811 completed, 172 unknown, 88 terminated, 71 recruiting. 385 Not applicable, 241 Phase 2, 167 Phase 1, 128 Phase 3, 71 Phase 4.
Follow Parkinson's Disease: new trials by email Literature Review of Parkinson's Disease trials Research Report on Parkinson's Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety, Tolerability and Efficacy of MT101-5 in Subjects With Early Parkinson's Disease MT101-5 - Parkinson's Disease | Phase 2 | Not yet recruiting | Mthera Pharma Co., Ltd. | 120 | 2027-09-01 | 2026-10-16 |
| Gastrointestinal Dopamine Decarboxylase and Levodopa Pharmacokinetics Levodopa (L-dopa) - Parkinson's Disease | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 40 | 2027-07-01 | 2026-08-28 |
| Utilization of Aerobic Exercise to Maintain Neurologic Health Aerobic Exercise - Parkinson's Disease | Not applicable | Not yet recruiting | The Cleveland Clinic | 100 | 2026-12-15 | 2026-10-20 |
| Cognition and Affective Research in China Neurodegenerative Disease, Dementia | Not yet recruiting | Xuanwu Hospital, Beijing | 3000 | 2026-10-01 | 2026-09-22 | |
| Prevent Cognitive Decline in GBA-associated Parkinson's Disease Prasinezumab, Sodium Chloride - Parkinson's Disease | Phase 2 | Recruiting | University Hospital Tuebingen | 120 | 2026-10-01 | 2026-10-23 |
| Study to Test Effects and Safety of RO7568282 in Early Parkinson's Disease RO7568282, Placebo - Parkinson's Disease | Phase 1 / Phase 2 | Not yet recruiting | Hoffmann-La Roche | 474 | 2026-09-30 | 2026-10-20 |
| RESvEraTrol in Parkinson's Disease (RESET) Trans-Resveratrol - Parkinson's Disease | Phase 2 | Recruiting | Georgetown University | 30 | 2026-09-17 | 2026-09-18 |
| Segmental Laser Acupuncture for Constipation and Sleep in Patients With Parkinson's Disease TI-816-3E3 Portable Laser Phototherapy Device, TI-816-3E3 Portable Laser Phototherapy Device - Sham (0 J/cm²) - Parkinson's Disease | Not applicable | Not yet recruiting | China Medical University Hospital | 60 | 2026-09-01 | 2026-08-27 |
| Fecal Microbiota Transplantation in Parkinson's Disease. Fecal microbiota transplantation, Not received Fecal microbiota transplantation - Parkinson's Disease | Not applicable | Not yet recruiting | Chang Gung Memorial Hospital | 58 | 2026-09-01 | 2026-05-19 |
| Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device. Structured wellness care, Wearable brain-computer interface devices, Stem Cell Therapy - Experimental - Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline | Early Phase 1 | Not yet recruiting | Noah Tech, Corp. | 600 | 2026-09-01 | 2026-03-10 |
| Real-world Patient Experiences With Inbrija® Levodopa inhalation powder - Parkinson Disease (PD), Parkinson's Disease | Recruiting | Merz Therapeutics GmbH | 120 | 2026-09-01 | 2026-10-02 | |
| VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism Multimodal visuospatial and topographical memory assessment - Parkinson's Disease, Parkinsonism | Not yet recruiting | IRCCS San Raffaele Roma | 80 | 2026-09-01 | 2026-09-18 | |
| Terazosin And Metabolic Engagement in Parkinson's Disease Terazosin Hydrochloride, Placebo - Parkinson's Disease | Phase 1 / Phase 2 | Withdrawn | Nandakumar Narayanan | 2026-09-01 | 2026-10-07 | |
| Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients Sham Temporal Interference Stimulation, Real Temporal Interference Stimulation - Parkinson's Disease, Movement Disorders | Not applicable | Not yet recruiting | YangPan | 50 | 2026-08-19 | 2026-06-10 |
| Effects of Lemborexant on Motor-sleep Comorbidity in Parkinson's Disease Lemborexant, placebo - Parkinson's Disease, Insomnia | Phase 4 | Not yet recruiting | YangPan | 44 | 2026-08-19 | 2026-06-11 |
| NAD Supplementation in Parkinson's Disease Nicotinamide Riboside (NR), Oral placebo capsules - Parkinson's Disease | Not applicable | Enrolling by invitation | University of Oklahoma | 40 | 2026-08-10 | 2026-08-12 |
