14 completed, 2 recruiting, 1 not yet recruiting, 1 terminated. 19 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 19 | Completed 14, Recruiting 2, Not yet recruiting 1, Terminated 1, Unknown 1 |
Follow PTSD: new trials by email Literature Review of PTSD trials Research Report on PTSD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effects of Orexin Antagonism on Fear Extinction in PTSD Suvorexant, Placebo - Insomnia, PTSD | Phase 4 | Not yet recruiting | VA Office of Research and Development | 40120 | 2026-06-01 | 2026-06-02 |
| Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD Dextrose 5% in water bilateral injection, Normal saline bilateral injection - PTSD | Phase 4 | Recruiting | Dr. Dean Reeves Clinic | 50 | 2026-05-16 | 2026-09-16 |
| The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD Ketamine, Magnesium sulfate, Ketamine + Magnesium sulfate - Neuropathic Pain, PTSD | Phase 4 | Recruiting | Margaux M. Salas, PhD | 30 | 2024-10-02 | 2025-02-25 |
| Sequenced Treatment Effectiveness for Posttraumatic Stress Selective serotonin reuptake inhibitor, Serotonin-norepinephrine reuptake inhibitor, Written Exposure Therapy - PTSD | Phase 4 | Completed | University of Washington | 700 | 2020-06-01 | 2025-05-08 |
| Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Minocycline - PTSD | Phase 4 | Completed | Sriram Ramaswamy | 10 | 2017-05-10 | 2020-07-09 |
| The Effect of 21-Days Intranasal Oxytocin on Patients With Post Traumatic Stress Disorder (PTSD) Oxytoine, PLACEBO - PTSD | Phase 4 | Unknown | Rambam Health Care Campus | 40 | 2015-03-01 | 2015-01-13 |
| Dexamethasone Plus Virtual Reality Exposure Therapy for PTSD Virtual reality exposure therapy, 0.5 mg DEX - PTSD | Phase 4 | Completed | Emory University | 27 | 2013-10-01 | 2018-07-12 |
| Vilazodone for the Treatment of Posttraumatic Stress Disorder Treatment (Viibryd) - PTSD, Depression | Phase 4 | Completed | Southern California Institute for Research and Education | 59 | 2012-10-01 | 2017-04-25 |
| Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems Sertraline, Placebo - PTSD, Alcohol Use Disorder | Phase 4 | Completed | The University of Texas Health Science Center at San Antonio | 49 | 2011-04-01 | 2018-04-10 |
| Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy Topiramate, Placebo administration - PTSD, Alcohol Abuse | Phase 4 | Completed | University of California, San Francisco | 30 | 2010-04-01 | 2014-06-03 |
| Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder Placebo, Paroxetine, Positron Emission Tomography (PET) Imaging - PTSD | Phase 4 | Completed | Emory University | 91 | 2009-07-01 | 2017-06-28 |
| Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder Escitalopram - PTSD | Phase 4 | Completed | VA Nebraska Western Iowa Health Care System | 26 | 2008-06-01 | 2019-05-07 |
| A Placebo-Controlled Study of Mirtazapine for PTSD Mirtazapine, Placebo - Anxiety, PTSD | Phase 4 | Completed | US Department of Veterans Affairs | 78 | 2006-04-01 | 2014-11-26 |
| An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder Memantine, Placebo - PTSD | Phase 4 | Completed | Sriram Ramaswamy | 26 | 2005-07-01 | 2020-05-22 |
| Quetiapine Treatment for Post-Traumatic Stress Disorder (PTSD) Quetiapine, Placebo - PTSD | Phase 4 | Completed | Ralph H. Johnson VA Medical Center | 80 | 2003-08-01 | 2008-02-21 |
| Maintenance Phase Treatment With Divalproex for Post Traumatic Stress Disorder Divalproex - PTSD | Phase 4 | Terminated | Tuscaloosa Research & Education Advancement Corporation | 20 | 2003-05-01 | 2017-04-26 |
| Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence Paroxetine CR - PTSD | Phase 4 | Completed | Medical University of South Carolina | 25 | 2003-01-01 | 2007-10-03 |
| Geodon (Ziprasidone) for Posttraumatic Stress Disorder Ziprasidone - Posttraumatic Stress Disorder, Post-Traumatic Stress Disorder | Phase 4 | Completed | Creighton University | 80 | 2002-12-01 | 2006-09-15 |
| Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD) topiramate - PTSD | Phase 4 | Completed | Tuscaloosa Research & Education Advancement Corporation | 40 | 2001-07-01 | 2009-07-29 |
Stress Disorders, Post-Traumatic (19) · Alcoholism (2) · Anxiety Disorders (1) · Depression (1) · Neuralgia (1) · Sleep Initiation and Maintenance Disorders (1) · Substance-Related Disorders (1) · Wounds and Injuries (1) · cyclopia sequence (1)
Mental Disorders (19) · Stress Disorders, Traumatic (19) · Trauma and Stressor Related Disorders (19) · Chemically-Induced Disorders (3) · Alcohol-Related Disorders (2) · Nervous System Diseases (2) · Substance-Related Disorders (2) · Behavior (1) · Behavioral Symptoms (1) · Dyssomnias (1) · Neurologic Manifestations (1) · Neuromuscular Diseases (1) · Pain (1) · Pathological Conditions, Signs and Symptoms (1) · Peripheral Nervous System Diseases (1)
Topiramate (2) · Dexamethasone (1) · Escitalopram (1) · Glucose (1) · Ketamine (1) · Magnesium Sulfate (1) · Magnetic Resonance Spectroscopy (1) · Memantine (1) · Minocycline (1) · Mirtazapine (1) · Paroxetine (1) · Qnexa (1) · Quetiapine Fumarate (1) · Selective Serotonin Reuptake Inhibitors (1) · Sertraline (1)
Emory University (2) · Sriram Ramaswamy (2) · Tuscaloosa Research & Education Advancement Corporation (2) · Creighton University (1) · Dr. Dean Reeves Clinic (1) · Margaux M. Salas, PhD (1) · Medical University of South Carolina (1) · Ralph H. Johnson VA Medical Center (1) · Rambam Health Care Campus (1) · Southern California Institute for Research and Education (1) · The University of Texas Health Science Center at San Antonio (1) · US Department of Veterans Affairs (1) · University of California, San Francisco (1) · University of Washington (1) · VA Nebraska Western Iowa Health Care System (1)
United States (18)
Sriram Ramaswamy, MD (3) · Lori L Davis, MD (2) · Barbara Rothbaum, Ph.D. (1) · Frederick Petty, MD, PhD (1) · James D. Bremner, MD (1) · John D Roache, PhD (1) · Kathleen T Brady, MD, PhD (1) · Kenneth D Reeves, M.D. (1) · Lori L Davis, MD AB (1) · Mark B Hamner, MD (1) · Sabra S Inslicht, PhD (1) · Steven L. Batki, MD (1) · Susan C Sonne, PharmD (1)
PMID 28858440, PMID 33084254, PMID 41091477
R01MH056120 (1)