789 completed, 198 unknown, 154 recruiting, 69 terminated. 1336 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 1336 | Completed 789, Unknown 198, Recruiting 154, Terminated 69, Not yet recruiting 67, Withdrawn 26, Active not recruiting 21, Enrolling by invitation 9, Suspended 3 |
Follow Schizophrenia: new trials by email Literature Review of Schizophrenia trials Research Report on Schizophrenia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module - Severe Mental Illness, Depression / Major Depressive Disorder | Not applicable | Not yet recruiting | Ludwig-Maximilians - University of Munich | 140 | 2028-10-01 | 2026-05-14 |
| Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2 Motion Perception Task, Sine Wave Speech Task, Volatility Task - SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder | Not applicable | Not yet recruiting | Washington University School of Medicine | 325 | 2028-04-01 | 2026-10-23 |
| Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis MANOEUVRE therapy - Psychosis, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Not yet recruiting | King's College London | 15 | 2027-09-01 | 2026-06-03 |
| Improving Quality of Informal Care for People With Schizophrenia Dyadic Multicomponent Intervention (DMI), Dyadic Benefit-Finding Intervention (DBFI) - Schizophrenia | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 228 | 2027-07-01 | 2026-08-25 |
| Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia Insightec Exablate Neuro MR-guided focused ultrasound transducer - Treatment-resistant Schizophrenia | Not applicable | Suspended | NYU Langone Health | 3 | 2027-06-01 | 2026-04-02 |
| Feasibility and Acceptability of Mobile Mental Health App for SZ and SZA Intervention via mobile application - Schizophrenia, Schizo Affective Disorder | Not applicable | Not yet recruiting | University of Pittsburgh | 44 | 2027-06-01 | 2026-09-16 |
| Prucalopride for Cognitive Functioning in Schizophrenia Prucalopride 1 MG - Schizophrenia | Not applicable | Not yet recruiting | University of Pittsburgh | 34 | 2027-05-31 | 2026-09-17 |
| Feasibility Trial of a Parent Peer-Co-Led Caregiver Group for Pediatric Early Onset Schizophrenia Spectrum Disorders Group Therapy, Treatment as Usual (TAU) - Schizophrenia; Psychosis | Not applicable | Not yet recruiting | Boston Children's Hospital | 20 | 2027-05-01 | 2026-10-09 |
| Frontal Gamma Coherence Neurofeedback for Patients With Schizophrenia Frontal gamma coherence neurofeedback, Placebo Neurofeedback - Schizophrenia, Schizoaffective | Not applicable | Not yet recruiting | BioSignal Solutions LLC | 30 | 2027-04-01 | 2026-09-24 |
| NST-SPARK Open-Label Phase 1 STTR (IGNITE) NST-SPARK - Schizophrenia / Schizoaffective Disorder | Not applicable | Not yet recruiting | North Shore Therapeutics, Inc. | 30 | 2027-03-01 | 2026-05-18 |
| LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI) LIFU - Schizophrenia, Auditory Hallucinations | Not applicable | Not yet recruiting | University of California, San Francisco | 12 | 2027-02-01 | 2026-08-05 |
| Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia, Bipolar Disorder | Not applicable | Not yet recruiting | Central South University | 400 | 2027-01-01 | 2026-03-04 |
| Shared Decision Making for Antipsychotic Medications The Antipsychotic Medication Decision Aid (APM-DA) - Schizophrenia, Schizoaffective Disorder | Not applicable | Not yet recruiting | New York State Psychiatric Institute | 120 | 2027-01-01 | 2026-03-30 |
| DecNef for Auditory Verbal Hallucinations (AVH) in Schizophrenia Decoded Neurofeedback - Schizophrenia Disorder, Schizoaffecitve Disorder | Not applicable | Not yet recruiting | Columbia University | 51 | 2026-12-01 | 2026-10-14 |
| Mobile Thinking Intervention: A Inital Test Mobile Intervention for Biased Thinking - Schizophrenia, Clinical High Risk for Psychosis (CHR) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 100 | 2026-12-01 | 2026-10-13 |
| Online Intervention To Improve Motivation Online Motivation Enhancing Intervention - Schizophrenia Prodromal, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2026-12-01 | 2026-10-13 |
| Gamma Light and Sound Stimulation in Schizophrenia GENUS, Sham Stimulation - Schizophrenia Spectrum Disorders | Not applicable | Not yet recruiting | Massachusetts Institute of Technology | 20 | 2026-12-01 | 2026-10-07 |
| Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3 Motion Perception Task, Sine Wave Speech Task, Volatility Task - Schizophrenia / Schizoaffective Disorder, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Recruiting | Washington University School of Medicine | 10000 | 2026-12-01 | 2026-10-28 |
| NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia Perceptual Discrimination Training, Cognitive Control Training - Schizophrenia, Schizoaffective Disorder | Not applicable | Not yet recruiting | University of Minnesota | 168 | 2026-11-02 | 2026-10-02 |
| A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness MoodSync, Standard care - Severe Mental Illness, Bipolar Disorder | Not applicable | Not yet recruiting | Alexandria University | 60 | 2026-11-01 | 2026-10-16 |
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Psychotic Disorders (475) · Bipolar Disorder (189) · Mental Disorders (105) · Depressive Disorder, Major (71) · Hallucinations (64) · Depression (44) · Motor Activity (38) · Cognitive Dysfunction (37) · Obesity (28) · Schizophrenia, Treatment-Resistant (26) · Metabolic Syndrome (23) · Schizophrenia, Paranoid (23) · Schizophrenia Spectrum and Other Psychotic Disorders (21) · Cognition Disorders (20)
Schizophrenia Spectrum and Other Psychotic Disorders (1315) · Mental Disorders (1231) · Behavior (228) · Mood Disorders (205) · Bipolar and Related Disorders (187) · Pathological Conditions, Signs and Symptoms (179) · Signs and Symptoms (156) · Nervous System Diseases (131) · Neurologic Manifestations (109) · Neurobehavioral Manifestations (89) · Depressive Disorder (72) · Behavioral Symptoms (71) · Perceptual Disorders (68) · Nutritional and Metabolic Diseases (64) · Neurocognitive Disorders (59)
Therapeutics (64) · Transcranial Direct Current Stimulation (55) · Transcranial Magnetic Stimulation (51) · Cognitive Remediation (36) · Exercise (30) · Cognitive Behavioral Therapy (29) · Cognitive Training (25) · Risperidone (25) · Olanzapine (22) · Aripiprazole (13) · Oxytocin (10) · Haloperidol (9) · Clozapine (8) · Quetiapine Fumarate (8) · Standard of Care (8)
Centre for Addiction and Mental Health (40) · VA Office of Research and Development (37) · Shanghai Mental Health Center (34) · University of Maryland, Baltimore (31) · Hôpital le Vinatier (30) · Yale University (21) · Dartmouth-Hitchcock Medical Center (19) · US Department of Veterans Affairs (18) · University of California, San Diego (18) · Central South University (16) · Massachusetts General Hospital (14) · New York State Psychiatric Institute (13) · Northwell Health (13) · Centre Hospitalier St Anne (12) · King's College London (12)
United States (474) · France (141) · China (98) · Canada (82) · Germany (57) · Taiwan (54) · Turkey (Türkiye) (52) · Spain (43) · Denmark (38) · Israel (30) · United Kingdom (23) · Switzerland (17) · Hong Kong (16) · Norway (16) · India (13)
Sophia Vinogradov, MD (7) · Xiaoming Du, PhD (7) · Dror Ben-Zeev, PhD (6) · Eric Granholm, PhD (6) · Hsin-An Chang, M.D. (6) · Jun Cai (6) · Martha Sajatovic, MD (5) · Brandon Gaudiano, PhD (4) · Cenk Tek, M.D. (4) · Eric L. Granholm, PhD (4) · Herbert Y Meltzer, M.D. (4) · Jean-Pierre Lindenmayer, MD (4) · Sebastian Walther, MD (4) · Alexander Stehle Young, MD MSHS (3) · Alice Medalia, PhD (3)
PMID 33539561, PMID 32476658, PMID 34689733, PMID 41130742, PMID 42393474, PMID 32336984, PMID 33861952, PMID 33914891, PMID 36418846, PMID 36711165, PMID 39117276, PMID 40063391, PMID 42184934, PMID 15367925, PMID 17375138, PMID 20008941, PMID 20658320, PMID 21334602, PMID 22710617, PMID 23522057, PMID 23817024, PMID 25083802, PMID 25273286, PMID 25582269, PMID 25979608, PMID 26160288, PMID 26200928, PMID 26494483, PMID 27780336, PMID 27868083, PMID 28406662, PMID 28740827, PMID 29525739, PMID 30260448, PMID 30326433, PMID 30420252, PMID 30627303, PMID 30704863, PMID 30921747, PMID 30953588, PMID 31811557, PMID 31928566, PMID 32799938, PMID 33878489, PMID 35128308, PMID 36173600, PMID 36931706, PMID 37314113, PMID 38616053, PMID 39959603
2018 (3), D43TW009114 (3), R01MH084840 (3), I01RX000180 (2), K23DA050808 (2), K23MH119318 (2), P30MH082760 (2), P50MH115843 (2), R01MH064662 (2), R01MH067073 (2), R01MH073673 (2), R01MH077210 (2), R34MH111852 (2), R34MH129552 (2), 1IK2RX001836-01A1 (1)