5 completed, 2 not yet recruiting, 2 recruiting, 1 active not recruiting. 4 Phase 4, 3 Phase 2, 3 Phase 3, 1 Not applicable, 1 Phase 1.
Follow Penicillin G Benzathine: new trials by email Literature Review of Penicillin G Benzathine trials Research Report on Penicillin G Benzathine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases | Not applicable | Not yet recruiting | Ladoke Akintola University of Technology, Ogbomoso, Nigeria | 474 | 2027-01-05 | 2026-06-04 |
| Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates Benzathine Penicillin, Amoxicillin - Syphilis, Congenital | Phase 4 | Not yet recruiting | University of Alabama at Birmingham | 374 | 2026-11-01 | 2026-09-02 |
| Effect and Safety of Benzathine Penicillin Combined With Etanercept on Spondyloarthritis Etanercept, Benzathine Penicillin, Placebo - Spondyloarthritis (SpA), Ankylosing Spondylitis (AS) | Phase 4 | Recruiting | Nanfang Hospital, Southern Medical University | 340 | 2025-06-14 | 2025-06-26 |
| Linezolid for Syphilis Pilot Study Group B, Linezolid 10d, Group A, Penicillin - Syphilis | Phase 2 | Active not recruiting | University of Southern California | 24 | 2023-09-28 | 2026-03-12 |
| A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post) Penicillin G Benzathine - Rheumatic Heart Disease | Completed | Children's Hospital Medical Center, Cincinnati | 1423 | 2022-01-28 | 2024-08-27 | |
| Cefixime Clinical Trial Cefixime 400mg, benzathine penicillin - Syphilis, Human Immunodeficiency Virus | Phase 3 | Recruiting | University of Southern California | 400 | 2021-06-20 | 2026-05-04 |
| Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection Benzathine Penicillin - Syphilis | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 249 | 2018-10-31 | 2025-01-14 |
| A Study of Benzathine Benzylpenicillin Intramuscular Injection in Japanese Healthy Subjects penicillin G benzathine - Healthy | Phase 1 | Completed | Pfizer | 8 | 2018-08-20 | 2018-10-10 |
| Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin benzathine penicillin - Syphilis | Phase 4 | Unknown | Peking Union Medical College Hospital | 150 | 2016-08-01 | 2018-11-16 |
| Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS Sertraline+Antibiotic (penicillin/azithromycin), Sertraline+placebo, IVIG - Pandas | Phase 2 | Withdrawn | CNS Onlus | 2013-06-01 | 2023-02-21 | |
| Single-dose Azithromycin for the Treatment of Yaws Penicillin-G-benzathine, Azithromycin - Yaws, Treponema Infection | Phase 3 | Completed | Lihir Medical Centre | 255 | 2010-09-01 | 2012-04-13 |
| Bicillin L-A vs Placebo for the Treatment of Chronic, Plaque-Type Psoriasis Unresponsive to Topical Medications Bicillin L-A - Psoriasis | Phase 2 | Terminated | University of Tennessee | 5 | 2007-01-01 | 2015-04-21 |
| Azithromycin/Bicillin Syphilis Azithromycin, Benzathine Penicillin, Doxycycline - Syphilis | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 593 | 2000-06-01 | 2013-04-29 |
Syphilis (5) · Treponemal Infections (3) · Acquired Immunodeficiency Syndrome (1) · Heart Valve Diseases (1) · Neglected Diseases (1) · Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (1) · Psoriasis (1) · Rheumatic Fever (1) · Rheumatic Heart Disease (1) · Spondylarthritis (1) · Spondylitis, Ankylosing (1) · Syphilis, Congenital (1) · Yaws (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · University of Southern California (2) · CNS Onlus (1) · Children's Hospital Medical Center, Cincinnati (1) · Ladoke Akintola University of Technology, Ogbomoso, Nigeria (1) · Lihir Medical Centre (1) · Nanfang Hospital, Southern Medical University (1) · Peking Union Medical College Hospital (1) · Pfizer (1) · University of Alabama at Birmingham (1) · University of Tennessee (1)
United States (6) · China (2) · Japan (1) · Madagascar (1) · Papua New Guinea (1) · Uganda (1)
Jeffrey D Klausner, MD MPH (2) · Adeseye A Akintunde (1) · Andrea Z Beaton, MD (1) · David Kimberlin, MD (1) · Elias Rosenberg, MD (1) · Jodie Dionne, MD (1) · Quique Bassat, MD, PhD (1) · Stefano Pallanti, MD; PhD (1)
PMID 20402591, PMID 21998287, PMID 22240407, PMID 35067599, PMID 38124508, PMID 39946129, PMID 40902161