Post-Acute COVID-19 Syndrome: Clinical Trials

269 completed, 116 unknown, 105 recruiting, 38 active not recruiting. 283 Not applicable, 92 Phase 2, 33 Phase 3, 14 Phase 1, 9 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	283	Completed 134, Unknown 53, Recruiting 47, Active not recruiting 19, Not yet recruiting 15, Withdrawn 6, Enrolling by invitation 3, Suspended 3, Terminated 3
Phase 2	92	Completed 45, Recruiting 16, Unknown 9, Active not recruiting 8, Not yet recruiting 6, Terminated 3, Withdrawn 3, Enrolling by invitation 2
Phase 3	33	Completed 13, Recruiting 8, Unknown 5, Active not recruiting 2, Not yet recruiting 2, Enrolling by invitation 1, Terminated 1, Withdrawn 1
Phase 1	14	Unknown 5, Completed 3, Recruiting 3, Not yet recruiting 2, Terminated 1
Phase 4	9	Completed 3, Unknown 3, Recruiting 2, Terminated 1
Early Phase 1	6	Completed 1, Recruiting 1, Suspended 1, Terminated 1, Unknown 1, Withdrawn 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Taurine Supplementation in Adolescents With Post-COVID Condition Taurine - Long COVID, Post COVID-19 Condition	Phase 1 / Phase 2	Not yet recruiting	University of Alberta	30	2026-12-30	2026-10-16
CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID)	Phase 2	Not yet recruiting	Charite University, Berlin, Germany	38	2026-12-01	2026-07-24
Fatigue in Long COVID Lightning Process, Activity Pacing - Long COVID	Not applicable	Not yet recruiting	McMaster University	100	2026-11-01	2026-07-13
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I) Keytruda - Post-Acute COVID-19 Syndrome	Phase 1	Not yet recruiting	National Institute of Neurological Disorders and Stroke (NINDS)	15	2026-10-28	2026-10-23
Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE) Aripiprazole (low-dose, 1mg), Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID-19 Condition (PCC or Long COVID)	Phase 2	Not yet recruiting	Christiana Franke	138	2026-10-01	2026-07-20
Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Cryotherapy - ME/CFS, Fibromyalgia (FM)	Not applicable	Not yet recruiting	Oxford Brookes University	40	2026-10-01	2026-10-14
Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue Transcranial Direct Current Stimulation - Long COVID, Post-COVID Conditions	Not applicable	Not yet recruiting	University of Las Palmas de Gran Canaria	20	2026-09-15	2026-07-22
Epigenetic Changes in Long COVID Patients Long COVID-19 Syndrome, Long COVID Symptoms		Not yet recruiting	Istituti Clinici Scientifici Maugeri SpA	1000	2026-09-01	2026-08-11
Five-year Follow-up After Sars-CoV-2 Infection: Prevalence and Evolution of Post-acute Sequalae of COVID-19 (PASC) Post-Acute Sequelae of COVID-19 (PASC) Assessment - Long COVID, COVID-19		Not yet recruiting	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	900	2026-09-01	2026-08-14
Micro-choice-based Intervention for Multicausal Fatigue Micro-choice-based intervention - Multicausal Fatigue, Fatigue	Not applicable	Recruiting	University Hospital, Basel, Switzerland	24	2026-08-13	2026-08-18
Observational Study of Intranasal IVIG in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients Undergoing Medical Tourism Post-Acute Sequelae of SARS-CoV-2 Infection, Long COVID		Not yet recruiting	Tamara C Tamas	50	2026-08-01	2025-12-02
Sauna for Long Covid whole body hyperthermia - Long COVID	Not applicable	Recruiting	Massachusetts General Hospital	21	2026-08-01	2025-11-13
Cognitive Impairment and Return to Work in Long COVID Long COVID		Completed	Hopitaux de Saint-Maurice	55	2026-08-01	2026-10-19
A Pilot Randomized Controlled Trial of Homeopathic Treatment for Long COVID Treatment A: Treatment by a homeopath prescribing a specific homeopathic remedy for long COVID, a course of individually tailored treatment by a homeopath - Long COVID, Long COVID Symptoms	Not applicable	Not yet recruiting	St. Mary's University, Twickenham	120	2026-07-15	2026-07-09
A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID Maraviroc (MVC), Atorvastatin, 10mg, 20mg, 40mg, Placebo, Maraviroc - Long COVID	Phase 2 / Phase 3	Not yet recruiting	HealthBio, Inc.	252	2026-07-15	2026-06-18
SuperCAP Program to Improve Cognition and Daily Functioning in Post-COVID-19 Condition SuperCAP intervention program, Psychoeducational intervention - Post COVID Condition	Not applicable	Recruiting	Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia	100	2026-07-15	2026-09-11
Development of an Accessible Cognitive Behavioral Therapy Digital Therapeutic for Individuals With Long COVID Rauha® Digital Therapeutic Platform (Toivoa-004) - Long Covid, Depression	Not applicable	Withdrawn	Toivoa Inc		2026-07-01	2026-07-29
Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID Diaphragmatic Electrostimulation Using KOTS Currents, Diaphragmatic Breathing Exercises - Long COVID Syndrome, Post-Acute COVID-19 Syndrome	Not applicable	Completed	Universidad Pontificia de Salamanca	9	2026-06-14	2026-09-29
sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19 Fluvoxamine, Placebo - Post-COVID, POST-Covid 19	Phase 3	Recruiting	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	160	2026-06-04	2026-06-09
Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID? Taurine supplementation - Long COVID Syndrome		Recruiting	York University	30	2026-06-01	2026-06-05

