330 completed, 98 recruiting, 67 unknown, 32 withdrawn. 379 Not applicable, 77 Phase 2, 34 Phase 3, 24 Phase 1, 19 Phase 4.
Follow PTSD: new trials by email Literature Review of PTSD trials Research Report on PTSD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Mental Healthcare Outcomes for Minoritized Veterans Through a Peer-led, Patient Navigation Program (PARTNER-MH 2.0) PARTNER-MH, Educational Brochure - Diagnoses of Depression, Anxiety | Not applicable | Not yet recruiting | VA Office of Research and Development | 268 | 2027-01-04 | 2026-06-16 |
| Postpartum Care in the NICU Multi-Site Breastfeeding NICU-informed postpartum doula support - Postpartum Complication, Postpartum | Not applicable | Not yet recruiting | Children's Hospital of Philadelphia | 640 | 2027-01-01 | 2026-10-19 |
| Facilitating Transition to Recommended PTSD Treatment Treatment As Usual, New Health Services Intervention - PTSD | Not applicable | Not yet recruiting | VA Office of Research and Development | 40 | 2026-12-01 | 2026-08-18 |
| Parenting-STAIR Modular for Military Fathers and OCONUS Families Parenting-STAIR Modular (PSTAIR-M), Treatment as Usual (TAU) - Depressive Symptoms, Emotional Depression | Not applicable | Not yet recruiting | New York University | 243 | 2026-12-01 | 2026-09-30 |
| Rapid Acceleration Process for Intensive Treatment of PTSD in 5 Days Transcranial magnetic stimulation, Sham transcranial magnetic stimulation - PTSD | Phase 3 | Not yet recruiting | VA Office of Research and Development | 90 | 2026-11-16 | 2026-10-05 |
| Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI) Cognitive Behavioral Therapy for Insomnia - Insomnia, Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Madigan Army Medical Center | 144 | 2026-11-01 | 2026-10-22 |
| Individualized (fMRI-guided) TMS Intervention for Post-Traumatic Stress Disorder (PTSD) Active Transcranial Magnetic Stimulation (TMS), Sham Transcranial Magnetic Stimulation (TMS) - PTSD, Post Traumatic Stress Disorder (PTSD) | Early Phase 1 | Not yet recruiting | University of Pennsylvania | 60 | 2026-10-12 | 2026-08-31 |
| Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness ITR Healing intervention - Stress, Trauma | Not applicable | Not yet recruiting | University of Michigan | 90 | 2026-10-05 | 2026-10-02 |
| Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress Disorder TREATMENT ARM: Full dose, CONTROL ARM: Active-controlled - PTSD, Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | U.S. Army Medical Research and Development Command | 86 | 2026-10-01 | 2026-07-15 |
| Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 34 | 2026-10-01 | 2026-09-30 |
| Empowerment Self Defense Program for Adult Native Women Survivors of Sexual Violence Empowerment self-defense training - Depression and Quality of Life, Sexual Violence | Not applicable | Not yet recruiting | University of Michigan | 14 | 2026-09-30 | 2026-08-21 |
| Effects of Stimulant Medications in PTSD Placebo, Adderall - Adderall, PTSD | Phase 1 | Not yet recruiting | University of Chicago | 40 | 2026-09-15 | 2026-06-24 |
| Internet-Delivered Acceptance and Commitment Therapy (iACT) for Youth With PTSD and Chronic Pain iACT - Chronic Pain, PTSD | Not applicable | Recruiting | Skane University Hospital | 10 | 2026-09-01 | 2026-09-10 |
| Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery Cannabidiol (CBD) only, Placebo only, Delta-9-tetrahydrocannabinol (THC) only - PTSD, Post Traumatic Stress Disorder | Phase 1 / Phase 2 | Not yet recruiting | Leslie Lundahl | 280 | 2026-09-01 | 2026-08-26 |
| Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder COMP360 psilocybin - PTSD - Post Traumatic Stress Disorder, PTSD | Phase 2 / Phase 3 | Recruiting | COMPASS Pathways | 300 | 2026-09-01 | 2026-10-23 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback - PTSD, PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University of New Mexico | 150 | 2026-08-31 | 2026-08-04 |
| Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health AIP-Informed Integrative Psychotherapy, Transcutaneous Auricular Vagus Nerve Stimulation, Regulated Breathing and Autonomic Regulation - Anxiety, PTSD | Not applicable | Active not recruiting | Tactical Mind Research Coalition, Inc. | 240 | 2026-08-01 | 2026-09-16 |
| The Efficacy of a Pharmacological Treatment (Reboxetine Plus Ritalin) Versus Dog-Assisted Therapy in PTSD methylphenidate (Ritalin®), Reboxetine, Placebo - PTSD, Posttraumatic Stress Disorder | Phase 2 | Recruiting | University of Haifa | 160 | 2026-08-01 | 2026-08-18 |
| Exposure by Assessment: Effects of Daily AMQ-Based EMA of an Intrusive Trauma Memory in PTSD AMQ-based ecological momentary assessment of an intrusive memory, AMQ-based ecological momentary assessment of an emotionally neutral memory - PTSD | Not applicable | Recruiting | Tel Aviv University | 50 | 2026-06-14 | 2026-06-25 |
| FLOAT for Healthcare PTSS Floatation-REST, Documentary - Posttraumatic Stress Symptoms, Burnout | Early Phase 1 | Recruiting | Laureate Institute for Brain Research, Inc. | 15 | 2026-06-10 | 2026-07-17 |
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Stress Disorders, Post-Traumatic (616) · Depression (108) · Anxiety Disorders (91) · Wounds and Injuries (40) · Alcoholism (27) · Psychological Well-Being (25) · Substance-Related Disorders (23) · Chronic Pain (18) · Brain Injuries, Traumatic (16) · Combat Disorders (16) · Mental Disorders (14) · Psychological Trauma (12) · Suicidal Ideation (12) · Bipolar Disorder (11) · Depressive Disorder, Major (11)
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Therapeutics (22) · 2-cyclohexylidenhydrazo-4-phenyl-thiazole (15) · Cognitive Behavioral Therapy (14) · N-Methyl-3,4-methylenedioxyamphetamine (10) · Psilocybin (10) · Ketamine (8) · Psychotherapy (7) · Transcranial Magnetic Stimulation (7) · Eye Movement Desensitization Reprocessing (6) · Exercise (5) · Neurofeedback (5) · Oxytocin (5) · Sodium Chloride (5) · Yoga (5) · Hydrocortisone (4)
VA Office of Research and Development (70) · Medical University of South Carolina (16) · Stanford University (9) · US Department of Veterans Affairs (9) · University of Washington (8) · University of Wisconsin, Madison (8) · Yale University (8) · Emory University (7) · Tel Aviv University (7) · The University of Texas Health Science Center at San Antonio (7) · Tonix Pharmaceuticals, Inc. (7) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (6) · University of Zurich (6) · Ohio State University (5) · Resilient Pharmaceuticals (5)
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Christine E Marx, MD, MA (3) · Denise Bedoya (3) · Joseph Zohar, MD (3) · Julian Ford, Ph.D. (3) · Michael R Koenigs, PhD (3) · Sriram Ramaswamy, MD (3) · Yair Bar-Haim, PhD (3) · Yuval Neria, PhD (3) · Adriana Feder, MD (2) · Alicia Heapy, Ph.D. (2) · Ane-Marthe S Skar, PhD (2) · Anne G. Sadler, PhD RN (2) · Ariel J. Lang, PhD (2) · Bradley V Watts, MD, MPH (2) · Christal Badour, PhD (2)
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R44MH136888 (2), 1IK2HX003339-01A2 (1), 1IK2RX001492-01A1 (1), 1RC1AA019019-01 (1), 1RC1MH088969-01 (1), 1UL1TR002384 (1), 1UL1TR002384-02 (1), 2016 (1), 2017 (1), 2019 (1), 2023 (1), 2025 (1), DP1MH116506 (1), I01CX000467 (1), I01CX001789 (1)