Paranasal Sinus Diseases: Clinical Trials

181 completed, 50 unknown, 27 terminated, 26 recruiting. 115 Not applicable, 43 Phase 2, 40 Phase 4, 38 Phase 3, 17 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	115	Completed 63, Unknown 18, Terminated 10, Withdrawn 9, Recruiting 7, Not yet recruiting 4, Active not recruiting 3, Enrolling by invitation 1
Phase 2	43	Completed 27, Terminated 5, Active not recruiting 3, Recruiting 3, Unknown 3, Withdrawn 2
Phase 4	40	Completed 26, Terminated 5, Unknown 4, Recruiting 3, Active not recruiting 1, Withdrawn 1
Phase 3	38	Completed 18, Unknown 7, Recruiting 5, Terminated 4, Active not recruiting 2, Withdrawn 2
Phase 1	17	Completed 13, Terminated 2, Recruiting 1, Withdrawn 1
Early Phase 1	7	Unknown 3, Completed 2, Terminated 1, Withdrawn 1

Follow Paranasal Sinus Diseases: new trials by email Literature Review of Paranasal Sinus Diseases trials Research Report on Paranasal Sinus Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma	Phase 1 / Phase 2	Recruiting	National Cancer Institute (NCI)	120	2026-11-03	2026-10-29
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers Quinton Medical Nasal Health Baby® - Nasal Congestion, Common Cold		Not yet recruiting	Laboratoires Quinton International S.L.	83	2026-11-01	2026-10-13
Observational Study of RHINOSEDAL in Acute Nasal Obstruction RHINOSEDAL - Nasal Obstruction, Common Cold		Not yet recruiting	Laboratoires Elerte	126	2026-10-15	2026-06-02
Peppermint and Decongestant Technique on Chronic Sinusitis Sinus self-massage and inhalation of steated boiled peppermint - Sinus Disease	Not applicable	Not yet recruiting	Assiut University	108	2026-10-01	2026-10-08
Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI) Respiratory Tract Infection, Smell Disorder		Recruiting	National Institute on Deafness and Other Communication Disorders (NIDCD)	80	2026-10-01	2026-10-09
Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis) Amoxicillin, Amoxi Clavulanate, Amoxicillin Placebo - ACUTE SINUSITIS, Sinusitis	Phase 4	Recruiting	Nader Shaikh	1100	2026-10-01	2026-10-20
A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) GSK5784283, Placebo, Standard of Care - Nasal Polyps	Phase 3	Recruiting	GlaxoSmithKline	218	2026-09-28	2026-10-14
A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) GSK5784283, Placebo, Standard of Care - Nasal Polyps	Phase 3	Recruiting	GlaxoSmithKline	218	2026-09-03	2026-10-09
Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis: Bee Venom Phonophoresis, Standard Care (oral decongestants + saline nasal irrigation) - Chronic Sinusitis, Acute Sinusitis	Not applicable	Not yet recruiting	Sinai University	30	2026-08-15	2026-08-04
Biologics in Chronic Rhinosinusitis With Nasal Polyposis Biologic Agents - Chronic Sinusitis, Nasal Polyps	Phase 4	Recruiting	Medical University of South Carolina	504	2026-06-03	2026-09-28
A Phase 1 Study of Cizutamig in IgE Mediated Diseases Cizutamig - IgE-Mediated Hypersensitivity, IgE Mediated Food Allergy	Phase 1	Withdrawn	Candid Therapeutics		2026-04-01	2026-07-22
Evaluation of Endoscopic Management of Sinonasal Tumors In Difficult Anatomical Locations endoscopic approch - Nasal Cavity and Paranasal Sinus Cancer	Not applicable	Not yet recruiting	Assiut University	25	2026-04-01	2026-04-06
RhinAV_Evaluation of Treatments for Acute Viral Rhinitis, Rhinosinusitis, and Rhinopharyngitis PIR, NS, NHE - Rhinitis Acute, Rhinitis Viral	Not applicable	Recruiting	University Hospital, Clermont-Ferrand	150	2026-02-25	2026-06-15
Herbal Tea Extract for Management of Rhinosinusitis mango leaves extract, local steroids, nasal saline - Rhino Sinusitis	Not applicable	Completed	Deraya University	30	2025-11-20	2026-04-16
Deviated Nasal Septum Effect on Maxillary Sinus Volumes and Development of Maxillary Sinusitis by CT Deviated Nasal Septum and Maxillary Sinusitis		Not yet recruiting	Assiut University	120	2025-10-01	2025-10-07
Effectiveness on Sino-Nasal Symptoms Of Mepolizumab 300 Mepolizumab 300 mg - Sinus Disease, EGPA - Eosinophilic Granulomatosis With Polyangiitis		Completed	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	52	2025-09-12	2026-05-18
Endoscopic Assessment of Schneiderian Membrane Perforation During Osseodensification-mediated Transcrestal Sinus Floor Elevation With Graftless Immediate Implant Placement in Subsinus Bone Height of 4-6 mm: A Pilot Study. Scheiderian Membrane Perforation - Sinusitis, Periodontal Disease	Not applicable	Completed	Saint-Joseph University	6	2025-09-01	2026-05-01
Radiological and Surgical Analysis of Frontal Recess Variations in Endoscopic Sinus Surgery endosocpic sinus surgery - Frontal Sinusitis, Endoscopic Sinus Surgery	Not applicable	Completed	Al-Azhar University	40	2025-09-01	2026-08-06
Toripalimab With Chemotherapy for Sinus Cancer Toripalimab, Carboplatin, Docetaxel - Sinonasal Cancer, Paranasal Sinus Neoplasms	Phase 2	Recruiting	Dana-Farber Cancer Institute	20	2025-06-17	2026-08-31
The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult Patients Raphamin, Placebo - Rhinosinusitis, Rhinosinusitis Acute	Phase 3	Recruiting	Materia Medica Holding	552	2025-04-03	2026-03-16

