17 completed, 7 unknown, 4 terminated, 2 active not recruiting. 34 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 34 | Completed 17, Unknown 7, Terminated 4, Active not recruiting 2, Recruiting 2, Withdrawn 2 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
Follow Sinusitis: new trials by email Literature Review of Sinusitis trials Research Report on Sinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult Patients Raphamin, Placebo - Rhinosinusitis, Rhinosinusitis Acute | Phase 3 | Recruiting | Materia Medica Holding | 552 | 2025-04-03 | 2026-03-16 |
| A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab Tezepelumab - Chronic Rhinosinusitis With Nasal Polyps | Phase 3 | Active not recruiting | AstraZeneca | 181 | 2024-12-03 | 2026-10-07 |
| A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps 611, Placebo - Sinusitis, Nasal Polyps | Phase 3 | Active not recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 243 | 2024-11-22 | 2025-12-03 |
| Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray Dupilumab - Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS) | Phase 3 | Withdrawn | National Institute on Deafness and Other Communication Disorders (NIDCD) | 2024-07-17 | 2024-07-25 | |
| Add-on Dupilumab for AFRS as Postoperative Therapy (ADAPT) Dupilumab, Placebo, Intranasal Corticosteroid Sprays (INCS) - Allergic Fungal Rhinosinusitis | Phase 3 | Terminated | Emory University | 5 | 2023-10-26 | 2025-05-08 |
| Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults Azithromycin Oral Tablet, Placebo - Sinusitis, Chronic, Sinus Infection Chronic | Phase 3 | Recruiting | Centre Hospitalier Intercommunal Creteil | 230 | 2022-11-21 | 2025-08-29 |
| Establishment of Precise Diagnosis and Treatment System for Refractory Chronic Rhinosinusitis Mometasone furoate nasal spray hormone, Mometasone furoate nasal spray hormone + oral hormone, Mometasone furoate nasal spray hormone + omalizumab - Sinusitis | Phase 3 | Unknown | Beijing Tongren Hospital | 87 | 2022-05-25 | 2022-05-25 |
| Dupilumab in Allergic Fungal Rhinosinusitis (AFRS) Dupilumab SAR231893, Placebo - Allergic Fungal Rhinosinusitis | Phase 3 | Completed | Sanofi | 62 | 2020-12-01 | 2026-09-03 |
| Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis acetylcysteine, Placebo - Rhinosinusitis | Phase 3 | Completed | Sandoz | 944 | 2020-10-22 | 2021-11-19 |
| Investigating the Effect of Herbal Medicine Nasal Irrigation on Treatment of Chronic Rhinitis and Sinusitis Taiwan Scientific" noninvasive blood pressure meter TS-0411, Meridian Energy Analysis Device(MEAD), bacteria culture - Nasal Disease | Phase 2 / Phase 3 | Unknown | Chang Gung Memorial Hospital | 250 | 2019-12-31 | 2020-06-22 |
| Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis. Infex 400 MR, Infex 200 IR - Sinusitis, Sinusitis, Acute | Phase 3 | Unknown | Neutec Ar-Ge San ve Tic A.Ş | 100 | 2019-05-15 | 2023-01-05 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients Tobramycin nebulized nasally, Physiologic serum nebulized nasally - Cystic Fibrosis, Rhinosinusitis | Phase 3 | Terminated | Virginie ESCABASSE | 86 | 2017-02-16 | 2023-02-15 |
| Effect of Reslizumab in Chronic Rhinosinusitis Reslizumab, Placebo - Sinusitis | Phase 3 | Unknown | Joshua S. Jacobs | 30 | 2016-06-01 | 2018-02-01 |
| Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit? Amoxicillin-clavulanate, Placebo - Sinusitis, Respiratory Tract Infections | Phase 3 | Completed | Nader Shaikh | 515 | 2016-02-01 | 2023-06-29 |
| Rates of Middle Meatus Synechiae Formation Post Endoscopic Sinus Surgery Restora™ Steroid eluting spacer, Silastic Silicone Spacer - Sinusitis | Phase 3 | Terminated | Cedars-Sinai Medical Center | 3 | 2015-12-01 | 2017-11-17 |
| Prednisone in Chronic Rhinosinusitis Without Nasal Polyps Prednisone, Placebo - Sinusitis, Chronic Rhinosinusitis | Phase 3 | Unknown | University of Chile | 90 | 2015-06-01 | 2015-06-04 |
| Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis Amoxicillin-Potassium Clavulanate Combination - Sinusitis, Acute | Phase 3 | Completed | GlaxoSmithKline | 27 | 2013-08-30 | 2017-07-11 |
| Pulmozyme in Cystic Fibrosis With Sinusitis Pulmozyme single use ampule, placebo - Sinusitis, Cystic Fibrosis | Phase 3 | Withdrawn | Milton S. Hershey Medical Center | 2013-07-01 | 2017-07-21 | |
| Evaluation of Inhaled Treatment in Sinusitis methylprednisolone, Budesonide - Sinusitis | Phase 2 / Phase 3 | Completed | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 50 | 2013-07-01 | 2014-01-27 |
Showing 20 of 34. Sign in to see all of them.
