22 completed, 18 unknown, 7 recruiting, 6 terminated. 28 Not applicable, 11 Phase 2, 5 Phase 3, 3 Phase 1, 3 Phase 4.
Follow Refractory Epilepsy: new trials by email Literature Review of Refractory Epilepsy trials Research Report on Refractory Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Characterisation of Laryngeal Evoked Potentials Induced by Vagus Nerve Stimulation in Refractory Epilepsy Patients Increasing VNS Intensities Induced with Magnet - Refractory Epilepsy, Epilepsy | Not applicable | Not yet recruiting | Université Catholique de Louvain | 110 | 2027-01-01 | 2026-10-29 |
| Post-Market Real-World Evidence Registry for the NeuroOne OneRF® Ablation System for Epilepsy Participants are not assigned an intervention as part of the study. - Drug Resistant Epilepsy, Refractory Epilepsy | Recruiting | NeuroOne Medical Technologies Corporation | 100 | 2026-09-18 | 2026-10-16 | |
| Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG SEEG recordings and SPES - Refractory Epilepsy, Neuromodulation | Not applicable | Not yet recruiting | Xuanwu Hospital, Beijing | 10 | 2025-12-08 | 2025-12-26 |
| Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application Experimental Intervention (Music A), Active Comparator Intervention (Music B), Active Comparator Intervention (Music C) - Epilepsy, Refractory Epilepsy | Not applicable | Recruiting | Dartmouth-Hitchcock Medical Center | 24 | 2025-07-22 | 2026-05-20 |
| Cannabidiol as add-on Therapy for Children With Refractory Epilepsy (CBD-uN1que), a High-quality Individualized Approach: a Series of N-of-1 Trials Cannabidiol (CBD) oral solution, Placebo - Refractory Epilepsy in Children, Refractory Epilepsy | Phase 3 | Recruiting | UMC Utrecht | 50 | 2025-02-06 | 2026-06-25 |
| Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG SEEG recordings and SPES - Refractory Epilepsy, Sleep | Not applicable | Recruiting | Xuanwu Hospital, Beijing | 20 | 2024-07-08 | 2025-06-27 |
| Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEG Direct Electrical Stimulation - Refractory Epilepsy, Consciousness, Loss of | Not applicable | Completed | Xuanwu Hospital, Beijing | 8 | 2024-05-27 | 2025-07-11 |
| Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy Leucine-Enriched Essential Amino Acid powder - Refractory Epilepsy, Drug Resistant Epilepsy | Phase 1 | Completed | Elizabeth Anne Thiele | 4 | 2024-05-10 | 2026-05-22 |
| High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy Active Comparator: Unilateral real High definition transcranial direct current stimulation, Active Comparator: Bilateral real High definition transcranial direct current stimulation, Sham Comparator: Sham High definition transcranial direct current stimulation - Transcranial Direct Current Stimulation, EEG | Not applicable | Unknown | Anhui Medical University | 90 | 2024-02-12 | 2024-02-20 |
| An Automated Navigation System for Deep Brain Electrode Implantation Advanced Parkinson's Disease, Refractory Epilepsy | Unknown | Beijing Tiantan Hospital | 30 | 2024-01-01 | 2024-05-02 | |
| Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration, transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration - Refractory Epilepsy | Not applicable | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 34 | 2023-07-01 | 2025-09-10 |
| Optimal Stimulation Parameters to Disrupt Epileptiform Activity Neurostimulation - Refractory Epilepsy | Not applicable | Completed | Massachusetts General Hospital | 16 | 2023-06-13 | 2026-09-02 |
| Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Trial Exploring Epileptic and Non-epileptic Outcomes Fenfluramine - Refractory Epilepsy, SYNGAP1 Encephalopathy | Phase 4 | Completed | Hospital Ruber Internacional | 20 | 2022-10-20 | 2026-09-29 |
| A Study to Evaluate fMRI of Active DBS Stimulation in Epilepsy Functional magnetic resonance imaging (fMRI) - Refractory Epilepsy | Not applicable | Withdrawn | Mayo Clinic | 2022-09-01 | 2022-11-01 | |
