160 completed, 61 unknown, 57 recruiting, 19 terminated. 214 Not applicable, 21 Phase 2, 21 Phase 4, 13 Phase 3, 11 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis MANOEUVRE therapy - Psychosis, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Not yet recruiting | King's College London | 15 | 2027-09-01 | 2026-06-03 |
| Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis Smartphone-based Mindfulness Exercise, Smartphone-based Psychoeducation, Neutral Control Message - Psychosis, Anxiety | Not applicable | Not yet recruiting | Mclean Hospital | 10 | 2027-01-15 | 2026-10-05 |
| Stratification and Treatment in Early Psychosis Study -ASSIST CBD 100 mg/mL Oral Solution, Placeb - Treatment Resistant Psychosis, Psychosis | Phase 3 | Not yet recruiting | University of Oxford | 250 | 2027-01-01 | 2026-10-08 |
| Online Intervention To Improve Motivation Online Motivation Enhancing Intervention - Schizophrenia Prodromal, SCHIZOPHRENIA 1 (Disorder) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2026-12-01 | 2026-10-13 |
| Stratification and Treatment in Early Psychosis Study - ENHANCE CBD 100 mg/mL Oral Solution, Placebo - Psychosis, First Episode Psychosis | Phase 3 | Recruiting | University of Oxford | 250 | 2026-10-05 | 2026-10-08 |
| Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis Suicide Prevention Intervention, Standard Care (in control arm) - Clinical High Risk for Psychosis (CHR), Suicidal Ideation | Not applicable | Recruiting | University of California, San Diego | 108 | 2026-10-01 | 2026-10-22 |
| Group Dialectical Behaviour Therapy (DBT) Skills Training for First Episode Psychosis group DBT - Psychosis | Not applicable | Not yet recruiting | Centre for Addiction and Mental Health | 32 | 2026-09-15 | 2026-09-16 |
| Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis CHAMPS, I Can Change - First Episode Psychosis (FEP), Psychosis | Not applicable | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 550 | 2026-09-15 | 2026-09-10 |
| Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia Accelerated iTBS, High-Frequency rTMS, Sham rTMS - Psychosis, Schizophrenia Disorder | Not applicable | Not yet recruiting | All India Institute of Medical Sciences, Bhubaneswar | 90 | 2026-09-15 | 2026-08-10 |
| Building a Computational Model of Auditory Hallucinations Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature | Not yet recruiting | King's College London | 146 | 2026-09-01 | 2026-09-15 | |
| Cognitive Strategies in Early Psychosis 2 Modafinil, D-serine solution, Placebo - Psychosis, Schizophrenia Disorder | Phase 3 | Recruiting | University of Minnesota | 24 | 2026-07-17 | 2026-07-23 |
| Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar Disorder Group-Based Psychoeducation, Peer Support, Personalized Support for Community Healthcare Provider - Bipolar Disorder (BD), Psychosis | Not applicable | Recruiting | McMaster University | 10 | 2026-06-01 | 2026-10-06 |
| The Mouth Matters in Mental Health Trial -2 Link work intervention - Mental Health, Oral Health Care | Not applicable | Recruiting | Lancashire and South Cumbria NHS Foundation Trust | 480 | 2026-05-01 | 2026-07-27 |
| Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis Action-Based Cognitive Remediation - Psychosis, Alcohol Use Disorder | Not applicable | Recruiting | Nova Scotia Health Authority | 50 | 2026-03-27 | 2026-04-07 |
| A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5) KarXT, KarX-EC, KarXT + KarX-EC Arm Matching Placebo - Alzheimer Disease, Psychosis | Phase 3 | Recruiting | Bristol-Myers Squibb | 325 | 2026-03-25 | 2026-06-30 |
| Improving Health Literacy in Patients With Schizophrenia Spectrum Disorder Educational sessions - Schizophrenia Disorder, Schizoaffective Disorder | Not applicable | Not yet recruiting | Louisiana State University Health Sciences Center in New Orleans | 34 | 2026-03-01 | 2026-03-23 |
| A Case Series of Culturally-adapted CBTp for Black People in the UK Culturally-adapted cognitive-behavioural therapy - Psychosis, Schizophrenia Spectrum Disorders | Not applicable | Recruiting | University of Manchester | 6 | 2026-02-24 | 2026-07-10 |
