60 completed. 60 Phase 3, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 60 | Completed 60 |
| Phase 2 | 10 | Completed 10 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients Cuff Leak Test, Dexamethasone 4mg - Respiratory Failure | Phase 3 | Completed | St. Joseph's Healthcare Hamilton | 100 | 2023-04-05 | 2025-03-10 |
| Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age Remifentanil Hydrochloride, Pupillometry measurement - Opioid Toxicity, Pupillary Miosis | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 10 | 2022-10-01 | 2025-05-02 |
| Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Norepinephrine, Lactated Ringers, Intravenous, normal saline - Respiratory Failure, Hypotension and Shock | Phase 3 | Completed | Wright State University | 42 | 2022-08-09 | 2024-07-15 |
| Non-invasive Ventilation and Dex in Critically Ill Adults Dexmedetomidine, Placebo - Respiratory Insufficiency | Phase 3 | Completed | St. Joseph's Healthcare Hamilton | 24 | 2022-03-07 | 2024-10-28 |
| Randomized Open Investigation Determining Steroid Dose Weight-based dexamethasone dose - Covid19 | Phase 3 | Completed | Northwell Health | 142 | 2021-03-19 | 2023-07-20 |
| Nebulised Heparin in Patients With Severe COVID-19 Nebulised unfractionated heparin (UFH) - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Completed | Australian National University | 57 | 2020-11-01 | 2025-11-05 |
| Reduced Anticoagulation Targets in ECLS (RATE) Heparin, LMWH - Heart Failure, Respiratory Failure | Phase 3 | Completed | University Medical Center Groningen | 330 | 2020-10-01 | 2025-05-02 |
| Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia Almitrine, Placebo - Covid 19, Hypoxemic Respiratory Failure | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 181 | 2020-09-03 | 2022-05-03 |
| Enoxaparin at Prophylactic or Therapeutic Doses in COVID-19 Enoxaparin - Covid19, Thrombosis | Phase 3 | Completed | ASST Fatebenefratelli Sacco | 142 | 2020-07-27 | 2023-07-25 |
| A Multicentre Open-label Two-arm Randomised Superiority Clinical Trial of Azithromycin Versus Usual Care In Ambulatory COVID19 (ATOMIC2) Azithromycin Capsule - COVID-19 | Phase 3 | Completed | University of Oxford | 298 | 2020-06-03 | 2021-05-06 |
| Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19 Tigerase® and best available care, Best available care - COVID-19, Coronavirus Disease 2019 | Phase 3 | Completed | AO GENERIUM | 100 | 2020-06-01 | 2020-10-14 |
| Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure Aviptadil by intravenous infusion + standard of care, Normal Saline Infusion + standard of care - Critical COVID-19 With Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS) | Phase 2 / Phase 3 | Completed | APR Applied Pharma Research s.a. | 203 | 2020-05-15 | 2023-07-24 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Diaphragmatic Paralysis Comparison Between Local Anesthetic Volumen Doses After Interscalene Block Interscalene brachial plexus block, Levobupivacaine Hydrochloride 2.5 MG/ML - Diaphragmatic Paralysis, Brachial Plexus Block | Phase 3 | Completed | Instituto de Investigación Sanitaria Aragón | 48 | 2020-02-11 | 2022-08-12 |
| Interscalene Block and Dysfunction Diaphragmatic Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.1% Injectable Solution - Diaphragmatic Paralysis | Phase 3 | Completed | University Hospital, Lille | 60 | 2019-10-29 | 2026-06-11 |
| Demonstration of Equivalence and Early Onset of a Novel Anti-allergic Nasal Spray Compared to Marketed Nasal Spray Rhinocort, Budesolv, Placebo - Allergic Rhinitis, Allergic Conjunctivitis | Phase 3 | Completed | Marinomed Biotech AG | 82 | 2018-11-19 | 2020-10-12 |
