8 completed, 2 active not recruiting, 1 terminated. 5 Not applicable, 4 Phase 1, 4 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 3, Active not recruiting 2 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow PRIME protocol: new trials by email Literature Review of PRIME protocol trials Research Report on PRIME protocol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EPI-MINN: Targeting Cognition and Motivation - National Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care - Psychosis, Psychosis Nos/Other | Not applicable | Active not recruiting | University of Minnesota | 55 | 2023-05-30 | 2026-07-10 |
| EPI-MINN: Targeting Cognition and Motivation Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care - Psychosis | Not applicable | Active not recruiting | University of Minnesota | 400 | 2021-08-12 | 2026-08-07 |
| Evaluate the Safety, Immunogenicity and Potential Efficacy of an rVSV-SARS-CoV-2-S Vaccine IIBR-100, low dose (prime), IIBR-100 medium dose (prime), IIBR-100 high-dose (prime) - Covid19 | Phase 1 / Phase 2 | Completed | Israel Institute for Biological Research (IIBR) | 843 | 2020-10-28 | 2023-11-18 |
| Investigating a Vaccine Against COVID-19 ChAdOx1 nCoV-19 (Abs 260), MenACWY vaccine, ChAdOx1 nCoV-19 (Abs 260) + 2.2x10^10vp (qPCR) boost - Coronavirus | Phase 2 / Phase 3 | Completed | University of Oxford | 10811 | 2020-05-28 | 2025-09-03 |
| Clinical Performance of Adhesive Systems Containing HEMA and 10-MDP in Non Carious Cervical Lesions composite resin restoration - Non Carious Cervical Lesion | Not applicable | Completed | Universidade Federal do Para | 18 | 2020-02-12 | 2022-05-24 |
| Neuronal Correlates of Priming on Goal-directed and Cue-dependent Behavior prime - Functional Magnetic Resonance Imaging, Habits | Completed | University Hospital Tuebingen | 38 | 2019-02-01 | 2024-12-05 | |
| Cognitive Training Delivered Remotely to Individuals With Psychosis (ROAM) Structured Cognitive Training & PRIME, Computer Games Control & PRIME - Treatment, Active Control | Not applicable | Completed | University of Minnesota | 109 | 2016-09-01 | 2022-06-08 |
| Reducing Stigma Among Healthcare Providers to Improve Mental Health Services RESHAPE, PRIME/mhGAP - Mental Disorders | Not applicable | Completed | Brandon A Kohrt, MD, PhD | 88 | 2016-02-01 | 2026-07-22 |
| Safety and Immunogenicity of ChAdV63.HIVconsv and MVA.HIVconsv Candidate HIV-1 Vaccines in Recently HIV-1 Infected Individuals 0-24 week prime/boost regimen, 0-8 week prime/boost regimen - HIV | Phase 1 | Completed | IrsiCaixa | 48 | 2012-10-01 | 2024-05-07 |
| Immunogenicity of Adjuvanted or Non-adjuvanted H5N1 Booster Vaccine in Adults Primed to A/VN/1194/04 Aflunov (Single prime, single boost), Aflunov (single prime, single boost), Aflunov (Double prime, single boost) - Influenza | Phase 1 / Phase 2 | Completed | University Hospitals, Leicester | 606 | 2008-11-01 | 2014-06-03 |
| Thai Prophylactic HIV Vaccine Phase I Study pHIS-HIV-AE (DNA vaccine) prime and rFPV-HIV-AE (recombinant fowlpox virus boost) vaccine - HIV | Phase 1 / Phase 2 | Terminated | Kirby Institute | 8 | 2007-08-01 | 2012-06-13 |
Psychotic Disorders (3) · COVID-19 (2) · Mental Disorders (2) · Schizophrenia (2) · Acquired Immunodeficiency Syndrome (1) · Affective Disorders, Psychotic (1) · Bipolar Disorder (1) · Cognitive Dysfunction (1) · Coronavirus Infections (1) · Depression (1) · Feeding Behavior (1) · Habits (1) · Influenza, Human (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1) · Schizotypal Personality Disorder (1)
University of Minnesota (3) · Brandon A Kohrt, MD, PhD (1) · IrsiCaixa (1) · Israel Institute for Biological Research (IIBR) (1) · Kirby Institute (1) · Universidade Federal do Para (1) · University Hospital Tuebingen (1) · University Hospitals, Leicester (1) · University of Oxford (1)
United States (3) · United Kingdom (2) · Brazil (1) · Germany (1) · Israel (1) · Nepal (1) · Spain (1) · Thailand (1)
Sophia Vinogradov, MD (3) · Andrew Pollard, Prof (1) · Beatriz Mothe, MD,PhD (1) · Brandon A Kohrt, MD, PhD (1) · Brennda De Paula, Msc (1) · Cecy Silva, PhD (1) · Christian Brander, PhD (1) · Karl G Nicholson, FRCP, MD (1) · Kiat Ruxrungtham, MD PhD (1) · Piper Meyer-Kalos, PhD (1) · Roberta Oliveira, Msc (1)
PMID 20864808, PMID 29403650, PMID 29902036, PMID 31312806, PMID 33220855, PMID 33306989, PMID 33335323, PMID 33617777, PMID 33798499, PMID 34153264, PMID 34480858, PMID 34730821, PMID 35192543, PMID 35953839, PMID 37955951, PMID 41106035
R01MH120589 (2), K01MH104310 (1)