13 completed, 4 terminated, 2 unknown, 2 withdrawn. 8 Not applicable, 6 Phase 2, 4 Phase 3, 3 Phase 1, 1 Early Phase 1.
Follow Periventricular Leukomalacia: new trials by email Literature Review of Periventricular Leukomalacia trials Research Report on Periventricular Leukomalacia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Neonatal White Matter Injury Trial (WRAP) Clemastine fumarate - White Matter Injury, Brain Injury, Fetus and Neonate | Phase 1 | Recruiting | Bridget LaMonica Ostrem, M.D., Ph.D. | 24 | 2026-07-26 | 2026-07-28 |
| Intelligent Physiological Monitoring to Predict Preterm Brain Injury EEG, NIRS - Cerebral Palsy (CP), Intraventricular Hemorrhage Neonatal | Enrolling by invitation | University College Cork | 413 | 2026-04-13 | 2026-10-19 | |
| PUFAs in Preterm Infants Necrotizing Enterocolitis, Intraventricular Hemorrhage | Unknown | The First Hospital of Jilin University | 600 | 2023-09-21 | 2023-09-21 | |
| Spinal Stimulation and Mobility Devices Mobility Device, Spinal Stimulation - Cerebral Palsy, Stroke | Not applicable | Completed | University of Washington | 10 | 2022-08-04 | 2026-09-18 |
| A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy UDI-001 - Cerebral Palsy, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2021-06-02 | 2025-04-06 |
| Sonographic QUantification of Venous Circulation In the Preterm Brain Doppler Ultrasound of venous cerebral circulation - Prematurity; Extreme, Cerebral Circulatory Failure | Not applicable | Completed | Universitair Ziekenhuis Brussel | 47 | 2021-01-01 | 2024-05-17 |
| Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill Baby treadmill, Physical rehabilitation training - Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia | Not applicable | Withdrawn | Children's Hospital of Fudan University | 2020-12-01 | 2023-12-29 | |
| Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill Baby treadmill, Conventional physical rehabilitation training - Hypoxic-Ischemic Encephalopathy, Periventricular Leukomalacia | Not applicable | Terminated | Children's Hospital of Fudan University | 20 | 2020-12-01 | 2023-12-29 |
| Randomized Controlled Trial of Early Intensive Leg Exercise to Improve Walking in Children With Diplegia Intensive exercise - Spastic Diplegia, Periventricular Leukomalacia | Not applicable | Active not recruiting | University of Alberta | 60 | 2019-01-28 | 2026-05-06 |
| Single-session tDCS in Cerebral Palsy Active tDCS, Sham tDCS - Cerebral Palsy, Perinatal Stroke | Not applicable | Completed | University of Minnesota | 20 | 2018-05-01 | 2021-04-13 |
| MISA to NRDS：a Multicenter Study in China Minimal Invasive surfactant administration - Bronchopulmonary Dysplasia, Patent Ductus Arteriosus | Not applicable | Completed | Peking University Third Hospital | 237 | 2017-07-01 | 2019-09-06 |
| Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Erythropoietin, Normal saline - Premature Infants, Intracranial Hemorrhages | Phase 3 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 400 | 2017-04-10 | 2017-10-02 |
| Antibiotic "Dysbiosis" in Preterm Infants Antibiotic, Gastric fluid, Breast milk - Enterocolitis, Necrotizing, Bacteremia | Phase 2 | Completed | University of Florida | 98 | 2017-01-16 | 2024-06-05 |
| Prediction of Brain Injury in Premature Infants Brain Monitoring Platform - Intraventricular Hemorrhage, Periventricular Leukomalacia | Completed | Baylor College of Medicine | 70 | 2016-08-11 | 2026-07-01 | |
| Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Indomethacin, delay in umbilical cord clamp at birth, placebo infusion - Intraventricular Hemorrhage, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Hong Huang | 256 | 2014-08-01 | 2021-11-23 |
| Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Cluster B CogMed: an home-based and computer-based solution to improve working memory deficit, Cluster A No training. Delay start of CogMed - Periventricular Leukomalacia | Not applicable | Completed | IRCCS Fondazione Stella Maris | 20 | 2014-03-01 | 2016-02-24 |
| Inhaled Nitric Oxide and Neuroprotection in Premature Infants inhaled nitric oxide, oxygen - Prematurity, Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Terminated | University of Chicago | 273 | 2008-05-01 | 2024-10-17 |
| High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Erythropoietin, Saline placebo - Infant, Premature, Erythropoietin | Phase 2 | Terminated | Atlantic Health System | 22 | 2007-07-01 | 2013-07-30 |
| Does Erythropoietin Improve Outcome in Very Preterm Infants? Recombinant human Erythropoietin, saline - Intracranial Hemorrhage, Periventricular Leukomalacia | Phase 2 | Completed | Swiss Neonatal Network | 420 | 2006-01-01 | 2018-10-30 |
Showing 20 of 24. Sign in to see all of them.
