14 completed, 6 unknown, 4 recruiting, 3 not yet recruiting. 29 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 29 | Completed 14, Unknown 6, Recruiting 4, Not yet recruiting 3, Terminated 2 |
Follow Primary Dysautonomias: new trials by email Literature Review of Primary Dysautonomias trials Research Report on Primary Dysautonomias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial) Tamsulosin hydrochloride 0.2 mg, Placebo - Benign Prostatic Hyperplasia | Phase 4 | Not yet recruiting | Shanghai East Hospital | 400 | 2026-12-01 | 2026-09-29 |
| Autonomic and Renal Contributions to Hypertension With ADT Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor, Placebo - Androgen Deprivation Therapy, Prostate Cancer | Phase 4 | Recruiting | Virginia Commonwealth University | 50 | 2026-08-01 | 2026-09-30 |
| Low Dose Naltrexone Use in Patients With POTS Low Dose Naltrexone, Microcrystalline cellulose - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Not yet recruiting | University of Calgary | 80 | 2026-07-01 | 2026-05-01 |
| Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition 5 mL of 0.25% bupivacaine with epinephrine (1:200,000), Placebo (Saline) Control - Autonomic Dysfunction | Phase 4 | Recruiting | University Health Network, Toronto | 78 | 2026-05-19 | 2026-10-09 |
| LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery Landiolol - Perioperative Myocardial Injury, Autonomic Dysfunction | Phase 4 | Recruiting | Insel Gruppe AG, University Hospital Bern | 114 | 2026-04-24 | 2026-05-05 |
| Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome Low sodium oxybate (LXB), Placebo - Idiopathic Hypersomnia, POTS - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Not yet recruiting | Stanford University | 25 | 2025-10-01 | 2025-07-25 |
| Efficacy and Safety of Vespireit, Prolonged-release Tablets, in Patients With Autonomic Dysfunction Syndrome Accompanied by Functional Vertigo Vespireit, Arlevert - Vertigo, Autonomic Dysfunction | Phase 4 | Recruiting | Valenta Pharm JSC | 160 | 2024-01-24 | 2025-06-15 |
| Contributions to Hypertension With Androgen Deprivation Therapy Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor, Placebo - Androgen Deprivation Therapy, Prostate Cancer | Phase 4 | Terminated | University of Colorado, Denver | 10 | 2023-09-20 | 2026-09-02 |
| Ivabradine for Long-Term Effects of COVID-19 With POTS Cohort Ivabradine - Long Haul COVID, Postural Orthostatic Tachycardia Syndrome | Phase 4 | Unknown | Uniformed Services University of the Health Sciences | 250 | 2023-06-14 | 2023-11-29 |
| RaGuS Trial by Postoperative Patients Midodrine Hydrochloride, Placebo - Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction | Phase 4 | Unknown | Bürgerspital Solothurn | 50 | 2020-09-14 | 2020-06-19 |
| Trial of Parkinson's And Zoledronic Acid Zoledronic Acid 5Mg/Bag 100Ml Inj, Placebo - Parkinson Disease, Osteoporosis | Phase 4 | Completed | California Pacific Medical Center Research Institute | 2721 | 2019-11-15 | 2026-06-25 |
| Lundbeck TOMs Orthostatic Hypotension Droxidopa 100 MG [Northera] - Orthostatic Hypotension, Idiopathic Parkinson Disease | Phase 4 | Completed | Alberto Espay, MD, MSc | 9 | 2019-02-11 | 2022-09-26 |
| Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury Northera, Placebo - Hypotension, Orthostatic, Hypotension | Phase 4 | Completed | James J. Peters Veterans Affairs Medical Center | 22 | 2018-06-01 | 2025-03-07 |
| Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH Midodrine, Atomoxetine - Neurogenic Orthostatic Hypotension | Phase 4 | Completed | Seoul National University Hospital | 50 | 2018-01-01 | 2019-04-05 |
| Dawn Simulation and Postural Hypotension Light - Orthostatic Hypotension | Phase 4 | Completed | VA Palo Alto Health Care System | 35 | 2016-09-01 | 2019-10-25 |
| Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Droxidopa capsules, Placebo capsules - Symptomatic Neurogenic Orthostatic Hypotension | Phase 4 | Completed | H. Lundbeck A/S | 453 | 2016-02-11 | 2023-08-23 |
| Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Metoprolol, Matching Placebo - Vasovagal Syncope | Phase 4 | Unknown | University of Calgary | 52 | 2014-10-01 | 2024-05-09 |
| Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS) Propranolol, Bisoprolol, Propranolol+pyridostigmine - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Completed | Seoul National University Hospital | 150 | 2014-03-01 | 2018-04-18 |
| Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Midodrine HCl, Placebo - Orthostatic Hypotension | Phase 4 | Completed | Shire | 24 | 2012-05-14 | 2021-06-08 |
| Optimal Balloon Catheter Placement During Sonohysterography sonohysterography with inflated catheter in uterine cavity, sonohysterography with inflated catheter in cervical cavity - Infertility | Phase 4 | Completed | Royan Institute | 300 | 2012-05-01 | 2014-05-06 |
Showing 20 of 29. Sign in to see all of them.
