24 completed, 5 unknown, 2 terminated, 1 recruiting. 11 Phase 1, 9 Not applicable, 6 Phase 4, 4 Phase 2, 4 Phase 3.
Follow Quinine: new trials by email Literature Review of Quinine trials Research Report on Quinine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Intragastric Quinine, Alone or Combined With L-isoleucine, on Postprandial Glycaemic Control Quinine, L-isoleucine, Combination of quinine and L-isoleucine - Healthy | Not applicable | Completed | University of Adelaide | 15 | 2023-06-19 | 2024-12-10 |
| Efficacy of Only IV Artesunate Versus IV Artesunate Plus IV Quinine in the Treatment of Severe Malaria in Children: A Comparative Study IV Artesunate, IV Quinine Hydrochloride - Malaria | Not applicable | Completed | RESnTEC, Institute of Research | 104 | 2023-03-01 | 2024-06-26 |
| Effects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic Control Quinine, L-leucine, Combination of quinine and L-leucine - Healthy | Not applicable | Completed | University of Adelaide | 15 | 2023-02-02 | 2024-12-10 |
| Effectiveness and Safety of Quinine Sulfate as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia ( DEAL-COVID19 ) Standard of Care + Quinine Sulfate, Standard of Care - COVID-19 | Not applicable | Unknown | Universitas Padjadjaran | 100 | 2021-04-26 | 2023-04-11 |
| Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide Release Quinine Hydrochloride, Placebo - Obesity | Phase 1 | Unknown | Universitaire Ziekenhuizen KU Leuven | 40 | 2020-10-29 | 2024-07-03 |
| Topical Irrigation Therapy for CRS Quinine Sulfate, Placebo - Rhinitis, Sinusitis | Phase 1 / Phase 2 | Terminated | University of Pennsylvania | 10 | 2015-10-01 | 2019-03-13 |
| Brain Responses to Intragastric Administration of a Bitter Agonist in Homeostatic and Hedonic Brain Regions Quinine hydrochloride, Control - Healthy | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 15 | 2015-09-01 | 2016-10-27 |
| Taste Physiology in Obese Volunteers Before and After Bariatric Surgery Placebo, Glucose, Monosodium glutamate - Obesity | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 16 | 2014-12-01 | 2025-04-03 |
| Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain acetazolamide, Quinine, Riboflavin - Compliance, Chronic Pain | Phase 2 | Withdrawn | Georgetown University | 2014-12-01 | 2017-02-10 | |
| Parenteral Artesunate Compared to Quinine as a Cause of Late Anaemia in African Children With Malaria artesunate, quinine - Anaemia | Phase 4 | Completed | University of Oxford | 217 | 2014-06-01 | 2015-06-01 |
| A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon Artesunate, Quinine - Malaria | Phase 3 | Completed | University of Yaounde 1 | 238 | 2013-09-01 | 2015-10-01 |
| Taste Physiology in Healthy, Normal-weight Volunteers Single intragastric instillation of 200 mL tap water via nasogastric tube, Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube, Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube - Exploratory Behavior | Not applicable | Completed | University Hospital, Basel, Switzerland | 12 | 2013-03-01 | 2014-10-03 |
| Intravenous Artesunate and Malaria artesunate, Quinine - Malaria | Phase 4 | Unknown | University of Khartoum | 80 | 2013-03-01 | 2013-03-06 |
| Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa Arthemeter-lumefantrine, Artesunate mefloquine, Dihydroartemisinin piperaquine - Drug Resistant Malaria Due to Plasmodium Falciparum | Phase 3 | Completed | University of Bamenda | 300 | 2013-01-01 | 2016-11-29 |
| Interactions Between Intravenous Cocaine and Acetazolamide or Quinine cocaine, quinine, acetazolamide - Cocaine Use, Pharmacokinetics | Phase 1 | Completed | National Institute on Drug Abuse (NIDA) | 14 | 2012-10-24 | 2018-07-05 |
| Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria Artemether/Lumefantrine, Artesunate/Amodiaquine, Quinine + Clindamycin - Malaria | Phase 3 | Completed | Universiteit Antwerpen | 2117 | 2012-05-01 | 2014-10-22 |
| The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake Denatonium benzoate, Quinine hydrochloride, Tap water - Healthy, Obesity | Not applicable | Unknown | Universitaire Ziekenhuizen KU Leuven | 98 | 2011-08-01 | 2016-05-03 |
| Superiority of ArTiMist Versus Quinine in Children With Severe Malaria Artemether Sublingual Spray, Quinine - Plasmodium Falciparum Malaria | Phase 3 | Completed | Proto Pharma Ltd | 151 | 2010-12-01 | 2014-02-28 |
| Efficacy of ArTiMist™ in Children Quinine, Artemether - Falciparum Malaria | Phase 2 | Completed | Proto Pharma Ltd | 31 | 2009-12-01 | 2011-01-27 |
| Drug-Drug Interaction Study Between Quinine Sulfate and Rosiglitazone Rosiglitazone 4 mg Tablets, Quinine Sulfate 324 mg Capsules - Healthy | Phase 1 | Completed | Mutual Pharmaceutical Company, Inc. | 23 | 2008-09-01 | 2012-08-07 |
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Malaria (11) · Malaria, Falciparum (3) · Obesity (3) · Parasitic Diseases (2) · Protozoan Infections (2) · AIDS-Related Complex (1) · Acquired Immunodeficiency Syndrome (1) · Anemia (1) · COVID-19 (1) · Chronic Pain (1) · Exploratory Behavior (1) · HIV Infections (1) · Lymphoma, Follicular (1) · Narcotic-Related Disorders (1) · Opioid-Related Disorders (1)
Mutual Pharmaceutical Company, Inc. (8) · Universitaire Ziekenhuizen KU Leuven (3) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Proto Pharma Ltd (2) · University Hospital, Basel, Switzerland (2) · University of Adelaide (2) · Albert Schweitzer Hospital (1) · Epicentre (1) · Georgetown University (1) · Jimma University (1) · Makerere University (1) · National Institute on Drug Abuse (NIDA) (1) · RESnTEC, Institute of Research (1) · Universitas Padjadjaran (1) · Universiteit Antwerpen (1)
United States (9) · Uganda (3) · Australia (2) · Switzerland (2) · Belgium (1) · Burkina Faso (1) · Cameroon (1) · Canada (1) · Democratic Republic of the Congo (1) · Ethiopia (1) · Gabon (1) · Ghana (1) · Indonesia (1) · Pakistan (1) · Republic of the Congo (1)
Matthew Davis, MD (4) · Christine Feinle-Bisset, PhD (2) · Jan Tack, Prof (2) · Ambrose O Talisuna, PhD (1) · Anthony R Godfrey, PharmD (1) · Barrie March, MD (1) · Carolyn Nabasumba, M.B.Ch.B (1) · Christoph Beglinger, MD (1) · Christoph Beglinger, Prof (1) · Daryl Bendel, MBChB MBA Dip Pharm Med MFPM (1) · Daryl Bendel, MBChB MFPM (1) · Dennis Swearingen, MD (1) · Elizabeth Ashley, MB BS (1)
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