| A Study to Compare Two Formulations of Xylometazoline/Dexpanthenol Nasal Spray for the Treatment of Nasal Congestion. xylo+dex nasal spray (0.1 mg+5 mg/dose), Nasic - Nasal Congestion | Phase 3 | Completed | McNeil AB | 140 | 2018-02-26 | 2018-10-18 |
| Efficacy and Safety of Pediatric Drugs in Nasal Congestion Naridrin, Afrin - Nasal Congestion | Phase 3 | Completed | EMS | 292 | 2018-01-16 | 2019-10-16 |
| Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine - Anesthesia, General Anesthesia | Phase 3 | Completed | University of Saskatchewan | 50 | 2017-10-15 | 2021-08-10 |
| Self-management of Sedative Therapy by Ventilated Patients Dexmedetomidine - Critical Illness, Anxiety | Phase 2 / Phase 3 | Completed | Mayo Clinic | 161 | 2016-11-01 | 2025-10-02 |
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Nasal Obstruction (15) · COVID-19 (7) · Pulmonary Disease, Chronic Obstructive (5) · Common Cold (4) · Heart Failure (4) · Pharyngitis (4) · Respiratory Aspiration (4) · Respiratory Distress Syndrome (4) · Rhinitis, Allergic, Seasonal (4) · Rhinorrhea (4) · Sneezing (4) · Coronavirus Infections (3) · Cough (3) · Fatigue (3)
Respiration Disorders (60) · Respiratory Tract Diseases (59) · Pathological Conditions, Signs and Symptoms (30) · Infections (21) · Lung Diseases (19) · Pathologic Processes (19) · Otorhinolaryngologic Diseases (16) · Respiratory Tract Infections (16) · Airway Obstruction (15) · Nose Diseases (15) · RNA Virus Infections (14) · Virus Diseases (14) · Signs and Symptoms (13) · Pneumonia (10)
Dexmedetomidine (3) · Acetaminophen (2) · Azithromycin (2) · Dexamethasone (2) · Enoxaparin (2) · Fentanyl (2) · Standard of Care (2) · bilastine (2) · favipiravir (2) · Acetazolamide (1) · Acetylcysteine (1) · Almitrine (1) · Aspirin (1) · Budesonide (1) · Cetirizine (1)
Assistance Publique - Hôpitaux de Paris (3) · Ache Laboratorios Farmaceuticos S.A. (2) · Faes Farma, S.A. (2) · MDVI, LLC (2) · McMaster University (2) · Patrick Murphy (2) · St. Joseph's Healthcare Hamilton (2) · UPECLIN HC FM Botucatu Unesp (2) · United Christian Hospital (2) · University of Turin, Italy (2) · AO GENERIUM (1) · APR Applied Pharma Research s.a. (1) · ASST Fatebenefratelli Sacco (1) · Australian National University (1) · Bayer (1)
United States (21) · Canada (11) · United Kingdom (9) · Brazil (7) · France (7) · Australia (6) · Italy (6) · Netherlands (5) · Russia (5) · Spain (5) · Austria (4) · Belgium (4) · Germany (4) · Puerto Rico (4) · Argentina (3)
Carol Epstein, MD (2) · Jose R Fioretto, MD, PhD (2) · V. M. Ranieri, MD (2) · Aaron Chiu, MD (1) · Alfonso Solimano, MD (1) · Alison Hughes (1) · Armand Mekonto Dessap, MD (1) · Avroy A. Fanaroff, MD (1) · Babak Saaedi (1) · Barbara J. Stoll, MD (1) · Barbara Schmidt, MD (1)
PMID 35639525, PMID 10400143, PMID 10545589, PMID 16651303, PMID 17764785, PMID 18245420, PMID 18714060, PMID 18989547, PMID 19132976, PMID 20302428, PMID 20407057, PMID 20562702, PMID 21403073, PMID 21983627, PMID 22077106, PMID 22580593, PMID 22997204, PMID 23644995, PMID 23944299, PMID 23985625, PMID 24652410, PMID 24973289, PMID 24983742, PMID 26158245, PMID 26162889, PMID 28118549, PMID 28286047, PMID 28528348, PMID 28606907, PMID 29275926, PMID 29866165, PMID 30145946, PMID 31012225, PMID 31120585, PMID 31352795, PMID 31577692, PMID 31910992, PMID 31975354, PMID 32586587, PMID 32657973, PMID 32740181, PMID 33874993, PMID 33932465, PMID 34252378, PMID 34428130, PMID 34755519, PMID 35389229, PMID 35578271, PMID 36044317, PMID 36157895
2005 (2), 2019 (2), 2014 (1), 2018 (1), M01RR000070 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR008084 (1), R01HL130881 (1), U01HD019897 (1), U01HL107681 (1), U10HD021364 (1), U10HD021373 (1), U10HD021385 (1)