2 completed, 1 recruiting. 3 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 2, Recruiting 1 |
| Phase 2 | 2 | Completed 2 |
Follow Periventricular Leukomalacia: new trials by email Literature Review of Periventricular Leukomalacia trials Research Report on Periventricular Leukomalacia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neonatal White Matter Injury Trial (WRAP) Clemastine fumarate - White Matter Injury, Brain Injury, Fetus and Neonate | Phase 1 | Recruiting | Bridget LaMonica Ostrem, M.D., Ph.D. | 24 | 2026-07-26 | 2026-07-28 |
| A Study to Investigate the Safety and Efficacy of UC-MSCs in Pediatric Patients With Cerebral Palsy UDI-001 - Cerebral Palsy, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Rohto Pharmaceutical Co., Ltd. | 6 | 2021-06-02 | 2025-04-06 |
| Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Indomethacin, delay in umbilical cord clamp at birth, placebo infusion - Intraventricular Hemorrhage, Periventricular Leukomalacia | Phase 1 / Phase 2 | Completed | Hong Huang | 256 | 2014-08-01 | 2021-11-23 |
Leukomalacia, Periventricular (3) · Brain Injuries (2) · Cerebral Palsy (1) · Premature Birth (1)
Brain Diseases (3) · Cardiovascular Diseases (3) · Central Nervous System Diseases (3) · Cerebrovascular Disorders (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Encephalomalacia (3) · Infant, Newborn, Diseases (3) · Infant, Premature, Diseases (3) · Nervous System Diseases (3) · Vascular Diseases (3) · Craniocerebral Trauma (2) · Trauma, Nervous System (2) · Wounds and Injuries (2) · Brain Damage, Chronic (1) · Female Urogenital Diseases and Pregnancy Complications (1)
Clemastine (1) · Indomethacin (1)
Bridget LaMonica Ostrem, M.D., Ph.D. (1) · Hong Huang (1) · Rohto Pharmaceutical Co., Ltd. (1)
United States (2) · Japan (1)
Bridget Ostrem, MD, PhD (1) · Hong Huang, MD-PhD (1) · John Bauer, PhD (1) · Sumito Okawa (1) · Vicki Whitehead, RN (1)
1DP2NS148743-01 (1), R01HD070792 (1)