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Narrower conditions

Sinusitis (189)  ·  Rhinosinusitis (90)  ·  Nasal Polyps (32)  ·  Paranasal Sinus Neoplasms (24)  ·  Respiratory Tract Infections (20)  ·  Rhinitis (19)  ·  Bronchiolitis Obliterans Syndrome (17)  ·  Maxillary Sinusitis (15)  ·  Rhinitis, Allergic (14)  ·  Asthma (13)  ·  Laryngeal Neoplasms (13)  ·  Mouth Neoplasms (10)  ·  Disease (9)  ·  Bronchitis (8)

Broader conditions

Nose Diseases (318)  ·  Otorhinolaryngologic Diseases (317)  ·  Respiratory Tract Diseases (317)  ·  Infections (281)  ·  Respiratory Tract Infections (264)  ·  Sinusitis (94)  ·  Rhinitis (89)  ·  Pathological Conditions, Signs and Symptoms (73)  ·  Immune System Diseases (54)  ·  Lung Diseases (48)  ·  Lung Diseases, Obstructive (38)  ·  Bronchial Diseases (36)  ·  Hypersensitivity (34)  ·  Respiratory Hypersensitivity (34)

Interventions

Amoxicillin-Potassium Clavulanate Combination (13)  ·  Sodium Chloride (11)  ·  Budesonide (9)  ·  Amoxicillin (7)  ·  Azithromycin (7)  ·  Cisplatin (6)  ·  dupilumab (6)  ·  Levofloxacin (5)  ·  Pseudoephedrine (5)  ·  Radiotherapy (5)  ·  Mometasone Furoate (4)  ·  Moxifloxacin (4)  ·  Nasal Lavage (4)  ·  Prednisone (4)  ·  Saline Solution (4)

Sponsors

St. Paul's Hospital, Canada (8)  ·  Assiut University (7)  ·  GlaxoSmithKline (7)  ·  Entellus Medical, Inc. (6)  ·  Integra LifeSciences Corporation (6)  ·  Sanofi (5)  ·  Bayer (4)  ·  Cairo University (4)  ·  Greg Davis (4)  ·  Pfizer (4)  ·  University of Jena (4)  ·  Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3)  ·  Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3)  ·  Oregon Health and Science University (3)  ·  University of Alabama at Birmingham (3)

Countries

United States (142)  ·  Canada (31)  ·  Germany (19)  ·  France (16)  ·  China (13)  ·  Egypt (11)  ·  Spain (9)  ·  Italy (8)  ·  Poland (8)  ·  Israel (7)  ·  Saudi Arabia (7)  ·  Czechia (6)  ·  Finland (6)  ·  Russia (6)  ·  Argentina (4)

Top investigators

Amin Javer, MD (5)  ·  Amin R Javer, MD, FRCSC, FARS (4)  ·  Ellen R Wald, MD (4)  ·  Greg E Davis, MD, MPH (4)  ·  Peter Catalano, MD (3)  ·  Arif Janjua, MD (2)  ·  Benjamin S Bleier, MD (2)  ·  Brad Woodworth, MD (2)  ·  Domen Vozel, MD, PhD (2)  ·  Jay F Piccirillo, MD (2)  ·  Jeff Grebner (2)

Results publications

PMID 25137523, PMID 10480701, PMID 12049564, PMID 12091997, PMID 15023840, PMID 15125017, PMID 15316237, PMID 15510034, PMID 17063747, PMID 17178300, PMID 17405780, PMID 17424883, PMID 17882910, PMID 18559163, PMID 19344620, PMID 19419611, PMID 19559969, PMID 19564277, PMID 19794023, PMID 20422704, PMID 20428282, PMID 20500134, PMID 20513050, PMID 20830768, PMID 21038023, PMID 21050634, PMID 21246519, PMID 21271600, PMID 21453656, PMID 21844413, PMID 21994147, PMID 22170775, PMID 22287332, PMID 22287426, PMID 22337680, PMID 22736422, PMID 22764607, PMID 22887970, PMID 23136057, PMID 23255493, PMID 23378777, PMID 23424023, PMID 23621514, PMID 23626752, PMID 23656352, PMID 23682979, PMID 23710844, PMID 23785241, PMID 24358625, PMID 24563860

NIH funding

2005 (1), 2019 (1), 2023 (1), K08HL107142 (1), M01RR000069 (1), P30CA042014 (1), R01AI097172 (1), R01HL116213 (1), R37HL068546 (1), U01AI064655 (1), U01AI118506 (1), U10CA180888 (1)