37 unknown. 37 Phase 3, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 37 | Unknown 37 |
| Phase 2 | 10 | Unknown 10 |
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients Esketamine, Saline, Remifentanil + propofol - Septic Shock, Mechanical Ventilation Complication | Phase 3 | Unknown | Nanfang Hospital, Southern Medical University | 124 | 2023-05-31 | 2023-11-22 |
| Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit Piperacillin/tazobactam or temocillin, Meropenem - Sepsis, Septic Shock | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 600 | 2023-03-11 | 2023-04-18 |
| Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic Shock Noradrenaline plus Terlipressin - Septic Shock | Phase 3 | Unknown | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 152 | 2022-10-11 | 2023-04-27 |
| Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01) Aminoglycosides intervention, Lack of protective isolation intervention, No systematic aminoglycosides intervention - standard arm - Sepsis, Septic Shock | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 340 | 2022-09-01 | 2022-07-05 |
| Ivabradine Effects in Cardiogenic Shock Requiring Inotropic Support Ivabradine 7.5Mg Tab, DOBUTamine Injectable Solution - Heart Failure, Cardiogenic Shock | Phase 3 | Unknown | The Young Investigator Group of Cardiovascular Research | 200 | 2022-07-01 | 2022-10-26 |
| PROlectin M, a Nucleocapsid TErminal GaleCTin Antagonist for COVID-19 Galactomannan, PLACEBO - COVID-19, COVID-19 Pandemic | Phase 3 | Unknown | Bioxytran Inc. | 408 | 2022-04-01 | 2022-03-09 |
| Plasma Exchange in Covid-19 Patients With Anti-interferon Autoantibodies Therapeutic plasma exchange - COVID-19 | Phase 3 | Unknown | Centre Hospitalier St Anne | 50 | 2021-12-22 | 2022-01-10 |
| Efficacy and Safety of EXOSOME-MSC Therapy to Reduce Hyper-inflammation In Moderate COVID-19 Patients Exosome-MSC Intravenous injection, Placebo Intravenous Injection, COVID-19 Standard Treatment - SARS-CoV2 Infection | Phase 2 / Phase 3 | Unknown | Dermama Bioteknologi Laboratorium | 60 | 2021-07-01 | 2022-02-18 |
| Anti-inflammatory/Antioxidant Oral Nutrition Supplementation in COVID-19 Oral supplement enriched in antioxidants, cellulose-containing placebo capsules - COVID-19 | Phase 2 / Phase 3 | Unknown | King Saud University | 40 | 2020-09-01 | 2020-09-22 |
| Best Supportive Care With or Without Low Dose Whole Lung Radiation Therapy for the Treatment of COVID-19 Best Practice, Low Dose Radiation Therapy - Pneumonia, Severe Acute Respiratory Syndrome | Phase 3 | Unknown | Emory University | 14 | 2020-06-23 | 2023-08-14 |
| The Safety & Efficacy of Imatinib for the Treatment of SARS-COV-2 Induced Pneumonia Imatinib Mesylate, Standard of Care - COVID-19 | Phase 3 | Unknown | Alexandria University | 30 | 2020-06-01 | 2020-06-09 |
| Phase 3 Study to Evaluate Efficacy and Safety of Lenzilumab in Patients With COVID-19 Lenzilumab, Standard of Care - Coronavirus Disease 2019 (COVID-19) Pneumonia | Phase 3 | Unknown | Humanigen, Inc. | 520 | 2020-05-05 | 2021-03-03 |
| Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock. IgM-enriched polyclonal immunoglobulins titer-based treatment, IgM-enriched polyclonal immunoglobulins Flat treatment - Shock, Septic, Sepsis | Phase 3 | Unknown | Massimo Girardis | 356 | 2020-05-01 | 2021-05-06 |
| Oral 25-hydroxyvitamin D3 and COVID-19 Oral 25-Hydroxyvitamin D3 - COVID 19 | Phase 2 / Phase 3 | Unknown | Tehran University of Medical Sciences | 1500 | 2020-04-14 | 2020-06-12 |
| Methylene Blue and Microcirculation in Septic Shock Methylene Blue, Norepinephrine infusion - Septic Shock | Phase 3 | Unknown | Cairo University | 32 | 2020-03-10 | 2020-03-05 |
| Steroids, Thiamine and Ascorbic Acid in Septic Shock STASIS - Septic Shock | Phase 3 | Unknown | Baqiyatallah Medical Sciences University | 80 | 2019-12-01 | 2019-10-22 |
| Volume Expansion With Albumin vs. Crystalloid and Expiratory Lung Impedance Fluid loading with Albumin, Fluid loading with Ringer Lactate - Circulatory Failure | Phase 2 / Phase 3 | Unknown | University of Milan | 56 | 2019-07-24 | 2019-07-30 |
| Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients Probiotics, Placebo - Acute Kidney Injury, Probiotics | Phase 3 | Unknown | Hospital Civil de Guadalajara | 90 | 2019-01-04 | 2021-08-25 |
| Treatment of Severe Infection With Antihyperlipidemia Drug Alirocumab Injectable Product, Saline Solution - Sepsis, Septic Shock | Phase 2 / Phase 3 | Unknown | Wolfson Medical Center | 712 | 2019-01-01 | 2018-08-16 |
| Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients Ketamine full dose, Ketamine half dose, Lidocaine - Septic Shock, Anesthesia | Phase 3 | Unknown | Cairo University | 36 | 2018-12-20 | 2018-11-21 |
Showing 20 of 37. Sign in to see all of them.
