82 completed, 28 unknown, 16 recruiting, 11 terminated. 39 Not applicable, 34 Phase 3, 27 Phase 2, 19 Phase 4, 7 Phase 1.
Follow Nasal Polyps: new trials by email Literature Review of Nasal Polyps trials Research Report on Nasal Polyps
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| China CRSwNP Registry Study Routine Clinical Care for CRSwNP - Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) | Not yet recruiting | Beijing Tongren Hospital | 1000 | 2026-10-31 | 2026-08-31 | |
| FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery - Chronic Sinusitis, Nasal Polyposis | Not applicable | Not yet recruiting | Services Institute of Medical Sciences, Pakistan | 174 | 2026-10-15 | 2026-10-23 |
| A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) GSK5784283, Placebo, Standard of Care - Nasal Polyps | Phase 3 | Recruiting | GlaxoSmithKline | 218 | 2026-09-28 | 2026-10-14 |
| A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) GSK5784283, Placebo, Standard of Care - Nasal Polyps | Phase 3 | Recruiting | GlaxoSmithKline | 218 | 2026-09-03 | 2026-10-09 |
| Active vs. Passive VR During Office-based ENT Procedures Passive virtual reality headset or goggles, Active virtual reality headset or goggles - Pain, Anxiety | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 132 | 2026-09-01 | 2026-08-17 |
| Phenotyping of Type 2 Inflammation Profile by Rheology of Nasal Secretions and Tissue Quantification of Eosinophilic Polymorphonuclear Cells in the Middle Turbinate Sinonasal sample collection and inflammatory assessment - Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) | Not applicable | Not yet recruiting | University Hospital, Montpellier | 60 | 2026-08-01 | 2026-04-13 |
| Efficacy and Safety of Depemokimab Monotherapy Without Concomitant Use of Intranasal Corticosteroids (INCS) in Japanese Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Depemokimab - Nasal Polyps | Phase 4 | Recruiting | GlaxoSmithKline | 28 | 2026-07-15 | 2026-09-08 |
| Inflammatory Profiles, Histopathological Features, and Remodeling Factors in Chronic Rhinosinusitis With Nasal Polyps Budesonide - CRSwNP, Chronic Rhinosinusitis (Diagnosis), Nasal Polyposis | Not applicable | Not yet recruiting | St. Paul's Sinus Centre | 10 | 2026-07-01 | 2026-04-14 |
| Biologics in Chronic Rhinosinusitis With Nasal Polyposis Biologic Agents - Chronic Sinusitis, Nasal Polyps | Phase 4 | Recruiting | Medical University of South Carolina | 504 | 2026-06-03 | 2026-09-28 |
| Preoperative Stapokibart for Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps Stapokibart, Matched placebo - Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) | Not applicable | Not yet recruiting | Beijing Tongren Hospital | 48 | 2026-06-01 | 2026-06-01 |
| Triamcinolone Nanocapsules After Endoscopic Nasal Surgery Triamcinolone Acetonide-Loaded Polymeric Nanocapsules, Normal Saline Nasal Irrigation - Chronic Rhinosinusitis (CRS), Nasal Polyps | Phase 2 | Recruiting | Deraya University | 50 | 2026-05-01 | 2026-07-27 |
| Metabolic and Immunologic Biomarkers in Chronic Rhinosinusitis With Nasal Polyps Nasal polyp tissue and blood sampling, Nasal mucosa and blood sampling - Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Nasal Polyps | Recruiting | Harran University | 80 | 2026-03-15 | 2026-10-19 | |
| Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training Smell Training - Smell Loss, Chronic Rhinosinusitis (CRS) | Not applicable | Recruiting | The Cleveland Clinic | 52 | 2025-12-09 | 2026-07-02 |
| The German National CRS Registry (GenreCRS): Clinical Evaluation of the New European Academy for Allergy and Clinical Immunology (EAACI) Criteria for CRSwNP Disease Control, Remission and Cure in a Real-World Evidence Study Approach Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps | Not yet recruiting | Ärzteverband Deutscher Allergologen e.V. | 500 | 2025-10-01 | 2025-06-04 | |
| Long-term Effect of Dupilumab in N-ERD Observational follow-up of standard Dupilumab treatment - NSAID-Induced Asthma, NSAIDs Hypersensitivity | Completed | Medical University of Vienna | 15 | 2025-09-01 | 2026-10-07 | |
| Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps Nasopharyngeal Lymphoid Tissue Ablation, Full-House Endoscopic Sinus Surgery - Nasal Polyps | Not applicable | Recruiting | Tongji Hospital | 32 | 2025-07-01 | 2025-11-24 |
| Complete Remission After Treatment With Biologics for Nasal Polyps DUPIXENT®, NUCALA®, Dupi discontinuation - Nasal Polyps | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 66 | 2025-04-03 | 2025-12-05 |
| Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry Antiasthmatic - Chronic Asthma | Recruiting | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 1200 | 2025-02-01 | 2026-03-30 | |
| A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps 611, Placebo - Sinusitis, Nasal Polyps | Phase 3 | Active not recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 243 | 2024-11-22 | 2025-12-03 |
| Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray Dupilumab - Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS) | Phase 3 | Withdrawn | National Institute on Deafness and Other Communication Disorders (NIDCD) | 2024-07-17 | 2024-07-25 |
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Sinusitis (23) · Asthma (20) · Disease (11) · Rhinosinusitis (7) · Nose Diseases (5) · Rhinitis, Allergic (5) · Asthma, Aspirin-Induced (4) · Paranasal Sinus Diseases (4) · Rhinitis (4) · Respiratory Tract Diseases (3) · Allergic Fungal Sinusitis (2) · Bronchiolitis Obliterans Syndrome (2) · Chronic Disease (2) · Eosinophilia (2)
Pathological Conditions, Anatomical (157) · Pathological Conditions, Signs and Symptoms (157) · Otorhinolaryngologic Diseases (155) · Polyps (155) · Respiratory Tract Diseases (154) · Nose Diseases (152) · Infections (34) · Respiratory Tract Infections (33) · Immune System Diseases (31) · Hypersensitivity (29) · Hypersensitivity, Immediate (29) · Paranasal Sinus Diseases (28) · Respiratory Hypersensitivity (27) · Bronchial Diseases (23) · Lung Diseases (23)
Mometasone Furoate (14) · dupilumab (10) · mepolizumab (10) · Omalizumab (8) · Budesonide (6) · Fluticasone (5) · benralizumab (5) · Prednisone (4) · Blood Specimen Collection (3) · Prednisolone (3) · Standard of Care (3) · Adrenal Cortex Hormones (2) · Ambulatory Care Facilities (2) · Biological Products (2) · Doxycycline (2)
GlaxoSmithKline (9) · Beijing Tongren Hospital (5) · Brigham and Women's Hospital (5) · AstraZeneca (4) · Ain Shams University (3) · Assiut University (3) · Hoffmann-La Roche (3) · Intersect ENT (3) · Johns Hopkins University (3) · Northwestern University (3) · Organon and Co (3) · University Hospital Ostrava (3) · University Hospital, Ghent (3) · University Hospital, Lille (3) · Benjamin Bleier (2)
United States (60) · China (18) · Canada (17) · France (17) · Belgium (13) · Spain (13) · Germany (11) · Poland (10) · Czechia (9) · Egypt (8) · Italy (8) · United Kingdom (8) · Japan (7) · Hungary (6) · Netherlands (6)
Tanya M Laidlaw, MD (3) · Benjamin S Bleier, MD (2) · Claus Bachert, MD, PhD (2) · Geoffrey Mortuaire, MD (2) · Joseph K Han, MD (2) · Lorena Soto-Retes, physician (2) · Louis-Philippe Boulet, MD (2) · Luo Zhang, MD (2) · Ahmed Gamal Sholkamy, Doctor (1) · Alan H. Shikani, MD (1) · Aly Ragaie (1) · Andrew Murr, MD (1)
PMID 33710614, PMID 33548517, PMID 37951571, PMID 38197558, PMID 15817806, PMID 22469599, PMID 34110505, PMID 34382434, PMID 34437720, PMID 37214171, PMID 40037388, PMID 41461999, PMID 10480701, PMID 10719291, PMID 11240947, PMID 12049564, PMID 12091997, PMID 12789212, PMID 12903683, PMID 14616096, PMID 15117622, PMID 15379582, PMID 15647046, PMID 16218509, PMID 17075402, PMID 18331513, PMID 19289710, PMID 19713445, PMID 20638762, PMID 20738346, PMID 21271600, PMID 21357906, PMID 21676042, PMID 21714471, PMID 21739093, PMID 23193904, PMID 23255493, PMID 23331528, PMID 23818462, PMID 24337046, PMID 24589344, PMID 24817242, PMID 25137523, PMID 26046448, PMID 26452438, PMID 26575524, PMID 26679480, PMID 26836729, PMID 26992115, PMID 27924776
2017 (4), 2015 (2), 2023 (2), 2008 (1), 2016 (1), 2018 (1), 2019 (1), R37HL068546 (1), U19AI095219 (1)