| Phase I/II Clinical Trial of UX-DA003 Injection for the Treatment of Patients With Parkinson's Disease UX-DA003 - Parkinson's Disease | Phase 1 / Phase 2 | Not yet recruiting | Shanghai UniXell Biotechnology Co., Ltd | 12 | 2026-08-03 | 2026-07-29 |
| Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants Earlier Within Advanced Parkinson Disease Parkinson's Disease | Recruiting | AbbVie | 100 | 2026-08-03 | 2026-09-01 | |
| An Unblinded, Single Arm, Pilot Observational Study to Test the Safety, Tolerability, Immunogenicity and the Biological Effects of TRB-001 Vaccination. TRB-001 - Parkinson's Disease | Phase 1 | Recruiting | Tridem Bioscience FlexCo | 6 | 2026-07-28 | 2026-09-10 |
| A Trial Investigating Lu AF28996 in Adults With Parkinson's Disease Who Have Motor Fluctuations Lu AF28996, Placebo - Parkinson's Disease | Phase 2 | Recruiting | H. Lundbeck A/S | 150 | 2026-07-28 | 2026-09-08 |
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Parkinson Disease (1249) · Dyskinesias (53) · Motor Activity (38) · Depression (33) · Movement Disorders (31) · Parkinsonian Disorders (31) · Cognitive Dysfunction (30) · Essential Tremor (30) · Multiple System Atrophy (25) · Alzheimer Disease (23) · Tremor (22) · Dementia (19) · Neurodegenerative Diseases (19) · Dystonia (16) · Supranuclear Palsy, Progressive (15)
Synucleinopathies (1246) · Brain Diseases (1244) · Central Nervous System Diseases (1244) · Basal Ganglia Diseases (1243) · Nervous System Diseases (1242) · Neurodegenerative Diseases (1230) · Movement Disorders (1218) · Parkinsonian Disorders (1218) · Pathological Conditions, Signs and Symptoms (219) · Signs and Symptoms (184) · Neurologic Manifestations (149) · Mental Disorders (120) · Behavior (83) · Neurocognitive Disorders (67) · Pathologic Processes (41)
Levodopa (42) · carbidopa, levodopa drug combination (35) · rasagiline (31) · Deep Brain Stimulation (30) · rotigotine (20) · Exercise (18) · Carbidopa (17) · istradefylline (17) · Apomorphine (13) · Stalevo (12) · Sugars (12) · Transcranial Magnetic Stimulation (11) · entacapone (11) · perampanel (11) · Amantadine (8)
VA Office of Research and Development (31) · National Institute of Neurological Disorders and Stroke (NINDS) (26) · Oregon Health and Science University (23) · Kyowa Kirin Co., Ltd. (17) · University Hospital, Clermont-Ferrand (16) · UCB Pharma (15) · Bial - Portela C S.A. (14) · NeuroDerm Ltd. (12) · Teva Branded Pharmaceutical Products R&D, Inc. (12) · University of Florida (12) · Great Lakes NeuroTechnologies Inc. (11) · Institut National de la Santé Et de la Recherche Médicale, France (11) · Radboud University Medical Center (11) · AbbVie (10) · Eisai Inc. (9)
United States (573) · France (132) · Germany (82) · United Kingdom (79) · China (72) · Canada (70) · Italy (55) · Israel (47) · Spain (44) · Netherlands (35) · Japan (32) · Austria (27) · Taiwan (26) · Poland (21) · Portugal (19)
Neil Sussman, MD (7) · Giuseppe Frazzitta, MD (6) · Kyoji Imaoka, Mr (6) · Francisco A Ponce, MD (5) · David Devos, MD, PhD (4) · David W Sparrow, DSc (4) · Dustin A Heldman, PhD (4)
PMID 36602886, PMID 38588457, PMID 30741694, PMID 31127735, PMID 31356217, PMID 10816186, PMID 12112073, PMID 1454205, PMID 16401616, PMID 16436781, PMID 19126811, PMID 20519680, PMID 21484867, PMID 23667214, PMID 23860343, PMID 24251381, PMID 24412048, PMID 25185211, PMID 29913017, PMID 30425824, PMID 38908172, PMID 40680102, PMID 41626017, PMID 8080242, PMID 8938817, PMID 9444566, PMID 10435499, PMID 11009194, PMID 11035889, PMID 11408093, PMID 11495422, PMID 11533734, PMID 11911234, PMID 12047983, PMID 12222941, PMID 12370870, PMID 12465061, PMID 12707451, PMID 12764050, PMID 12771261, PMID 12785243, PMID 12809998, PMID 12891670, PMID 12975291, PMID 1362956, PMID 14638971, PMID 15097290, PMID 15184637, PMID 15300651, PMID 15451225
2008 (6), 2009 (6), 2014 (6), 2004 (5), 2016 (4), 2005 (2), 2018 (2), 2019 (2), 2025 (2), K23NS080912 (2), R01NS021062 (2), R01NS052318 (2), R44AG044293 (2), U01NS043128 (2), 1UH3NS113769 (1)