36 completed, 18 unknown, 8 recruiting, 7 not yet recruiting. 53 Not applicable, 6 Phase 4, 5 Phase 2, 3 Early Phase 1, 3 Phase 3.
Follow Pulpitis - Irreversible: new trials by email Literature Review of Pulpitis - Irreversible trials Research Report on Pulpitis - Irreversible
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Observational Cross-sectional Study Aiming to Determine the Correlation Between Pulpal Status and IL-8 and Presepsin Levels in the Pulpal Blood. IL-8 and Presepsin levels in the pulpal blood. - Pulpitis - Irreversible, Pulpitis - Reversible | Not yet recruiting | Cairo University | 50 | 2026-11-01 | 2026-03-12 | |
| Clinical and Radiographic Assessment of Bio C Repair, Biodentine and Mineral Trioxide Aggregate Biodentine, Bio C repair - Pulpitis - Irreversible | Not applicable | Not yet recruiting | Cairo University | 60 | 2026-04-20 | 2026-04-13 |
| SCN9A Gene Expression and Inflammatory Cytokines Inferior Alveolar Nerve Block - Pulpitis - Irreversible | Completed | Jamia Millia Islamia | 144 | 2026-04-10 | 2026-11-02 | |
| Comparison of the Efficacy of Inferior Alveolar Nerve Block and Digital Anesthesia in Pulpectomy of Mandibular Permanent Molars in Children Computer-Controlled Digital Anesthesia, Inferior Alveolar Nerve Block - Pulpitis - Irreversible, Pulpitis - Reversible | Not applicable | Recruiting | Inonu University | 128 | 2026-04-01 | 2026-06-09 |
| Effect of Cryotherapy on Postoperative Pain for Pulpotomy Cryotherapy - Pulpitis - Irreversible | Early Phase 1 | Active not recruiting | Sirawut Hiran-us | 82 | 2026-01-21 | 2026-02-02 |
| The Role of the Pre-operative Condition and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full Pulpotomy in Symptomatic Permanent Mature Molars Conventional root canal treatment, Full pulpotomy - Pulpitis - Irreversible | Not applicable | Recruiting | Misr International University | 58 | 2026-01-17 | 2026-01-21 |
| Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples Pulpitis, Pulpitis - Irreversible | Not yet recruiting | Kırıkkale University | 70 | 2025-12-01 | 2025-12-01 | |
| Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp Pulpotomy, Pulpectomy - Pulp Therapy, Pulpitis - Irreversible | Not applicable | Not yet recruiting | Ajman University | 30 | 2025-12-01 | 2025-11-17 |
| Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis Total Pulpotomy, Radicular pulpotomy, Root canal treatment - Post-operative Pain, Pulpitis - Irreversible | Not applicable | Recruiting | Mustafa Kemal University | 99 | 2025-12-01 | 2026-06-05 |
| Clinical and Radiographic Evaluation of E-IodoCal in Primary Molar Pulpectomy E-IodoCal Root Canal Obturation (Group I), Zinc Oxide-Eugenol Root Canal Obturation (Group II) - Pulpectomy, Pulpitis - Irreversible | Not applicable | Recruiting | Tanta University | 30 | 2025-11-25 | 2026-10-22 |
| Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France Pulpitis - Irreversible, Pulp Necrosis | Recruiting | University Hospital, Strasbourg, France | 100 | 2025-11-07 | 2026-03-03 | |
| Effect of Vitamin D on Postoperative Pain in Symptomatic Irreversible Pulpitis Vitamin D3, Placebo - Pulpitis - Irreversible, Vitamin D Deficiency | Not applicable | Active not recruiting | Future University in Egypt | 54 | 2025-11-01 | 2026-05-12 |
| Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars Lesion sterilization and tissue repair, Conventional pulpectomy - Pulpitis - Irreversible, Pulp Necroses | Active not recruiting | Çanakkale Onsekiz Mart University | 59 | 2025-10-01 | 2026-10-07 | |
| Effect of Menstrual Phase on the Anesthetic Efficacy Inferior Alveolar Nerve Block - Pulpitis - Irreversible | Not applicable | Recruiting | Jamia Millia Islamia | 150 | 2025-09-11 | 2026-10-30 |
| Single vs Multiple Visit RCT;Endodontic Flare up. single visit root canal treatment, Multiple visit root canal treatment - Postoperative Complication, Root Canal Therapy | Not applicable | Completed | College of Physicians and Surgeons Pakistan | 344 | 2025-09-05 | 2026-11-12 |
