32 recruiting, 25 not yet recruiting, 15 completed, 9 active not recruiting. 55 Not applicable, 11 Phase 2, 3 Phase 3, 2 Phase 1, 1 Early Phase 1.
Follow PTSD - Post Traumatic Stress Disorder: new trials by email Literature Review of PTSD - Post Traumatic Stress Disorder trials Research Report on PTSD - Post Traumatic Stress Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSD Written Exposure Therapy (WET), methylphenidate (MPH), placebo (PBO) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | VA Office of Research and Development | 138 | 2027-07-01 | 2026-10-29 |
| Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation - PTSD - Post Traumatic Stress Disorder | Early Phase 1 | Not yet recruiting | Wayne State University | 60 | 2027-04-01 | 2026-07-13 |
| Medical Nitrous Oxide Combined With Personalized Traumatic Script Exposure for the Treatment of Post-Traumatic Stress Disorder MEOPA (Nitrous Oxide/Oxygen Premix), Medical Air in Oxygen, Personalized Traumatic Script Exposure - PTSD - Post Traumatic Stress Disorder | Phase 3 | Not yet recruiting | University Hospital, Tours | 96 | 2027-01-01 | 2026-11-10 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback - PTSD, PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University of New Mexico | 150 | 2026-12-31 | 2026-10-30 |
| Deaf CBT-TS to Reduce Suicide Risk Deaf CBT-TS - Depression - Major Depressive Disorder, Anxiety | Not applicable | Not yet recruiting | University of Rochester | 110 | 2026-12-01 | 2026-11-04 |
| Adaptation of the STAIR-NT for First Responders Adapted STAIR-NT - PTSD - Post Traumatic Stress Disorder, TBI-Traumatic Brain Injury | Not applicable | Not yet recruiting | Florida State University | 80 | 2026-11-01 | 2026-08-25 |
| ONE-P TMS Military Veterans D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-20 |
| ONE-P TMS First Responders D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-19 |
| Feasibility of a Web-based Single-session Intervention Combined With Ecological Momentary Assessment and Intervention for Patients With Complex Posttraumatic Stress Disorder Awaiting Inpatient Treatment Digital self-administered web-based single-session intervention, While Waiting application: Ecological momentary assessments and interventions - PTSD - Post Traumatic Stress Disorder, Depression | Not applicable | Not yet recruiting | University of Oslo | 30 | 2026-10-09 | 2026-11-05 |
| Virtual Reality Assisted Trauma Focused CBT VR Photoscan, Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) - PTSD - Post Traumatic Stress Disorder | Not applicable | Recruiting | Queen's University, Belfast | 40 | 2026-10-05 | 2026-11-03 |
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder COMP360 psilocybin - PTSD - Post Traumatic Stress Disorder, PTSD | Phase 2 / Phase 3 | Recruiting | COMPASS Pathways | 300 | 2026-09-14 | 2026-11-05 |
| Dexmedetomidine Combined With Transcutaneous Vagus Nerve Stimulation (taVNS) Can Reduce the Incidence of PTSD in Trauma Patients After Surgery Dexmedetomidine 0.1μg/kg/h, tavns - PTSD - Post Traumatic Stress Disorder, taVNS | Not applicable | Recruiting | Affiliated Hospital of Nantong University | 300 | 2026-09-12 | 2026-09-17 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Self-Compassion, Health, and Empowerment The Self-Compassion, Health, and Empowerment (SHE) Intervention, Health and Nutrition Program - Intimate Partner Violence (IPV), Depression and/or Anxiety Symptoms | Not applicable | Not yet recruiting | Yang Li | 364 | 2026-09-01 | 2026-07-30 |
| Suvorexant 3 - PE-PC Suvorexant, Placebo, Prolonged Exposure Therapy for Primary Care (PE-PC) - PTSD - Post Traumatic Stress Disorder, Insomnia | Phase 4 | Not yet recruiting | Northern California Institute of Research and Education | 142 | 2026-09-01 | 2026-07-07 |
| CBITS-RTM Pilot Study Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM) - PTSD - Post Traumatic Stress Disorder, Substance Use | Not applicable | Not yet recruiting | University of California, San Francisco | 28 | 2026-09-01 | 2026-07-06 |