Rhinosinusitis (8) · Maxillary Sinusitis (4) · Respiratory Tract Infections (4) · Rhinitis (4) · Allergic Fungal Sinusitis (3) · Cystic Fibrosis (3) · Infections (3) · Nasal Polyps (3) · Bronchiolitis Obliterans Syndrome (2) · Nose Diseases (2) · Asthma (1) · Bronchiolitis (1) · Constipation (1) · Croup (1)
Otorhinolaryngologic Diseases (34) · Paranasal Sinus Diseases (33) · Respiratory Tract Diseases (33) · Nose Diseases (32) · Infections (31) · Respiratory Tract Infections (30) · Rhinitis (8) · Immune System Diseases (6) · Lung Diseases (6) · Bronchial Diseases (4) · Hypersensitivity (4) · Hypersensitivity, Immediate (4) · Lung Diseases, Obstructive (4) · Pathological Conditions, Signs and Symptoms (4)
Levofloxacin (4) · Sodium Chloride (3) · dupilumab (3) · Amoxicillin-Potassium Clavulanate Combination (2) · Anti-Bacterial Agents (2) · Azithromycin (2) · dornase alfa (2) · telithromycin (2) · Acetylcysteine (1) · Amoxicillin (1) · Budesonide (1) · Hormones (1) · Methylprednisolone (1) · Moxifloxacin (1) · Omalizumab (1)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3) · Sanofi (3) · AstraZeneca (1) · Bayer (1) · Beijing Tongren Hospital (1) · Cedars-Sinai Medical Center (1) · Centre Hospitalier Intercommunal Creteil (1) · Chang Gung Memorial Hospital (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Emory University (1) · GlaxoSmithKline (1) · Integra LifeSciences Corporation (1) · Joshua S. Jacobs (1) · Materia Medica Holding (1) · Milton S. Hershey Medical Center (1)
United States (12) · Germany (4) · China (3) · France (3) · Japan (3) · Russia (3) · Argentina (2) · Bulgaria (2) · Canada (2) · Chile (2) · India (2) · Poland (2) · Turkey (Türkiye) (2) · Brazil (1) · Costa Rica (1)
Babak Saedi, professor (1) · Christopher Church, MD (1) · Constanza J Valdes, MD (1) · Coralie Colbrant, PT (1) · Ellen R Wald, MD (1) · Enrico Heffler, MD, PhD (1) · Gregory Reychler, PhD (1) · Jochen Mainz, M.D. (1) · Joshua Jacobs, MD (1) · Joshua Levy, M.D. (1)
PMID 15023840, PMID 15316237, PMID 15510034, PMID 17178300, PMID 17405780, PMID 17882910, PMID 20422704, PMID 20500134, PMID 21994147, PMID 22287332, PMID 22764607, PMID 22887970, PMID 23378777, PMID 23785241, PMID 24594542, PMID 24610673, PMID 24753507, PMID 24889751, PMID 27394715, PMID 28390807, PMID 35390177, PMID 37490085, PMID 42498125, PMID 8281565, PMID 9755259
2019 (1), U01AI118506 (1)