| Early Psychosis: Investigating Cognition Transcranial direct current stimulation (tDCS), Magnetic Resonance Imaging - First Episode Psychosis (FEP), Psychosis | Not applicable | Recruiting | University of Nottingham | 106 | 2026-02-09 | 2026-05-04 |
| What is the Feasibility of Narrative Exposure Therapy (NET) for People Experiencing Psychosis? Narrative Exposure Therapy (NET) - Psychosis, Schizophrenia and Other Psychotic Disorders | Not applicable | Not yet recruiting | University of Nottingham | 1 | 2026-02-05 | 2026-02-02 |
| Strategic Timing of Resistance Training to Guard Against Antipsychotic-Induced Metabolic Syndrome Resistance training programme - Psychosis | Not applicable | Not yet recruiting | University College Dublin | 40 | 2026-02-01 | 2026-02-09 |
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Psychotic Disorders (343) · Schizophrenia (140) · Bipolar Disorder (34) · Mental Disorders (32) · Depression (17) · Anxiety Disorders (12) · Substance-Related Disorders (12) · Psychological Well-Being (10) · Schizophrenia Spectrum and Other Psychotic Disorders (10) · Hallucinations (9) · Depressive Disorder, Major (7) · Mania (7) · Marijuana Abuse (7) · Schizotypal Personality Disorder (7) · Stress Disorders, Post-Traumatic (7)
Schizophrenia Spectrum and Other Psychotic Disorders (333) · Mental Disorders (311) · Behavior (62) · Pathological Conditions, Signs and Symptoms (51) · Nervous System Diseases (43) · Signs and Symptoms (43) · Behavioral Symptoms (35) · Bipolar and Related Disorders (34) · Mood Disorders (34) · Neurologic Manifestations (34) · Neurobehavioral Manifestations (28) · Chemically-Induced Disorders (24) · Neurocognitive Disorders (15) · Nutritional and Metabolic Diseases (13) · Social Behavior (12)
Therapeutics (15) · Cognitive Behavioral Therapy (11) · Risperidone (9) · Transcranial Direct Current Stimulation (7) · Aripiprazole (6) · Cognitive Remediation (6) · Motivational Interviewing (6) · Haloperidol (4) · Palliative Care (4) · Psychosocial Intervention (4) · Acceptance and Commitment Therapy (3) · Clozapine (3) · PRIME protocol (3) · Standard of Care (3) · Acetylcysteine (2)
King's College London (15) · Centre for Addiction and Mental Health (14) · University of Minnesota (14) · Mclean Hospital (9) · Douglas Mental Health University Institute (8) · University of Manchester (8) · Pakistan Institute of Living and Learning (7) · University of British Columbia (7) · VA Office of Research and Development (6) · Yale University (6) · Nova Scotia Health Authority (5) · University of North Carolina, Chapel Hill (5) · University of Washington (5) · Center for Social Innovation, Massachusetts (4) · Fundació Sant Joan de Déu (4)
United States (118) · Canada (47) · United Kingdom (38) · Spain (20) · Germany (15) · Hong Kong (11) · France (10) · Norway (9) · Switzerland (9) · Denmark (8) · Pakistan (7) · Ireland (6) · Netherlands (6) · China (5) · Italy (5)
Sophia Vinogradov, MD (10) · Philip G Tibbo, MD (3) · Andrew Gumley (2) · Benedicto Crespo-Facorro, Professor (2) · Brandon Kohrt, MD, PhD (2) · Chen-Chung Liu, MD, PhD (2) · Donald Goff, MD (2) · Dror Ben-Zeev, PhD (2) · Elizabeth A. Klingaman, PhD (2) · Farooq Naeem, MRCPsych (2) · George Foussias, MD, PhD (2) · Imran Chaudhry, MD (2) · Jeffrey Olivet, MA (2) · Joanna M. Fiszdon, PhD (2)
PMID 26493637, PMID 29207980, PMID 31902581, PMID 34004383, PMID 34662778, PMID 42629434, PMID 10689661, PMID 12362963, PMID 15531404, PMID 17452283, PMID 17539698, PMID 17905167, PMID 18310597, PMID 18664995, PMID 19036233, PMID 19324499, PMID 20688481, PMID 20815872, PMID 21755540, PMID 21845596, PMID 22075649, PMID 22398127, PMID 22647399, PMID 23274298, PMID 23890106, PMID 24382883, PMID 24839887, PMID 24983382, PMID 25015535, PMID 25062592, PMID 25205258, PMID 25348346, PMID 25936396, PMID 26597630, PMID 26598473, PMID 26784704, PMID 26969299, PMID 27147592, PMID 27372845, PMID 27547853, PMID 27617637, PMID 28057452, PMID 28102978, PMID 28253083, PMID 28302703, PMID 28368179, PMID 28599949, PMID 28675695, PMID 28709880, PMID 28965778
P50MH119569 (4), 2009 (2), 2025 (2), K23DA050808 (2), R01MH120589 (2), R34MH123609 (2), 1IK2RX001836-01A1 (1), 1RC1MH088546 (1), 2018 (1), 2019 (1), I01RX003213 (1), K23AA017666 (1), K23MH091210 (1), K23MH102358 (1), K23MH118373 (1)