| Propranolol for Early Secondary Prevention of Post-Traumatic Stress Disorder in Women Victims of Sexual Violence Propranolol, 120mg, Placebo - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University Hospital, Tours | 34 | 2026-09-01 | 2026-03-05 |
| Advancing Skills Through Consultation, Education, and Novel Technologies Live workshop, AI-enhanced Web-based training, Consultation video calls - PTSD - Post Traumatic Stress Disorder | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 300 | 2026-08-20 | 2026-11-05 |
| Accelerated Transcranial Magnetic Stimulation for Post-Traumatic Stress Disorder Accelerated functional-connectivity guided transcranial magnetic stimulation - PTSD - Post Traumatic Stress Disorder | Not applicable | Recruiting | Cognitive FX | 15 | 2026-08-14 | 2026-07-28 |
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Combat Disorders (84) · Stress Disorders, Post-Traumatic (55) · Anxiety Disorders (14) · Psychological Well-Being (13) · Depression (12) · Wounds and Injuries (10) · Brain Injuries, Traumatic (7) · Sleep Initiation and Maintenance Disorders (7) · Depressive Disorder, Major (4) · Substance-Related Disorders (4) · Alcoholism (3) · Cognitive Dysfunction (3) · Mental Disorders (3) · Borderline Personality Disorder (2) · Brain Injuries (2)
Trauma and Stressor Related Disorders (84) · Stress Disorders, Traumatic (82) · Mental Disorders (81) · Behavior (26) · Nervous System Diseases (17) · Behavioral Symptoms (14) · Personal Satisfaction (13) · Brain Diseases (10) · Central Nervous System Diseases (10) · Wounds and Injuries (9) · Craniocerebral Trauma (8) · Dyssomnias (8) · Pathological Conditions, Signs and Symptoms (8) · Sleep Disorders, Intrinsic (8) · Sleep Wake Disorders (8)
Eye Movement Desensitization Reprocessing (3) · Hyperbaric Oxygenation (3) · Transcranial Magnetic Stimulation (3) · Cognitive Behavioral Therapy (2) · Cycloserine (2) · Implosive Therapy (2) · Methods (2) · Methoxydimethyltryptamines (2) · Narrative Therapy (2) · Psilocybin (2) · Selective Serotonin Reuptake Inhibitors (2) · Therapeutics (2) · Transcranial Direct Current Stimulation (2) · (11R,13S,17S)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta(a)phenanthren-3-one (1) · 2-cyclohexylidenhydrazo-4-phenyl-thiazole (1)
Asad Ullah Jan (2) · Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA (2) · Johns Hopkins University (2) · Karolinska Institutet (2) · Queen's University, Belfast (2) · Summit Hyperbarics and Wellness (2) · Tel Aviv University (2) · The University of Texas Health Science Center at San Antonio (2) · University Hospital, Tours (2) · University of California, San Francisco (2) · Université de Sherbrooke (2) · VA Office of Research and Development (2) · ARQ National Psychotrauma Centre (1) · Aarhus University Hospital (1) · Acacia Clinics (1)
United States (36) · Canada (5) · Israel (5) · France (3) · Netherlands (3) · Sweden (3) · Switzerland (3) · Denmark (2) · Germany (2) · Jordan (2) · Norway (2) · Pakistan (2) · Ukraine (2) · United Kingdom (2) · Australia (1)
Fidel Vila-Rodriguez, M.D., PhD, FRCPC, DFAPA (2) · Abdallah Alzoubi, MD, PhD (1) · Albert R Powers, MD, PhD (1) · Alice J Wuermli, PhD (1) · Allyson C Rosen, PhD (1) · Ana Lisa Carmo (1) · Andrea Townsend, PhD (1) · Asad Ullah Jan, MBBS,FCPS (1) · Ayman M. Hamdan-Mansour, Professor (1) · Bibhav Acharya, MD (1) · Bradley Watts (1) · Charisse V Ahmed, PhD (1) · Collin Tukuitonga (1) · Davin Quinn, MD (1)
PMID 35816681, PMID 39080752, PMID 40409963, PMID 40964025, PMID 41143444, PMID 41220228, PMID 41248338, PMID 41302196, PMID 41340066, PMID 41546038, PMID 41680806, PMID 42281848, PMID 42469765, PMID 42552899, PMID 42780432
2023 (1), 2025 (1), K23HD115845 (1), K23MH137406 (1), P30AG064198 (1), R01DA059549 (1), R01MH135376 (1), R01NR022445 (1)