GmbH (2) · University of Alabama at Birmingham (2) · University of British Columbia (2) · University of Jena (2) · Adams Respiratory Therapeutics (1) · Al-Azhar University (1) · Asociacion Colaboracion Cochrane Iberoamericana (1) · Assuta Hospital Systems (1)
United States (25) · Canada (9) · France (9) · Germany (9) · Egypt (6) · Spain (4) · Bulgaria (3) · Switzerland (3) · Israel (2) · Italy (2) · Poland (2) · Russia (2) · Saudi Arabia (2) · Thailand (2) · Vietnam (2)
Arif Janjua, MD (2) · Brad Woodworth, MD (2) · Greg E Davis, MD, MPH (2) · Jay F Piccirillo, MD (2) · Jochen Mainz, M.D. (2) · Pablo Alonso Coello, PhD (2) · A Y Ovchinnikov (1) · Aaron Pearlman, MD (1) · Aila Kristo, MD (1) · Andreas Bilstein, Dr. (1) · Andrew M Wilson (1) · Andrew N. Goldberg, MD (1) · Anna Marttila, MD (1)
PMID 10480701, PMID 12049564, PMID 12091997, PMID 15023840, PMID 15316237, PMID 15510034, PMID 17063747, PMID 17405780, PMID 17882910, PMID 21844413, PMID 21994147, PMID 22170775, PMID 22337680, PMID 23378777, PMID 23621514, PMID 23682979, PMID 23785241, PMID 24358625, PMID 24594542, PMID 25590308, PMID 26337346, PMID 26719947, PMID 27267518, PMID 27394715, PMID 27888649, PMID 28390807, PMID 29178954, PMID 29879268, PMID 33866681, PMID 34819186, PMID 35390177, PMID 37784098, PMID 38358423, PMID 38652923, PMID 8281565, PMID 833373, PMID 8922148, PMID 9473061, PMID 9755259
2019 (1), K08HL107142 (1), R37HL068546 (1), U01AI064655 (1)