| The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy Ketamine Hydrochloride - Drug Resistant Epilepsy, Medically Refractory Epilepsy | Phase 2 | Completed | Madeline Fields | 12 | 2022-08-26 | 2026-09-11 |
| Modulation of Emotion Perception in Humans Via Amygdala Stimulation Electrical Stimulation - Refractory Epilepsy | Not applicable | Completed | Dartmouth-Hitchcock Medical Center | 16 | 2022-03-31 | 2025-09-22 |
| Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy STARSTIM device, Sham Device - Refractory Epilepsy, Focal Seizure | Not applicable | Completed | Neuroelectrics Corporation | 127 | 2021-10-25 | 2026-04-08 |
| Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization - Refractory Epilepsy, Deep Brain Stimulation | Early Phase 1 | Recruiting | University of Minnesota | 30 | 2021-07-01 | 2026-10-16 |
| Exercise as Adjunctive Treatment for Refractory Epilepsy Exercise program, Health Coach, Health Information - Refractory Epilepsy, Epilepsy | Not applicable | Terminated | Wake Forest University Health Sciences | 10 | 2021-04-13 | 2022-12-07 |
| Localization of the Reward Positivity to ACC Virtual T-maze task - Refractory Epilepsy | Not applicable | Unknown | University Hospital, Ghent | 40 | 2021-03-04 | 2024-01-05 |
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Drug Resistant Epilepsy (59) · Epilepsy (13) · Seizures (4) · Epilepsies, Partial (3) · Arrhythmias, Cardiac (1) · Brain Diseases (1) · Chromosome 15q, tetrasomy (1) · Death, Sudden (1) · Epilepsy, Tonic-Clonic (1) · Epileptic Encephalopathy, Early Infantile, 4 (1) · Focal Cortical Dysplasia (1) · Genetic Diseases, Inborn (1) · Hypersensitivity (1) · Learning Disabilities (1) · Mental Disorders (1)
Central Nervous System Diseases (59) · Brain Diseases (58) · Nervous System Diseases (58) · Epilepsy (46) · Pathological Conditions, Signs and Symptoms (8) · Neurologic Manifestations (6) · Signs and Symptoms (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Mental Disorders (2) · Neurobehavioral Manifestations (2) · Pathologic Processes (2) · Anxiety Disorders (1) · Behavior (1) · Cardiovascular Diseases (1) · Communication Disorders (1)
Transcranial Direct Current Stimulation (3) · Cannabidiol (2) · Diet, Ketogenic (2) · Ketamine (2) · perampanel (2) · Adrenal Cortex Hormones (1) · Anticonvulsants (1) · Barbiturates (1) · Benzodiazepines (1) · Clobazam (1) · Control Groups (1) · Diazepam (1) · Electric Stimulation (1) · Evoked Potentials (1) · Exercise (1)
Beijing Pins Medical Co., Ltd (3) · University Hospital, Ghent (3) · Xuanwu Hospital, Beijing (3) · Dartmouth-Hitchcock Medical Center (2) · Hospital Ruber Internacional (2) · Lady Hardinge Medical College (2) · Neuroelectrics Corporation (2) · Acorda Therapeutics (1) · All India Institute of Medical Sciences (1) · American University (1) · Anhui Medical University (1) · Assistance Publique Hopitaux De Marseille (1) · Assiut University (1) · Azienda Usl di Bologna (1) · Beijing Tiantan Hospital (1)
United States (17) · China (8) · France (7) · Spain (6) · Belgium (5) · Italy (4) · Germany (3) · India (3) · Netherlands (3) · United Kingdom (3) · Austria (2) · Canada (2) · Denmark (2) · Hungary (2) · Poland (2)
Liankun Ren (2) · Satinder Aneja, MD (2) · Alfred Meurs, MD PhD (1) · Andreas Schulze Bonhage, MD (1) · Angel Aledo-Serrano, MD, PhD (1) · Antonio Gil-Nagel, MD, PHD (1) · Baomin Li (1) · Brian C Fidali, MD (1) · Carla Bente, MD (1) · Catherine Chu, MD (1) · Daniel San-juan, MD (1) · Dorota Antczak-Marach, M.D. (1) · Elinor Ben-Menachem, MD,PhD (1) · Elizabeth Thiele, MD, PhD (1)
PMID 16499758, PMID 21167786, PMID 22399764, PMID 22709423, PMID 23223279, PMID 24370818, PMID 25741734, PMID 27693237, PMID 27915117, PMID 29373639, PMID 30232735, PMID 30642370, PMID 32190059, PMID 32471438, PMID 32588435, PMID 34389161, PMID 34862297, PMID 34870321, PMID 35132096, PMID 35833911, PMID 36867910, PMID 36927882, PMID 42401244
2023 (1), R01NS119483 (1), R21MH124674 (1)