3 completed, 3 recruiting, 2 unknown, 1 active not recruiting. 4 Phase 1, 4 Phase 2, 3 Not applicable.
Follow Focal Cortical Dysplasia: new trials by email Literature Review of Focal Cortical Dysplasia trials Research Report on Focal Cortical Dysplasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fluorescence Guided Focal Cortical Dysplasia Surgery 5-ALA (Gliolan) - Drug Resistant Epilepsy | Phase 2 | Not yet recruiting | Hospices Civils de Lyon | 5 | 2026-09-01 | 2026-06-18 |
| Safety, Tolerability, and Pharmacokinetics of SVG103 (Paxalisib) in Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC) or Hemimegalencephaly (HME) SVG103 - Focal Cortical Dysplasia, Tuberous Sclerosis Complex (TSC) | Phase 1 / Phase 2 | Recruiting | Sovargen | 12 | 2026-07-14 | 2026-08-10 |
| Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs. Radiprodil + co-administered drugs - Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia | Phase 1 | Completed | GRIN Therapeutics, Inc. | 18 | 2025-05-20 | 2025-11-18 |
| Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults Radiprodil with Carbamazepine, Radiprodil with Itraconazole - Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia | Phase 1 | Terminated | GRIN Therapeutics, Inc. | 30 | 2025-05-08 | 2025-11-21 |
| Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II Radiprodil - Tuberous Sclerosis Complex, Focal Cortical Dysplasia | Phase 1 / Phase 2 | Active not recruiting | GRIN Therapeutics, Inc. | 30 | 2024-07-10 | 2026-04-01 |
| First-in-human Experience Using Novel Ultraflexible Low-impedance Electrode Arrays: an IDEAL Stage 1 Study Insertion of electrode during planned neurosurgery for epilepsy - Epilepsy, Focal Cortical Dysplasia | Not applicable | Unknown | Great Ormond Street Hospital for Children NHS Foundation Trust | 6 | 2024-02-01 | 2023-11-03 |
| Mos-FED (Mosaicism in Focal Epilepsy Cortical Dysplasia Tissue) Blood and nasal swab sampling - Focal Cortical Dysplasia, Epilepsy | Not applicable | Recruiting | King's College Hospital NHS Trust | 60 | 2023-04-09 | 2024-10-23 |
| Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery Intra-operative brain tonometry - Epilepsy, Focal Cortical Dysplasia | Not applicable | Withdrawn | University of California, Los Angeles | 2018-07-16 | 2023-10-10 | |
| Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia visual and quantitative SEEG signal analysis, Resective epilepsy surgery procedure - Refractory Epilepsy, Focal Epilepsy | Unknown | University Hospital, Strasbourg, France | 240 | 2018-01-15 | 2019-06-24 | |
| Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies Sampling of blood, frozen resected tissues, and cerebrospinal fluid (CSF) - Drug-resistant Focal Epilepsies in Pediatric Population | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 450 | 2015-12-17 | 2026-04-17 | |
| A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD Everolimus - Epilepsy, Tuberous Sclerosis Complex | Phase 2 | Completed | NYU Langone Health | 15 | 2014-01-01 | 2021-09-01 |
| Determining the Extent of Diffusion Tensor Abnormalities in Focal Cortical Dysplasia Magnetoencephalography, MR imaging, Diffusion Tensor Imaging - Focal Cortical Dysplasia, Epilepsy | Completed | The Hospital for Sick Children | 12 | 2007-05-01 | 2013-09-05 |
Tuberous Sclerosis (7) · Epilepsy (6) · Hemimegalencephaly (3) · Drug Resistant Epilepsy (2) · Encephalitis (2) · Epilepsies, Partial (2) · Brain Neoplasms (1) · Gliosis (1) · Hypothalamic hamartomas (1) · Polymicrogyria (1) · Stroke (1) · Sturge-Weber Syndrome (1)
Congenital Abnormalities (12) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (12) · Malformations of Cortical Development (12) · Malformations of Cortical Development, Group I (12) · Nervous System Diseases (12) · Nervous System Malformations (12) · Brain Diseases (8) · Central Nervous System Diseases (8) · Genetic Diseases, Inborn (7) · Hamartoma (7) · Heredodegenerative Disorders, Nervous System (7) · Neoplasms (7) · Neoplasms, Multiple Primary (7) · Neoplastic Syndromes, Hereditary (7) · Neurocutaneous Syndromes (7)
radiprodil (3) · Blood Specimen Collection (1) · Carbamazepine (1) · Diffusion Tensor Imaging (1) · Everolimus (1) · Itraconazole (1) · Magnetic Resonance Spectroscopy (1) · Magnetoencephalography (1)
GRIN Therapeutics, Inc. (3) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Hospices Civils de Lyon (1) · King's College Hospital NHS Trust (1) · NYU Langone Health (1) · Sovargen (1) · The Hospital for Sick Children (1) · University Hospital, Strasbourg, France (1) · University of California, Los Angeles (1)
Australia (4) · Canada (3) · France (3) · United Kingdom (3) · United States (2) · Belgium (1) · Italy (1) · Netherlands (1) · Poland (1) · Spain (1)
Aria Fallah, MD (1) · Charles Raybaud, M.D. (1) · Martin Tisdall, MD FRCS (1) · Orrin Devinsky, MD (1) · Russell Chin (1)
PMID 31444548, PMID 33407896, PMID 33434304, PMID 33834539, PMID 35587487, PMID 36307217, PMID 37324239, PMID 38710875, PMID 39460693, PMID 40307383
2023 (1), 2025 (1)