| Can Pretreatment With Analgesics Reduce Postendodontic Pain? Pre treatment with NSAIDS, No pretreatment with NSAIDS. - Pulpitis - Irreversible | Not applicable | Completed | College of Physicians and Surgeons Pakistan | 160 | 2025-08-01 | 2025-12-09 |
| Effect of Probiotics, Double Antibiotic Paste, and Calcium Hydroxide on Postoperative Pain in Irreversible Pulpitis: A Randomized Trial Probiotic - Root Canal Treatment, Irreversible Pulpitis With Apical Periodontitis | Not applicable | Completed | Dow University of Health Sciences | 75 | 2025-06-01 | 2025-12-08 |
| Single Gene Polymorphism and the Success Rate of Inferior Alveolar Nerve Block Inferior Alveolar Nerve Block, Inferior-Alveolar-Nerve-Block - Pulpitis - Irreversible | Not applicable | Completed | Jamia Millia Islamia | 320 | 2025-05-10 | 2026-03-19 |
| The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy Biodentine - Pulp Exposure, Dental, Pulp Disease, Dental | Active not recruiting | Ataturk University | 96 | 2025-05-02 | 2025-11-18 | |
| Outcome of Pulpotomy With MTA and Biodentin in Permanent Teeth With Caries Exposure Pulp Therapy with Mineral trioxide aggregate (MTA), Pulp Therapy with Biodentine - Pulpitis - Irreversible | Not applicable | Not yet recruiting | Altamash Institute of Dental Medicine | 136 | 2025-05-02 | 2025-04-24 |
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Pain, Postoperative (12) · Pulpitis (8) · Dental Pulp Necrosis (5) · Dental Pulp Diseases (4) · Periapical Periodontitis (3) · Dental Caries (2) · Pain (2) · Agnosia (1) · Dental Pulp Exposure (1) · Head and Neck Neoplasms (1) · Hypersensitivity (1) · Inflammation (1) · Postoperative Complications (1) · Root Resorption (1) · Tooth Mobility (1)
Pathological Conditions, Signs and Symptoms (21) · Stomatognathic Diseases (20) · Pathologic Processes (18) · Tooth Diseases (18) · Neurologic Manifestations (15) · Signs and Symptoms (15) · Pain (12) · Postoperative Complications (12) · Dental Pulp Diseases (11) · Necrosis (5) · Mouth Diseases (4) · Periodontal Diseases (4) · Jaw Diseases (3) · Periapical Diseases (3) · Periodontitis (3)
Pulpotomy (6) · Cryotherapy (5) · tricalcium silicate (5) · Pemetrexed (4) · Dexamethasone (3) · Diclofenac (3) · Wound Healing (3) · mineral trioxide aggregate (3) · Calcium Hydroxide (2) · Carticaine (2) · Lidocaine (2) · Pulpectomy (2) · Anti-Inflammatory Agents, Non-Steroidal (1) · Cholecalciferol (1) · Crowns (1)
Cairo University (15) · Jamia Millia Islamia (6) · Cukurova University (5) · Ain Shams University (4) · Postgraduate Institute of Dental Sciences Rohtak (3) · College of Physicians and Surgeons Pakistan (2) · Future University in Egypt (2) · Inonu University (2) · Misr International University (2) · Mustafa Kemal University (2) · Tanta University (2) · Abramson Cancer Center at Penn Medicine (1) · Ajman University (1) · Altamash Institute of Dental Medicine (1) · Armed Forces Institute of Dentistry, Pakistan (1)
Egypt (18) · Turkey (Türkiye) (14) · India (10) · Pakistan (7) · Brazil (1) · France (1) · Hong Kong (1) · Jordan (1) · Malaysia (1) · Mexico (1) · Singapore (1) · Spain (1) · Thailand (1) · United Kingdom (1) · United States (1)
Ahmed A Ghobashy, Prof. Dr. (1) · Ahmed M Ghobashy, Prof. Dr. (1) · Amatallah H Al-Rawhani, Pos (1) · Amatallah H Al-Rawhani, Postgraduate (1) · Angie G Ghoneim (1) · Angie G Ghoneim, Professor (1) · Ayca Yilmaz, Assoc. Prof. (1) · Basma G Awad, PHD (1)
PMID 11132515, PMID 20212137, PMID 22892729, PMID 23232607, PMID 26838149, PMID 27274150, PMID 27696017, PMID 30664240, PMID 31277893, PMID 32266988, PMID 32950193, PMID 33384483, PMID 35034465, PMID 35080024, PMID 35226769, PMID 36574828, PMID 37209243, PMID 38987018, PMID 39266985, PMID 39325552, PMID 39352296, PMID 39909197, PMID 40898413, PMID 41291644, PMID 9522755