10 not yet recruiting, 8 recruiting, 7 completed, 2 enrolling by invitation. 18 Not applicable, 2 Phase 3, 1 Phase 1, 1 Phase 2.
Follow Schizophrenia Disorder: new trials by email Literature Review of Schizophrenia Disorder trials Research Report on Schizophrenia Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome Semaglutide + TAU, Placebo + TAU - Schizophrenia Disorder, Metabolic Syndrome | Phase 3 | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | 600 | 2026-12-01 | 2026-08-18 |
| DecNef for Auditory Verbal Hallucinations (AVH) in Schizophrenia Decoded Neurofeedback - Schizophrenia Disorder, Schizoaffecitve Disorder | Not applicable | Not yet recruiting | Columbia University | 51 | 2026-12-01 | 2026-10-14 |
| A Prospective, Observational, Single-Arm, Multicenter Real-World Study Evaluating the Treatment Pattern, Safety and Effectiveness of Xanomeline and Trospium Chloride Capsules (KarXT) in the Treatment of Chinese Adult Participants With Schizophrenia Xanomeline and trospium chloride (KarXT) - Schizophrenia Disorder | Not yet recruiting | Zai Lab (Shanghai) Co., Ltd. | 250 | 2026-09-20 | 2026-09-03 | |
| Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia Accelerated iTBS, High-Frequency rTMS, Sham rTMS - Psychosis, Schizophrenia Disorder | Not applicable | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | 90 | 2026-09-15 | 2026-08-10 |
| Medication Adherence in Severe Mental Illness: a Promotion Program Telehealth Psychoeducational Adherence Program - Treatment Adherence and Compliance, Severe Mental Disorders | Not applicable | Not yet recruiting | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 1640 | 2026-09-01 | 2026-03-03 |
| Reducing Mental Health Stigmatization Among Healthcare Workers and Students Using a Virtual Reality Protocol: The VIRTUS Protocol VIRTUS, VR Control - Schizophrenia Disorder | Not applicable | Recruiting | Centre Hospitalier Henri Laborit | 128 | 2026-08-17 | 2026-10-22 |
| A Positron Emission Tomography (PET) Study to Evaluate Dopamine D2 and D3 Receptor Occupancy by SIPI6398 SIPI6398 Tablets - Schizophrenia Disorder | Phase 1 / Phase 2 | Not yet recruiting | Shanghai Zhongze Therapeutics Co., Ltd. | 9 | 2026-08-01 | 2026-06-04 |
| Cognitive Strategies in Early Psychosis 2 Modafinil, D-serine solution, Placebo - Psychosis, Schizophrenia Disorder | Phase 3 | Recruiting | University of Minnesota | 24 | 2026-07-17 | 2026-07-23 |
| Understanding and Treating Severe and Resistant Pathological Aggression: Using Deep Brain Stimulation to Treat Resistant Aggression neurostimulator - Autism Spectrum Disorder, Schizophrenia Disorder | Not applicable | Not yet recruiting | University Hospital, Rouen | 6 | 2026-07-13 | 2026-06-08 |
| MicroRNAs as Biomarkers in First Episode Schizophrenia Plasma NDE miRNA Sequencing, Whole Genome Sequencing - Schizophrenia Disorder, Schizophreniform Disorder | Not applicable | Recruiting | Northwell Health | 160 | 2026-07-01 | 2026-07-14 |
| dACC-Targeted Temporal Interference for Negative and Cognitive Symptoms in Schizophrenia Temporal Interference Stimulation, Sham Temporal Interference Stimulation - Schizophrenia Disorder | Not applicable | Recruiting | Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University | 74 | 2026-06-30 | 2026-08-21 |
| TIS for Improving Cognitive Impairment in Schizophrenia temporal interference stimulation, Sham stimulation - Schizophrenia Disorder, Cognitive Impairments | Not applicable | Recruiting | Central South University | 50 | 2026-06-24 | 2026-07-17 |
| A Virtual Reality Mindfulness Application for Aggression in Schizophrenia Mindfulness-Based Virtual Reality Intervention - Schizophrenia Disorder, Schizoaffecitve Disorder | Not applicable | Recruiting | Manhattan Psychiatric Center | 58 | 2026-06-05 | 2026-06-10 |
| Mechanisms of Sulforaphane Supplementation in Alleviating Negative Symptoms and Cognitive Impairment in Schizophrenia Placebo, Sulforaphane - Schizophrenia Disorder | Not applicable | Not yet recruiting | Second Xiangya Hospital of Central South University | 60 | 2026-06-02 | 2026-06-18 |
| Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization Financial incentives for adherence to long-acting injectable medication, Standard of care with monthly surveys - Schizophrenia Disorder, Schizoaffective Disorder | Not applicable | Enrolling by invitation | Stanford University | 1000 | 2026-03-09 | 2026-10-23 |
| Improving Health Literacy in Patients With Schizophrenia Spectrum Disorder Educational sessions - Schizophrenia Disorder, Schizoaffective Disorder | Not applicable | Not yet recruiting | Louisiana State University Health Sciences Center in New Orleans | 34 | 2026-03-01 | 2026-03-23 |
| Inter-Brain Synchrony in Schizophrenia Fast Friends, Small Talk - Schizophrenia Disorder | Not applicable | Recruiting | University of California, Los Angeles | 100 | 2025-11-11 | 2026-08-11 |
| AI-assisted Masticatory Muscle Training in Patients With Schizophrenia AI-assisted Mastisting Training App - Schizophrenia Disorder | Not applicable | Not yet recruiting | Kaohsiung Medical University Chung-Ho Memorial Hospital | 100 | 2025-09-11 | 2025-09-04 |
| Assessment of Physical Activity, Balance, Muscle Strength, and Cognitive Function in Patients Diagnosed With Schizophrenia Schizophrenia Disorder | Completed | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 35 | 2025-08-19 | 2026-08-19 | |
| Physical Fitness, Physical Activity Level, Depression and Quality of Life in Bipolar and Schizophrenia Patients Survey - Bipolar Disorder (BD), Schizophrenia Disorder | Completed | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 62 | 2025-06-23 | 2025-08-24 |
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Schizophrenia (29) · Bipolar Disorder (5) · Psychotic Disorders (5) · Mental Disorders (3) · Aggression (1) · Alzheimer Disease (1) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Depressive Disorder, Major (1) · Emotional Regulation (1) · Generalized Anxiety Disorder (1) · Hallucinations (1) · Insulin Resistance (1)
Schizophrenia Spectrum and Other Psychotic Disorders (29) · Mental Disorders (26) · Behavior (5) · Bipolar and Related Disorders (5) · Mood Disorders (5) · Neurocognitive Disorders (3) · Health Behavior (2) · Nervous System Diseases (2) · Social Behavior (2) · Aberrant Motor Behavior in Dementia (1) · Behavioral Symptoms (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Chemically-Induced Disorders (1) · Child Development Disorders, Pervasive (1)
3-carboxamido-4-hydroxynaltrexone (1) · Cognitive Behavioral Therapy (1) · Implantable Neurostimulators (1) · Modafinil (1) · Olanzapine (1) · Risperidone (1) · Standard of Care (1) · Surveys and Questionnaires (1) · Whole Genome Sequencing (1) · lybalvi (1) · semaglutide (1) · sulforaphane (1) · trospium chloride (1) · xanomeline (1)
All India Institute of Medical Sciences, Bhubaneswar (2) · Dr. Lutfi Kirdar Kartal Training and Research Hospital (2) · Alkermes, Inc. (1) · Central South University (1) · Centre Hospitalier Henri Laborit (1) · Columbia University (1) · Dokuz Eylul University (1) · Elazığ Mental Health and Diseases Hospital (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Halic University (1) · Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (1) · Kaohsiung Medical University Chung-Ho Memorial Hospital (1) · Louisiana State University Health Sciences Center in New Orleans (1) · Manhattan Psychiatric Center (1) · Northwell Health (1)
United States (8) · Turkey (Türkiye) (6) · China (4) · France (2) · Denmark (1) · India (1) · Israel (1) · Spain (1)
Antoine Douaihy, MD (1) · Anzalee Khan, PhD (1) · Caroline Demro, Ph.D. (1) · Eric Reavis, Phd (1) · Guillermo Horga, MD, PhD (1) · Hsieh Hsiu Fen, PhD (1) · Jean-Pierre Lindenmayer, MD (1) · Jonathan K Wynn, PhD (1) · Joshua Kantrowitz, MD (1) · Juan Gallego, MD (1) · Shahak Yariv, MD (1) · Sophia Vinogradov, MD (1)
PMID 23714262, PMID 28078204, PMID 31077729, PMID 31150942, PMID 33761085, PMID 34639510, PMID 42556844, PMID 42745898
P50MH119569 (1), R21MH139044 (1), R61MH133785 (1), R61MH143195 (1)