1042 completed, 161 unknown, 122 recruiting, 119 terminated. 431 Not applicable, 252 Phase 2, 187 Phase 1, 169 Phase 3, 88 Phase 4.
Follow Cystic Fibrosis: new trials by email Literature Review of Cystic Fibrosis trials Research Report on Cystic Fibrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetics of CFTR Modulators in Pregnant Individuals and in Postpartum Breastfeeding Mothers Cystic Fibrosis, Pregnancy | Not yet recruiting | University of Minnesota | 30 | 2027-01-01 | 2026-01-20 | |
| Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes | Recruiting | Bettina Mittendorfer | 100 | 2027-01-01 | 2026-05-07 | |
| Type 2 Inflammation in Adults With Cystic Fibrosis Cystic Fibrosis (CF), Type 2 Inflammatory Disorders | Not yet recruiting | University of Virginia | 100 | 2026-11-01 | 2026-10-23 | |
| Reproducibility of Continuous Glucose Monitoring (CGM) in the Assessment of Glucose Metabolism Disorders in Children With Cystic Fibrosis Continuous Glucose Monitoring, Eating Habits Questionnaire, Use of an actigraphy watch - Glucose Metabolism Disorders in Cystic Fibrosis | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 30 | 2026-11-01 | 2026-10-01 |
| Management of Breast Fibroadenoma: Comparing Observation, Microwave Ablation, and Surgical Excision Ultrasound-guided percutaneous microwave ablation, Conventional open surgical excision - Fibroadenoma, Breast Fibroadenoma | Not applicable | Not yet recruiting | Sohag University | 60 | 2026-11-01 | 2026-10-22 |
| Novel Point-of-care Sweat Chloride Testing Device for Monitoring CFTR Function micro Sweat Test Patch (mSTP), Sweat Testing using SOC - Cystic Fibrosis | Not applicable | Not yet recruiting | Emory University | 300 | 2026-11-01 | 2026-10-27 |
| Iron Repletion in Cystic Fibrosis IV Repletion, PO Repletion - Cystic Fibrosis, Iron Deficiencies | Phase 4 | Not yet recruiting | University of Michigan | 100 | 2026-11-01 | 2026-10-29 |
| Nutrition Supplement for Cystic Fibrosis Common form supplementation, Uncommon nutrient supplementation - Cystic Fibrosis (CF) | Not applicable | Not yet recruiting | Ohio State University | 60 | 2026-10-15 | 2026-09-21 |
| Vascular Health and Function in Cystic Fibrosis Non-invasive vascular, cerebrovascular and autonomic assessment - Cystic Fibrosis, Endothelial Dysfunction | Not yet recruiting | Liverpool Heart and Chest Hospital NHS Foundation Trust | 100 | 2026-10-10 | 2026-10-29 | |
| SPutum Induction and Nebuliser deviCEs for Patients With CF Sputum induction - Cystic Fibrosis (CF), Cystic Fibrosis Lung Disease | Not applicable | Not yet recruiting | Royal Brompton & Harefield NHS Foundation Trust | 30 | 2026-10-01 | 2026-10-19 |
| A Study to Evaluate Safety and Explore Efficacy of New Lipase NHS7108 in Adult Participants With Exocrine Pancreatic Insufficiency. NHS7108, Zenpep® - Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF) | Phase 2 | Recruiting | Aimmune Nestlé Health Science US R&D, LLC | 66 | 2026-10-01 | 2026-10-01 |
| A Phase 1 Relative Bioavailability Study of a VX-581 Tablet Formulation VX-581 - Cystic Fibrosis | Phase 1 | Active not recruiting | Vertex Pharmaceuticals Incorporated | 16 | 2026-09-23 | 2026-10-27 |
| Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Elexacaftor, Tezacaftor, Ivacaftor, Ivacaftor (VX-770) - Cystic Fibrosis (CF) | Phase 4 | Recruiting | Istituto Giannina Gaslini | 50 | 2026-09-18 | 2026-10-14 |
| Rethinking Early Airway Clearence Therapies As-needed hypertonic saline (HS), Twice daily hypertonic saline (HS), As-needed dornase alfa (DA) - Cystic Fibrosis (CF) | Not applicable | Not yet recruiting | Nicole Hamblett | 405 | 2026-09-15 | 2026-07-10 |
| Heart and Blood Vessels Health in People With Cystic Fibrosis Cystic Fibrosis (CF), Cardiovascular (CV) Risk | Not yet recruiting | Liverpool Heart and Chest Hospital NHS Foundation Trust | 32 | 2026-09-01 | 2026-08-14 | |
| Gastrointestinal Response of Pediatric Cystic Fibrosis Patients on Mediterranean Diet Mediterranean diet - Cystic Fibrosis (CF), Cystic Fibrosis Gastrointestinal Disease | Not applicable | Recruiting | Dartmouth-Hitchcock Medical Center | 20 | 2026-09-01 | 2026-07-02 |
