6 completed, 2 terminated, 2 unknown, 1 withdrawn. 11 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 6, Terminated 2, Unknown 2, Withdrawn 1 |
| Phase 3 | 3 | Completed 2, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow Refractory Epilepsy: new trials by email Literature Review of Refractory Epilepsy trials Research Report on Refractory Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy Ketamine Hydrochloride - Drug Resistant Epilepsy, Medically Refractory Epilepsy | Phase 2 | Completed | Madeline Fields | 12 | 2022-08-26 | 2026-09-11 |
| Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC), Placebo delivery via an implantable pump and a cranial port and dual lumen catheter (CIC) - Refractory Epilepsy | Phase 2 | Terminated | Cerebral Therapeutics LLC | 30 | 2020-08-21 | 2024-03-13 |
| Voronistat in Pediatric Patients With Drug Resistant Epilepsy Vorinostat 100 MG - Refractory Epilepsy | Phase 2 | Unknown | University of Calgary | 12 | 2018-12-10 | 2019-03-29 |
| Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus Traditional Treatment (Group T), Ketamine Infusion (Group K) - Refractory Epilepsy | Phase 2 / Phase 3 | Withdrawn | University of Alabama at Birmingham | 2017-05-04 | 2021-05-21 | |
| Effect of Outpatient Classic Ketogenic Diet in Epileptic Children and Adolescent. ketogenic diet - Refractory Epilepsy | Phase 2 | Unknown | Tehran University of Medical Sciences | 30 | 2016-07-01 | 2017-01-25 |
| Bioavailability, Safety and Tolerability of Diazepam Nasal Spray Versus Diazepam Rectal Gel (Diastat®) diazepam nasal spray, diazepam rectal gel - Refractory Epilepsy | Phase 2 | Terminated | Acorda Therapeutics | 78 | 2015-06-01 | 2018-10-16 |
| Evaluation of the Modified Atkins Diet in Young Children With Refractory Epilepsy Modified Atkin Diet - Refractory Epilepsy | Phase 2 / Phase 3 | Completed | Lady Hardinge Medical College | 31 | 2012-11-01 | 2019-01-15 |
| Efficacy of a Simplified Modified Atkins Diet in Children With Refractory Epilepsy Simplified Modified Atkins Diet, Antiepileptic drugs alone - Refractory Epilepsy | Phase 2 / Phase 3 | Completed | Lady Hardinge Medical College | 81 | 2012-09-01 | 2019-01-15 |
| A Controlled Clinical Trial of Cathodal Transcranial Direct Current Stimulation in Patients With Refractory Epilepsy Nicolet Endeavor CR: 30min, Nicolet Endeavor CR: 60min, Nicolet Endeavor CR: 30min for 3 days - Refractory Epilepsy | Phase 2 | Completed | El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez | 28 | 2012-02-01 | 2015-04-07 |
| Thalidomide Low Threshold in Epilepsy 3-phthalimidoglutarimide (Thalidomide) - Refractory Epilepsy | Phase 1 / Phase 2 | Completed | National Institute of Neurology and Neurosurgery, Mexico | 7 | 2006-06-01 | 2010-02-18 |
| Safety and Efficacy of 333369 in the Treatment of Partial Epilepsy RWJ-333369 - Refractory Epilepsy | Phase 2 | Completed | SK Life Science, Inc. | 2005-02-01 | 2012-08-02 |
Drug Resistant Epilepsy (11) · Seizures (3) · Epilepsy (2)
Brain Diseases (11) · Central Nervous System Diseases (11) · Nervous System Diseases (11) · Epilepsy (9) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3)
Ketamine (2) · Anticonvulsants (1) · Barbiturates (1) · Benzodiazepines (1) · Diazepam (1) · Diet, Ketogenic (1) · Propofol (1) · S-2-O-carbamoyl-1-o-chlorophenyl-ethanol (1) · Sensitivity Training Groups (1) · Thalidomide (1) · Transcranial Direct Current Stimulation (1) · Vorinostat (1)
Lady Hardinge Medical College (2) · Acorda Therapeutics (1) · Cerebral Therapeutics LLC (1) · El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez (1) · Madeline Fields (1) · National Institute of Neurology and Neurosurgery, Mexico (1) · SK Life Science, Inc. (1) · Tehran University of Medical Sciences (1) · University of Alabama at Birmingham (1) · University of Calgary (1)
United States (4) · India (2) · Argentina (1) · Australia (1) · Canada (1) · Hungary (1) · Iran (1) · Israel (1) · Mexico (1) · Netherlands (1) · Poland (1) · Russia (1) · Spain (1) · United Kingdom (1)
Satinder Aneja, MD (2) · Daniel San-juan, MD (1) · Jong Rho, MD (1) · Julio Sotelo, MD (1) · Lara Marcuse, MD (1) · Lee Min Jae (1) · Madeline Fields, MD (1) · Maryam Mahmoudi, MD, PHD (1) · Vinodkumar Singh, MD (1)
PMID 16499758, PMID 21167786, PMID 27693237, PMID 29373639, PMID 30232735, PMID 32588435, PMID 34389161, PMID 34870321