23 completed, 11 active not recruiting, 7 recruiting, 3 unknown. 25 Not applicable, 5 Early Phase 1, 5 Phase 2, 3 Phase 1, 1 Phase 3.
Follow Postural Tachycardia Syndrome: new trials by email Literature Review of Postural Tachycardia Syndrome trials Research Report on Postural Tachycardia Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity breathing exercise training - Postural Tachycardia Syndrome | Not applicable | Not yet recruiting | Virginia Commonwealth University | 12 | 2028-01-01 | 2026-09-16 |
| Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome Stellate ganglion block, Sham injection of saline, Ropivacaine - Postural Tachycardia Syndrome | Not applicable | Not yet recruiting | Stanford University | 20 | 2025-10-13 | 2025-10-15 |
| Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) GammaCore intervention, STEPS management protocol - Postural Tachycardia Syndrome, Autonomic Dysfunction | Not applicable | Completed | Mayo Clinic | 40 | 2024-02-14 | 2025-10-31 |
| Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities? Looming task - Postural Tachycardia Syndrome | Not applicable | Recruiting | Virginia Commonwealth University | 36 | 2023-03-06 | 2026-04-21 |
| VNS for Long-COVID-19 Non-invasive vagus nerve stimulation, Sham Intervention - Post-COVID-19 Syndrome, Postural Tachycardia Syndrome | Not applicable | Completed | Icahn School of Medicine at Mount Sinai | 40 | 2022-11-11 | 2024-11-08 |
| Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention. Time restricted eating - Postural Tachycardia Syndrome | Not applicable | Unknown | University of California, San Diego | 25 | 2022-07-01 | 2024-08-20 |
| Inappropriate Sinus Tachycardia Registry AtriCure Commercially Available Devices - Inappropriate Sinus Tachycardia, Postural Tachycardia Syndrome | Recruiting | AtriCure, Inc. | 500 | 2022-03-01 | 2026-10-07 | |
| A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia Syndrome Embr Device - Postural Tachycardia Syndrome | Not applicable | Completed | Stanford University | 23 | 2022-02-27 | 2024-10-08 |
| fMRI in Postural Tachycardia Syndrome Lower Body Negative Pressure, Sham Pressure - Postural Tachycardia Syndrome | Not applicable | Active not recruiting | Milton S. Hershey Medical Center | 21 | 2022-02-18 | 2026-09-24 |
| Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome RespirAct™ system (Thornhill Research Inc., Toronto, Canada) - Postural Tachycardia Syndrome, Orthostatic Intolerance | Not applicable | Recruiting | University of Calgary | 26 | 2022-02-02 | 2026-05-07 |
| Autoimmune Basis for Postural Tachycardia Syndrome Vagal stimulation, Sham stimulation - Postural Tachycardia Syndrome | Not applicable | Completed | University of Oklahoma | 80 | 2022-01-14 | 2026-07-29 |
| Autonomic Determinants of POTS - Pilot 2 Placebo oral tablet, Moxonidine Pill - Postural Tachycardia Syndrome | Early Phase 1 | Active not recruiting | Vanderbilt University Medical Center | 48 | 2021-08-31 | 2026-03-27 |
| Crossover Study of Propranolol vs Ivabradine in POTS Ivabradine 4-week course, Propranolol 4-week course, Placebo 4-week course - Postural Tachycardia Syndrome | Phase 2 | Recruiting | University of Calgary | 20 | 2021-02-01 | 2024-05-09 |
| Muscular and Cutaneous Dysfunction in POTS Patient and Healthy Volunteers training protocol - Postural Tachycardia Syndrome | Not applicable | Completed | Insel Gruppe AG, University Hospital Bern | 15 | 2020-01-10 | 2025-03-10 |
| Long-term Effects of Transcutaneous Vagal Nerve Stimulation on Postural Orthostatic Tachycardia Syndrome (POTS) Transcutaneous vagal nerve stimulation (tVNS), Placebo, Home daily transcutaneous vagal nerve stimulation - Orthostatic Intolerance, Postural Tachycardia Syndrome | Not applicable | Unknown | Istituto Clinico Humanitas | 23 | 2019-11-10 | 2022-06-30 |
| Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry No intervention planned, but all patients get our standart treatment - Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type | Recruiting | RWTH Aachen University | 200 | 2019-09-15 | 2025-02-04 | |
| Autonomic Determinants of POTS - Pilot1 Moxonidine, Placebo - Postural Tachycardia Syndrome | Early Phase 1 | Active not recruiting | Vanderbilt University Medical Center | 48 | 2019-08-27 | 2026-03-27 |
| IVIG (Gamunex-C) Treatment Study for POTS Subjects IVIG, Albumin - Postural Tachycardia Syndrome | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 30 | 2018-10-29 | 2024-09-19 |
| Hemodynamic Effects of Compression in POTS LifeWrap Compression Garment - Postural Tachycardia Syndrome | Not applicable | Completed | University of Calgary | 32 | 2018-07-12 | 2021-10-22 |
| Standing Cognition and Co-morbidities of POTS Evaluation Standing, Supine - Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome | Not applicable | Completed | Milton S. Hershey Medical Center | 139 | 2018-06-23 | 2021-04-14 |
Showing 20 of 49. Sign in to see all of them.