| MRI Parameters as Biomarkers in Cystic Fibrosis (FEMPTO) Linaclotide 290 micrograms, Placebo - Cystic Fibrosis (CF) | Not applicable | Not yet recruiting | University of Nottingham | 12 | 2026-09-01 | 2026-08-21 |
| Home Air Pollution in Children With Cystic Fibrosis Study Cystic Fibrosis (CF) | Not yet recruiting | Seattle Children's Hospital | 200 | 2026-09-01 | 2026-06-24 | |
| Bacteriophages for Adults With Cystic Fibrosis and Chronic Achromobacter Lung Infection AchromoPhage - Cystic Fibrosis (CF), Achromobacter Infection | Phase 1 | Recruiting | Ghady Haidar | 12 | 2026-08-20 | 2026-10-08 |
| Verapamil Effect in Cystic Fibrosis-related Dysglycemia Verapamil Hydrochloride - Cystic Fibrosis Related Diabetes, Cystic Fibrosis (CF) | Phase 2 | Not yet recruiting | Rhode Island Hospital | 30 | 2026-08-01 | 2026-07-09 |
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Lung Diseases (57) · Pseudomonas Infections (56) · Exocrine Pancreatic Insufficiency (54) · Pulmonary Disease, Chronic Obstructive (49) · Asthma (47) · Motor Activity (41) · Respiratory Tract Diseases (39) · Diabetes Mellitus (38) · Bronchiectasis (36) · Genetic Diseases, Inborn (33) · Inflammation (24) · Rare Diseases (21) · Ciliary Motility Disorders (18) · Pancreatic Diseases (18)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1582) · Infant, Newborn, Diseases (1577) · Digestive System Diseases (1569) · Pancreatic Diseases (1565) · Genetic Diseases, Inborn (1550) · Respiratory Tract Diseases (1544) · Lung Diseases (1526) · Pathological Conditions, Signs and Symptoms (215) · Pathologic Processes (154) · Infections (141) · Bacterial Infections and Mycoses (98) · Disease Attributes (97) · Nutritional and Metabolic Diseases (90) · Bacterial Infections (83) · Metabolic Diseases (83)
ivacaftor (108) · elexacaftor, ivacaftor, tezacaftor drug combination (36) · Inhalation (25) · Exercise (24) · Sodium Chloride (23) · tezacaftor, ivacaftor drug combination (22) · Tobramycin (21) · Saline Solution, Hypertonic (20) · tezacaftor (20) · Blood Specimen Collection (19) · lumacaftor, ivacaftor drug combination (19) · Surveys and Questionnaires (15) · lumacaftor (15) · Cholecalciferol (13) · Pancrelipase (13)
Vertex Pharmaceuticals Incorporated (117) · Hospices Civils de Lyon (33) · Assistance Publique - Hôpitaux de Paris (31) · Gilead Sciences (22) · National Jewish Health (21) · University of North Carolina, Chapel Hill (20) · Children's Hospital Medical Center, Cincinnati (17) · The Hospital for Sick Children (17) · University of Alabama at Birmingham (17) · Novartis Pharmaceuticals (16) · Royal Brompton & Harefield NHS Foundation Trust (16) · University Hospital, Montpellier (16) · University of British Columbia (16) · Boston Children's Hospital (15) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (15)
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Felix Ratjen, MD (9) · Margaret Rosenfeld, MD, MPH (8) · Eitan Kerem, MD (6) · Gina Eagle, MD (6) · Scott Donaldson, MD (6) · Alan Smyth (5) · Jason Woods, PhD (5) · Nicole Mayer-Hamblett, PhD (5) · Amy Schaberg, BSN (4) · Antoinette Moran, MD (4)
PMID 37983082, PMID 33331662, PMID 33735508, PMID 37319354, PMID 32671834, PMID 27009167, PMID 31215818, PMID 32761612, PMID 36509366, PMID 36511181, PMID 25981758, PMID 33331663, PMID 36866921, PMID 15065835, PMID 19717485, PMID 22805498, PMID 24464974, PMID 24743971, PMID 25819269, PMID 26070913, PMID 26709158, PMID 27298017, PMID 30146268, PMID 30334693, PMID 30587335, PMID 31056441, PMID 32358807, PMID 33105385, PMID 33303537, PMID 34929010, PMID 35227647, PMID 36625789, PMID 36842446, PMID 37683122, PMID 38145393, PMID 39255452, PMID 39756424, PMID 10459902, PMID 11013547, PMID 11179102, PMID 11344348, PMID 11451820, PMID 11562511, PMID 11742607, PMID 11809990, PMID 11834520, PMID 11866011, PMID 11921459, PMID 12004158, PMID 12052307
2017 (16), 2018 (15), 2019 (11), 2015 (10), 2016 (10), 2014 (8), 2008 (7), 2009 (7), 2023 (5), UL1TR001082 (3), P50HL084932 (2), R01HL108929 (2), R01HL116226 (2), R01HL131012 (2), R01HL161164 (2)