Hypotension, Orthostatic (10) · Syncope, Vasovagal (6) · Parkinson Disease (4) · Postural Orthostatic Tachycardia Syndrome (4) · Multiple System Atrophy (3) · Hypertension (2) · Kidney Diseases (2) · Prostatic Neoplasms (2) · Autonomic Nervous System Diseases (1) · Fibromyalgia (1) · Fractures, Bone (1) · Hypotension (1) · Idiopathic Hypersomnia (1) · Infertility (1)
Nervous System Diseases (29) · Autonomic Nervous System Diseases (28) · Orthostatic Intolerance (19) · Cardiovascular Diseases (12) · Vascular Diseases (12) · Pathological Conditions, Signs and Symptoms (11) · Hypotension (9) · Signs and Symptoms (9) · Neurologic Manifestations (8) · Consciousness Disorders (6) · Neurobehavioral Manifestations (6) · Syncope (6) · Unconsciousness (6) · Central Nervous System Diseases (5)
Midodrine (7) · Droxidopa (3) · Flutamide (2) · Leuprolide (2) · Propranolol (2) · Receptors, Androgen (2) · bicalutamide (2) · Atomoxetine Hydrochloride (1) · Bisoprolol (1) · Bupivacaine (1) · Epinephrine (1) · Goserelin (1) · Idoxuridine (1) · Ivabradine (1) · Metoprolol (1)
Shire (4) · University of Calgary (3) · Seoul National University Hospital (2) · Alberto Espay, MD, MSc (1) · Bürgerspital Solothurn (1) · California Pacific Medical Center Research Institute (1) · Dr. Bob Sheldon (1) · Federal University of Espirito Santo (1) · H. Lundbeck A/S (1) · Insel Gruppe AG, University Hospital Bern (1) · James J. Peters Veterans Affairs Medical Center (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Royan Institute (1) · Shanghai East Hospital (1) · Spanish Society of Cardiology (1)
United States (15) · Canada (4) · South Korea (2) · Brazil (1) · Iran (1) · Poland (1) · Russia (1) · Spain (1) · Switzerland (1)
Matthew Babcock, PhD (2) · Antonella Giannantoni, M.D. (1) · Anuj Bhatia, MD, PhD (1) · Chu Kon (1) · David L Saunders, MD, MPH (1) · Fatemeh Zafarani, MSc (1) · Firoozeh Ahmadi, MD (1) · Hamid Gourabi, PhD (1) · Jill M Wecht, Ed.D (1) · Kon Chu, MD, PhD (1) · Marcos Delgado, MD (1) · Maria Bernadete RO Gavi, Master (1)
PMID 16781217, PMID 22610268, PMID 23845791, PMID 24651512, PMID 26492477, PMID 26953217, PMID 26995374, PMID 27364043, PMID 27372462, PMID 28327122, PMID 28958328, PMID 29223724, PMID 29500811, PMID 29766871, PMID 31107279, PMID 31334462, PMID 31713631, PMID 32145658, PMID 32307533, PMID 33649343, PMID 34339231, PMID 35107750, PMID 40692561, PMID 42609753
K01HL164978 (1), R01AG059417 (1)