14 completed, 6 terminated, 5 withdrawn, 1 recruiting. 17 Phase 2, 5 Phase 3, 3 Phase 4, 2 Early Phase 1, 1 Not applicable.
Follow Nitrogen: new trials by email Literature Review of Nitrogen trials Research Report on Nitrogen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nitrous Oxide for PTSD Nitrous Oxide, Midazolam, Nitrogen - PTSD | Phase 2 | Terminated | VA Office of Research and Development | 1 | 2021-10-07 | 2023-03-03 |
| S-Nitrosylation Therapy of COVID-19 SNO, Nitrogen gas - SARS-CoV2 Infection, Covid19 | Early Phase 1 | Withdrawn | James Reynolds | 2021-08-05 | 2025-05-07 | |
| Efficacy of Nitrous Oxide in OCD: Pilot Study Nitrous Oxide, Nitrogen - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 45 | 2021-04-17 | 2025-08-27 |
| iNOPulse for COVID-19 Inhaled nitric oxide (iNO), Nitrogen gas, Oxygen gas - COVID-19, Hypoxemia | Phase 2 | Withdrawn | Roger Alvarez | 2020-12-01 | 2020-08-19 | |
| Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder Xenon, Nitrogen gas - Major Depressive Disorder, Bipolar Depression | Early Phase 1 | Completed | Massachusetts General Hospital | 13 | 2019-12-05 | 2026-10-09 |
| Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients Nitrogen Gas for Inhalation, Blood withdrawal, Nitric Oxide - Cardiovascular Diseases, Oxidative Stress | Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-07-25 | 2025-12-02 | |
| Study of PAH Subjects With LTOT Use That Have Demonstrated Improved Exercise Tolerance With the Use of Inhaled Nitric Placebo, iNO - Pulmonary Arterial Hypertension | Phase 3 | Withdrawn | Bellerophon Pulse Technologies | 2018-08-01 | 2023-02-21 | |
| Inhaled Gaseous Nitric Oxide (gNO) Antimicrobial Treatment of Difficult Bacterial and Viral Lung (COVID-19) Infections Nitric Oxide 0.5 % / Nitrogen 99.5 % Gas for Inhalation - Respiratory Tract Infections, Corona Virus Infection | Phase 2 | Terminated | Chris Miller | 13 | 2017-10-24 | 2021-07-16 |
| Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest Nitric Oxide, Nitrogen - Heart Arrest, Out-Of-Hospital | Phase 2 | Terminated | Cameron Dezfulian | 57 | 2017-08-26 | 2022-04-25 |
| EMONO for the Treatment of Peripheral Neuropathic Pain Medical Air, EMONO - Neuralgia | Phase 2 | Completed | Air Liquide Santé International | 287 | 2016-11-01 | 2018-09-21 |
| Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure Inhaled nitric oxide, Nitrogen Gas, Crossover iNO - Persistent Fetal Circulation Syndrome, Hypertension, Pulmonary, of Newborn, Persistent | Phase 4 | Withdrawn | University of Florida | 2016-05-01 | 2020-01-07 | |
| Nitrous Oxide as Treatment for Major Depression - a Pilot Study Nitrous Oxide, Placebo - Depression, Major Depressive Disorder | Phase 2 | Completed | Washington University School of Medicine | 21 | 2012-11-01 | 2020-01-27 |
| Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics Sevoflurane/oxygen/air/nitrous oxide - Hypertension | Phase 4 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 80 | 2012-07-01 | 2017-08-23 |
| Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children inhaled nitric oxide, Placebo - Malaria, Cerebral | Phase 2 | Completed | Epicentre | 92 | 2011-09-01 | 2016-03-02 |
| Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation iNO, Nitrogen - Respiratory Distress Syndrome in Premature Infants, Very Low Birth Weight Baby | Not applicable | Completed | University of Oklahoma | 33 | 2011-04-01 | 2020-08-19 |
| Trial of Inhaled Nitric Oxide (iNO) on Ischemia / Reperfusion Injury During Orthotopic Liver Transplantation With Marginal Grafts Inhaled Nitric Oxide (iNO), Placebo Arm (Nitrogen) - Liver Transplant | Phase 2 | Completed | Baylor Research Institute | 23 | 2010-07-01 | 2026-01-28 |
| Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants Inhaled Nitric Oxide, Placebo - Bronchopulmonary Dysplasia | Phase 3 | Completed | Mallinckrodt | 451 | 2009-11-01 | 2017-12-04 |
| Efficacy Study to Evaluate the Effect of Nitric Oxide on the Treatment of Tinea Pedis (Athlete's Foot) Nitric Oxide, Nitrogen - Tinea | Phase 2 | Completed | Nitric BioTherapeutics, Inc | 50 | 2008-12-01 | 2010-02-03 |
| Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation inhaled nitric oxide, nitrogen gas - Reperfusion Injury, Liver Injury | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 80 | 2008-04-01 | 2014-11-06 |
| Use of 50% Nitrous Oxide / 50% Oxygen Premix During Liver Biopsy of Focal Lesion Kalinox 170 bar, Mix of 50% oxygen and 50% nitrogen - Liver Biopsy | Phase 4 | Completed | Air Liquide Santé International | 94 | 2007-10-01 | 2025-03-13 |
Showing 20 of 27. Sign in to see all of them.
COVID-19 (3) · Respiratory Insufficiency (3) · Bronchopulmonary Dysplasia (2) · Depressive Disorder, Major (2) · Hypoxia (2) · Bipolar Disorder (1) · Cardiovascular Diseases (1) · Colorectal Neoplasms (1) · Coronavirus Infections (1) · Cystic Fibrosis (1) · Depression (1) · Dyspnea (1) · Heart Diseases (1) · Heart Failure (1) · Hypertension (1)
Mallinckrodt (6) · Air Liquide Santé International (2) · Massachusetts General Hospital (2) · Baylor Research Institute (1) · Bellerophon Pulse Technologies (1) · Cameron Dezfulian (1) · Chris Miller (1) · Epicentre (1) · James Reynolds (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Nitric BioTherapeutics, Inc (1) · Roger Alvarez (1) · Stanford University (1) · The Cleveland Clinic (1) · University of Alabama at Birmingham (1)
United States (20) · Canada (7) · Belgium (2) · France (2) · Germany (2) · United Kingdom (2) · Austria (1) · Poland (1) · Spain (1) · Uganda (1)
James Baldassarre, MD (4) · Andrew Nierenberg, MD (1) · Ashika Ahmed, MD (1) · Blair Smith, MD (1) · Cameron Dezfulian, MD (1) · Carolyn I Rodriguez, MD PhD (1) · Catalina Bazacliu, MD (1) · Clark Cross, MD (1) · Craig J Railton, MD, PhD (1) · Daniel I Sessler, M.D. (1) · Devin E Eckhoff, MD (1) · Didier Bouhassira, MD (1) · Edith Fleischmann, M.D. (1) · Jeremy D Road, MD (1) · John D Lang, MD (1)
PMID 19192300, PMID 21511500, PMID 24533048, PMID 25063725, PMID 28973344, PMID 33044394, PMID 33769417, PMID 35050957, PMID 37585253
I01CX001789 (1), P50HL084923 (1)