Leukomalacia, Periventricular (24) · Premature Birth (11) · Cerebral Palsy (8) · Bronchopulmonary Dysplasia (5) · Hypoxia-Ischemia, Brain (5) · Brain Injuries (4) · Enterocolitis, Necrotizing (3) · Intracranial Hemorrhages (3) · Cerebral Infarction (2) · Ductus Arteriosus, Patent (2) · Hypoglycemia (2) · Kernicterus (2) · Sepsis (2) · Abruptio Placentae (1) · Asphyxia Neonatorum (1)
Brain Diseases (24) · Cardiovascular Diseases (24) · Central Nervous System Diseases (24) · Cerebrovascular Disorders (24) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Encephalomalacia (24) · Infant, Newborn, Diseases (24) · Infant, Premature, Diseases (24) · Nervous System Diseases (24) · Vascular Diseases (24) · Female Urogenital Diseases and Pregnancy Complications (11) · Obstetric Labor Complications (11) · Obstetric Labor, Premature (11) · Pathological Conditions, Signs and Symptoms (11) · Pregnancy Complications (11)
Erythropoietin (2) · Sodium Chloride (2) · Ampicillin (1) · Anti-Bacterial Agents (1) · Cefotaxime (1) · Clemastine (1) · Electroencephalography (1) · Gentamicins (1) · Indomethacin (1) · Magnesium (1) · Magnesium Sulfate (1) · Milk, Human (1) · Oxygen (1) · Saline Solution (1) · Spinal Cord Stimulation (1)
Children's Hospital of Fudan University (2) · Atlantic Health System (1) · Baylor College of Medicine (1) · Bridget LaMonica Ostrem, M.D., Ph.D. (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Hong Huang (1) · IRCCS Fondazione Stella Maris (1) · Johns Hopkins University (1) · MGAM LLC (1) · Oswaldo Cruz Foundation (1) · Peking University Third Hospital (1) · Rohto Pharmaceutical Co., Ltd. (1) · Swiss Neonatal Network (1) · The First Hospital of Jilin University (1) · The George Washington University Biostatistics Center (1)
United States (10) · China (4) · Belgium (1) · Brazil (1) · Canada (1) · France (1) · Ireland (1) · Italy (1) · Japan (1) · Switzerland (1)
Bridget Ostrem, MD, PhD (1) · Christopher J. Rhee, MD (1) · Dwight Rouse, MD (1) · Ernest M Graham, M.D. (1) · Eugene Dempsey, Professor (1) · Giovanni Gioni, MD (1) · Hans U Bucher, Prof (1) · Hong Huang, MD-PhD (1) · Jacques Benichou, MD-PhD (1) · Jaynie Yang, Phd (1) · John Bauer, PhD (1) · Josef Neu, MD (1) · Katherine Steele, PHD (1) · Leticia Krauss-Silva, MD, Ph.D (1) · Menachem Miodovnik (1)
PMID 25157725, PMID 25534356, PMID 27187300, PMID 18676556, PMID 18753646, PMID 19622997, PMID 20027029, PMID 20591191, PMID 22059409, PMID 22776958, PMID 24012586, PMID 24136687, PMID 24837863, PMID 24969309, PMID 25123212, PMID 25644966, PMID 25782975, PMID 25863661, PMID 26254839, PMID 26828941, PMID 27130143, PMID 27244862, PMID 31143877, PMID 33479274, PMID 36477478, PMID 37308133, PMID 39373498
1DP2NS148743-01 (1), K01HD078484 (1), K23NS091382 (1), P2CHD086844 (1), R01HD070792 (1), R21HD088005 (1), U10HD021410 (1), U10HD021414 (1), U10HD027860 (1), U10HD027861 (1), U10HD027869 (1), U10HD027905 (1), U10HD027915 (1), U10HD027917 (1), U10HD034116 (1)