Postural Orthostatic Tachycardia Syndrome (49) · Orthostatic Intolerance (15) · Autonomic Nervous System Diseases (8) · Tachycardia (5) · Primary Dysautonomias (4) · Syncope (4) · Syncope, Vasovagal (3) · Cardiovascular Diseases (2) · Cognitive Dysfunction (2) · Ehlers-Danlos Syndrome (2) · Anxiety Disorders (1) · Arrhythmias, Cardiac (1) · Ehlers-Danlos syndrome type 3 (1) · Fatigue Syndrome, Chronic (1) · Intermittent Fasting (1)
Nervous System Diseases (48) · Primary Dysautonomias (45) · Autonomic Nervous System Diseases (41) · Orthostatic Intolerance (34) · Pathological Conditions, Signs and Symptoms (20) · Signs and Symptoms (19) · Neurologic Manifestations (17) · Pathologic Processes (7) · Consciousness Disorders (6) · Mental Disorders (6) · Neurobehavioral Manifestations (6) · Unconsciousness (6) · Cardiac Conduction System Disease (5) · Cardiovascular Diseases (5) · Heart Diseases (5)
Saline Solution (4) · Phenylephrine (3) · Vagus Nerve Stimulation (3) · Blood Specimen Collection (2) · Isoproterenol (2) · Ivabradine (2) · Propranolol (2) · Pyridostigmine Bromide (2) · Supine Position (2) · moxonidine (2) · Albumins (1) · Ascorbic Acid (1) · Blood Pressure (1) · Blood Pressure Monitors (1) · Breathing Exercises (1)
Vanderbilt University Medical Center (9) · Vanderbilt University (8) · University of Calgary (4) · Insel Gruppe AG, University Hospital Bern (2) · Mayo Clinic (2) · Milton S. Hershey Medical Center (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · Nationwide Children's Hospital (2) · New York Medical College (2) · RWTH Aachen University (2) · Satish R. Raj (2) · Stanford University (2) · Virginia Commonwealth University (2) · Alfredo Gamboa (1) · AtriCure, Inc. (1)
United States (39) · Canada (4) · Germany (2) · Italy (2) · Switzerland (2) · Belgium (1) · Poland (1)
Satish R Raj, MD MSCI (6) · Alfredo J Gamboa, MD (3) · Italo Biaggioni, MD (3) · Satish R Raj, MD, MSCI (3) · Werner Z'Graggen, MD (2) · Amanda J Miller, Ph.D. (1) · Amy Arnold, Ph.D. (1) · Andrea Maier (1) · Andrea Maier, Dr. (1) · Dana Shiffer, MD (1) · David Putrino, PT, PhD (1) · David S Goldstein, M.D. (1) · Emily M Garland, PhD (1)
PMID 21906029, PMID 23283362, PMID 25792354, PMID 30256820, PMID 33478652, PMID 33486983, PMID 36300662, PMID 36437696, PMID 37261636, PMID 37999672, PMID 41747483
K23RR020783 (2), R01HL102387 (2), UL1RR024975 (2), 2017 (1), 5UL1TR000445-07 (1), P01HL056693 (1), P01NS044233 (1), R01HL128393 (1), R01HL142583 (1), R56HL142583 (1), UL1TR002014 (1)