20 completed. 20 Phase 1, 14 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 20 |
| Phase 2 | 14 | Completed 14 |
Follow Septic Shock: new trials by email Literature Review of Septic Shock trials Research Report on Septic Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis apigenin, sterilized water - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Zhujiang Hospital | 20 | 2023-09-01 | 2024-03-13 |
| Intravenously Administered M6229 in Critically Ill Sepsis Patients M6229 - Sepsis, Septic Shock | Phase 1 | Completed | A.P.J. Vlaar | 10 | 2022-04-05 | 2025-02-11 |
| Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis Therapeutic plasma exchange - Septic Shock | Phase 1 | Completed | Alberta Health Services, Calgary | 17 | 2020-10-21 | 2025-10-03 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2023-10-10 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2022-07-06 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2023-10-10 |
| LIPIDS-P Trial Phase I/II Trial Smoflipid - Sepsis, Severe, Septic Shock | Phase 1 / Phase 2 | Completed | University of Florida | 59 | 2018-08-17 | 2025-08-11 |
| Effect of Mesenchymal Stromal Cells on Sepsis and Septic Shock Mesenchymal stem cells - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | TC Erciyes University | 30 | 2018-03-11 | 2022-03-16 |
| The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis Remote ischemic conditioning - Septic Shock, Sepsis | Phase 1 / Phase 2 | Completed | Lithuanian University of Health Sciences | 26 | 2018-02-01 | 2021-03-03 |
| Cellular Immunotherapy for Septic Shock: A Phase I Trial Allogeneic mesenchymal stromal cells - Septic Shock | Phase 1 | Completed | Ottawa Hospital Research Institute | 9 | 2015-05-01 | 2018-10-31 |
| Anisodamine Critically Ill SeptIc Shock anisodamine - Septic Shock | Phase 1 / Phase 2 | Completed | Jinhua Central Hospital | 355 | 2015-04-01 | 2021-09-29 |
| The Effect of Midazolam on Fluid Responsiveness in Septic Patients sedatives(Midazolam and Propofol) - Septic Shock | Phase 1 / Phase 2 | Completed | Southeast University, China | 40 | 2012-05-01 | 2014-01-31 |
| Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome PiCCO monitoring (PULSION), central venous catheter - Septic Shock, Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Completed | Jinhua Central Hospital | 350 | 2012-01-01 | 2015-05-04 |
| Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock Pioglitazone hydrochloride - Severe Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 12 | 2011-10-01 | 2020-09-02 |
| Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study Angiotensin II - Septic Shock | Phase 1 | Completed | George Washington University | 20 | 2011-07-01 | 2024-04-12 |
| Ascorbic Acid (Vitamin C) Infusion in Human Sepsis Ascorbic Acid, Placebo - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | 24 | 2010-05-01 | 2018-02-01 |
| Thiamine as a Metabolic Resuscitator in Septic Shock D5W, Thiamine - Septic Shock | Phase 1 / Phase 2 | Completed | Beth Israel Deaconess Medical Center | 88 | 2010-02-01 | 2017-05-15 |
| Rapid Administration of Insulin in Sepsis GIK - Septic Shock | Phase 1 | Completed | Wake Forest University Health Sciences | 20 | 2009-03-01 | 2022-04-25 |
| Acetyl-L-Carnitine in the Treatment of Septic Shock Acetyl-L-Carnitine - Septic Shock | Phase 1 / Phase 2 | Completed | Vanderbilt University | 13 | 2006-08-01 | 2017-12-08 |
| Effects of Endotoxin in Normal Human Volunteers Reference Endotoxin, Inhaled Nitric Oxide - Healthy, Lung Disease | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 198 | 1992-04-06 | 2018-07-05 |
Shock, Septic (20) · Sepsis (12) · Acute Lung Injury (1) · Critical Illness (1) · Hyperphagia (1) · Hypotension (1) · Inflammation (1) · Lung Diseases (1) · Respiratory Distress Syndrome (1)
Infections (20) · Pathologic Processes (20) · Pathological Conditions, Signs and Symptoms (20) · Shock (20) · Systemic Inflammatory Response Syndrome (20) · Inflammation (19) · Sepsis (8) · Respiratory Tract Diseases (3) · Lung Diseases (2) · Cardiovascular Diseases (1) · Disease Attributes (1) · Lung Injury (1) · Respiration Disorders (1) · Signs and Symptoms (1) · Signs and Symptoms, Digestive (1)
Bronchoscopy (3) · Meropenem (3) · Ventilators, Mechanical (3) · 2-(phenylmethyl)-1-naphthol (1) · Acetylcarnitine (1) · Angiotensin II (1) · Apigenin (1) · Ascorbic Acid (1) · Central Venous Catheters (1) · Parenteral Nutrition, Total (1) · Pioglitazone (1) · Plasma Exchange (1) · Propofol (1) · SMOFlipid (1) · Thiamine (1)
King Abdul Aziz Specialist Hospital (3) · Jinhua Central Hospital (2) · A.P.J. Vlaar (1) · Alberta Health Services, Calgary (1) · Beth Israel Deaconess Medical Center (1) · Children's Hospital Medical Center, Cincinnati (1) · George Washington University (1) · Lithuanian University of Health Sciences (1) · National Institutes of Health Clinical Center (CC) (1) · Ottawa Hospital Research Institute (1) · Southeast University, China (1) · TC Erciyes University (1) · University of Florida (1) · Vanderbilt University (1) · Virginia Commonwealth University (1)
United States (8) · China (4) · Saudi Arabia (3) · Canada (2) · Lithuania (1) · Netherlands (1) · Turkey (Türkiye) (1)
Alan E Jones, MD (1) · Alexander P Vlaar, MD, PhD, MBA (1) · Alpha Fowler, MD (1) · Anthony F Suffredini, M.D. (1) · Faheem W Guirgis, MD (1) · George F Alvarez, MD (1) · Jennifer M. Kaplan, M.D., M.S. (1) · Lakhmir Chawla, MD (1) · Lauralyn McIntyre, MD (1) · Michael W Donnino, MD (1) · Todd W. Rice, MD, MSc (1) · Zhanguo Liu, M.D.PhD (1) · Zhongheng Zhang, MD (1)
PMID 23374652, PMID 24484547, PMID 25286986, PMID 26605292, PMID 28203424, PMID 28960096, PMID 30255316, PMID 31537565, PMID 33392541, PMID 33829305, PMID 34579741, PMID 35784641, PMID 38321529, PMID 38488429, PMID 39716214