Shock, Septic (19) · Sepsis (15) · COVID-19 (8) · Cytokine Release Syndrome (8) · Pneumonia (4) · Shock, Cardiogenic (3) · Heart Failure (2) · Multiple Organ Failure (2) · Systemic Inflammatory Response Syndrome (2) · Acute Kidney Injury (1) · Adrenal Insufficiency (1) · Agnosia (1) · Atrial Fibrillation (1) · Bronchopulmonary Dysplasia (1)
Pathologic Processes (37) · Pathological Conditions, Signs and Symptoms (37) · Inflammation (31) · Infections (30) · Systemic Inflammatory Response Syndrome (29) · Lung Diseases (9) · Respiratory Tract Diseases (9) · Coronaviridae Infections (8) · Coronavirus Infections (8) · Nidovirales Infections (8) · Pneumonia, Viral (8) · RNA Virus Infections (8) · Respiratory Tract Infections (8) · Sepsis (8)
Norepinephrine (4) · Dobutamine (3) · Saline Solution (3) · Standard of Care (3) · Melatonin (2) · Methylene Blue (2) · Terlipressin (2) · Acetylcysteine (1) · Adrenergic beta-Antagonists (1) · Alanine (1) · Albumins (1) · Amiodarone (1) · Antioxidants (1) · Calcifediol (1) · Dexmedetomidine (1)
Cairo University (3) · Assistance Publique - Hôpitaux de Paris (2) · Alexandria University (1) · American British Cowdray Medical Center (1) · Amsterdam UMC, location VUmc (1) · Aragon Institute of Health Sciences (1) · Baqiyatallah Medical Sciences University (1) · Belinda Howe (1) · Bioxytran Inc. (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier St Anne (1) · Dermama Bioteknologi Laboratorium (1) · Emory University (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Hospital Civil de Guadalajara (1)
Brazil (4) · Egypt (4) · United States (4) · France (3) · Australia (2) · China (2) · Italy (2) · Mexico (2) · Netherlands (2) · Spain (2) · Finland (1) · Hong Kong (1) · Indonesia (1) · Iran (1) · Ireland (1)
Ahmed Hasanin, Professor (1) · Ahmed Mukhtar, Professor (1) · Alfredo Aisa Alvarez, MD (1) · Amir Vahedian-Azimi, PhD (1) · Andrew C Miller, MD (1) · Arash Shirvani, MD, PhD (1) · Bambang Darwono, Dr.Sp.OT (1) · Cameron Durrant, MD (1) · Davide Chiumello, MD (1) · Indah H Kampono, Dr. Sp.DV (1) · Kyuseok Kim, MD (1) · Martijn Poeze, MD, PhD (1)
PMID 19228496, PMID 24099368, PMID 25272316, PMID 25947955, PMID 30985391, PMID 33006765, PMID 33153629, PMID 33574139, PMID 33673929, PMID 33757717, PMID 33972949, PMID 34863332, PMID 35793833, PMID 37174730, PMID 37724527, PMID 38046082
2017 (1), 2018 (1), K08HD052885 (1), P30CA138292 (1)