9 completed, 5 unknown, 2 terminated, 2 withdrawn. 19 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 19 | Completed 9, Unknown 5, Terminated 2, Withdrawn 2, Recruiting 1 |
Follow Pleural Effusion: new trials by email Literature Review of Pleural Effusion trials Research Report on Pleural Effusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily - Pleural Infection Bacterial, Pleural Infections | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 270 | 2025-09-11 | 2026-09-29 |
| Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion thoracoscope - Malignant Pleural Effusions (Mpe)- Pleurodesis, Pleurodesis | Phase 4 | Completed | Mohamed Sabry | 60 | 2024-09-01 | 2024-12-20 |
| Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis lidocaine 2.5% and prilocaine 2.5% cream in pain management before pleurocentesis. - Pleural Effusion | Phase 4 | Unknown | Assiut University | 118 | 2023-01-01 | 2023-08-09 |
| Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures Diclofenac, Placebo - Pleural Neoplasms, Aspiration, Respiratory | Phase 4 | Unknown | Assiut University | 100 | 2021-11-01 | 2021-11-16 |
| Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis Cathflo Activase, Talc Slurry Pleurodesis - Pleural Effusion | Phase 4 | Completed | Memorial Healthcare System | 27 | 2021-06-15 | 2025-06-08 |
| Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion Talc - Malignant Pleural Effusion | Phase 4 | Terminated | Duke University | 4 | 2021-03-18 | 2023-09-28 |
| A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation - Pleural Effusion, Malignant, Pleural Mesothelioma | Phase 4 | Unknown | Mohamed Reda Ashour | 40 | 2020-01-15 | 2021-10-14 |
| Betadine Pleurodesis Via Tunneled Pleural Catheters Povidone-Iodine - Pleural Effusion, Pleurodesis | Phase 4 | Withdrawn | Yale University | 2018-07-01 | 2019-01-11 | |
| Diaphragmatic Resection And Gynecological Ovarian Neoplasm thoracic Drain Tube 24 Fr. - Ovarian Cancer | Phase 4 | Completed | Catholic University of the Sacred Heart | 88 | 2018-03-20 | 2020-05-22 |
| Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital streptokinase, MESNA (2-mercaptoethane sulfonate Na), Medical thoracoscopy - Pleural Effusion | Phase 4 | Unknown | Assiut University | 100 | 2017-08-01 | 2017-06-06 |
| Early Intrapleural TPA Instillation Versus Late early tPA and DNase - Tissue Plasminogen Activator | Phase 4 | Withdrawn | Prisma Health-Midlands | 2017-02-17 | 2025-02-21 | |
| Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis Questionnaires, Fentanyl Patch, Fentanyl (IV) - Advanced Cancers, Malignant Pleural Effusions | Phase 4 | Terminated | M.D. Anderson Cancer Center | 3 | 2016-04-27 | 2019-08-07 |
| Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Ketotifen, Placebo - Dengue Fever, Pleural Effusion | Phase 4 | Unknown | National University Hospital, Singapore | 110 | 2015-03-01 | 2016-02-04 |
| Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Cefazolin, saline - Pleural Effusion, Pleurisy | Phase 4 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 100 | 2015-01-01 | 2017-01-18 |
| Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion pleurodesis - Pleural Effusion, Malignant | Phase 4 | Completed | Grupo de Pesquisa em Pleura e Oncologia Toracica | 60 | 2010-01-01 | 2014-05-13 |
| Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter Standard Drainage Instructions, Aggressive Drainage Instructions - Pleural Effusion, Malignant | Phase 4 | Completed | Duke University | 150 | 2009-08-01 | 2013-12-30 |
| Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion Videothoracoscopic talc poudrage (VT)., Talc slurry through a chest tube (DT). - Recurrent Malignant Pleural Effusion. | Phase 4 | Completed | University of Sao Paulo | 60 | 2005-01-01 | 2008-11-11 |
| Non-small Cell Lung Cancer Registry zoledronic acid - Non-Small-Cell Lung Cancer, Pleural Effusion, Malignant | Phase 4 | Completed | Novartis Pharmaceuticals | 300 | 2004-11-01 | 2009-11-23 |
| Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema Intrapleurally Alteplase vs Intrapleurally Urokinase - Empyema, Pleural, Pleural Effusion | Phase 4 | Completed | Hospital Universitari Vall d'Hebron Research Institute | 204 | 2003-12-01 | 2011-07-18 |
Pleural Effusion, Malignant (9) · Empyema, Pleural (4) · Lung Neoplasms (3) · Pleural Diseases (3) · Pneumothorax (3) · Empyema (2) · Pleural Neoplasms (2) · Respiratory Aspiration (2) · Bronchiolitis Obliterans Syndrome (1) · Carcinoma, Non-Small-Cell Lung (1) · Dengue (1) · Hemothorax (1) · Inflammation (1) · Lung Diseases (1)
Respiratory Tract Diseases (19) · Pleural Diseases (16) · Neoplasms (12) · Neoplasms by Site (12) · Respiratory Tract Neoplasms (11) · Thoracic Neoplasms (11) · Pleural Neoplasms (8) · Infections (6) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Respiratory Tract Infections (5) · Suppuration (5) · Inflammation (4) · Lung Diseases (4)
Sodium Chloride (2) · Anesthesia, General (1) · Cefazolin (1) · Clindamycin (1) · Deoxyribonucleases (1) · Diclofenac (1) · Doxycycline (1) · Fentanyl (1) · Ketotifen (1) · Lidocaine (1) · Mesna (1) · One-Lung Ventilation (1) · Pleurodesis (1) · Povidone-Iodine (1) · Prilocaine (1)
Assiut University (3) · Duke University (2) · Catholic University of the Sacred Heart (1) · Grupo de Pesquisa em Pleura e Oncologia Toracica (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · M.D. Anderson Cancer Center (1) · Memorial Healthcare System (1) · Mohamed Reda Ashour (1) · Mohamed Sabry (1) · National University Hospital, Singapore (1) · Novartis Pharmaceuticals (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Prisma Health-Midlands (1) · University of North Carolina, Chapel Hill (1) · University of Sao Paulo (1)
United States (7) · Egypt (3) · Brazil (2) · India (1) · Italy (1) · Singapore (1) · Spain (1)
Ahmed F Koraitim, MD (1) · Ashley L St John (1) · David Ost, MD (1) · Hany H El Sayed, Professor (1) · Jason Akulian, MD, MPH (1) · Jonathan T Puchalski, MD, MEd (1) · L. Lacerna, MD (1) · Mark Block, MD (1) · Momen Wahidi, MD, MBA (1) · Paul A Tambyah (1) · Ricardo M Terra, MD, PhD (1) · Ricardo M. Terra, MD (1) · Rohan Mankikar, MD (1) · Safaa A Eid, MD (1)