Showing 20 of 597. Sign in to see all of them.

Narrower conditions

COVID-19 (202)  ·  Fatigue (60)  ·  Fatigue Syndrome, Chronic (38)  ·  Motor Activity (29)  ·  Mental Fatigue (26)  ·  Cognitive Dysfunction (24)  ·  Depression (19)  ·  Dyspnea (18)  ·  Anxiety Disorders (16)  ·  Postural Orthostatic Tachycardia Syndrome (16)  ·  Coronavirus Infections (12)  ·  Chronic Pain (11)  ·  Psychological Well-Being (11)  ·  Autonomic Nervous System Diseases (9)

Broader conditions

Disease Attributes (597)  ·  Pathologic Processes (597)  ·  Pathological Conditions, Signs and Symptoms (597)  ·  Chronic Disease (596)  ·  Coronaviridae Infections (596)  ·  Nidovirales Infections (596)  ·  Pneumonia (596)  ·  Pneumonia, Viral (596)  ·  RNA Virus Infections (596)  ·  Virus Diseases (596)  ·  Lung Diseases (595)  ·  Post-Infectious Disorders (595)  ·  Respiratory Tract Diseases (595)  ·  Respiratory Tract Infections (594)  ·  Infections (592)

Interventions

Exercise (13)  ·  Rehabilitation (8)  ·  Educational Status (7)  ·  Acupuncture Therapy (6)  ·  Hyperbaric Oxygenation (6)  ·  Saline Solution (6)  ·  nirmatrelvir and ritonavir drug combination (6)  ·  Blood Specimen Collection (5)  ·  Plasmapheresis (5)  ·  Surveys and Questionnaires (5)  ·  Transcranial Direct Current Stimulation (5)  ·  Cognitive Training (4)  ·  Magnetic Resonance Spectroscopy (4)  ·  Ritonavir (4)  ·  Therapeutics (4)

Sponsors

VA Office of Research and Development (11)  ·  Icahn School of Medicine at Mount Sinai (10)  ·  Duke University (8)  ·  Charite University, Berlin, Germany (7)  ·  Karolinska Institutet (6)  ·  Kanecia Obie Zimmerman (5)  ·  Massachusetts General Hospital (5)  ·  University of Alberta (5)  ·  Adhera Health, Inc. (4)  ·  Beth Israel Deaconess Medical Center (4)  ·  Columbia University (4)  ·  Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (4)  ·  Mayo Clinic (4)  ·  Medical University of Vienna (4)  ·  Universitas Indonesia (4)

Countries

United States (193)  ·  Spain (50)  ·  Canada (40)  ·  Germany (40)  ·  Italy (29)  ·  United Kingdom (27)  ·  Brazil (21)  ·  China (15)  ·  France (15)  ·  Netherlands (15)  ·  Austria (14)  ·  Taiwan (14)  ·  Turkey (Türkiye) (11)  ·  Switzerland (10)  ·  Mexico (8)

Top investigators

Lucinda Bateman, MD (6)  ·  Avindra Nath, M.D. (3)  ·  Barry Make, MD (3)  ·  Christina Barkauskas, MD (3)  ·  Cyndya Shibao, MD (3)  ·  Gary M Felker, MD (3)  ·  Janna Friedly, MD, MPH (3)  ·  Kanecia Zimmerman, MD PhD (3)  ·  Pam Taub, MD (3)  ·  Peter Novak, MD (3)  ·  Susan Redline, MD MPH (3)  ·  Tae Chung, MD (3)  ·  Angela M Cheung, MD, PhD (2)  ·  Anna Norweg, PhD (2)  ·  Christopher Grainger, MD (2)

Results publications

PMID 41720282, PMID 42282195, PMID 32784198, PMID 33428867, PMID 34273080, PMID 34308300, PMID 39356507, PMID 10377201, PMID 12668799, PMID 14715035, PMID 15023839, PMID 16314677, PMID 17786266, PMID 18258905, PMID 19568835, PMID 20590838, PMID 22100537, PMID 23875929, PMID 24012996, PMID 24790712, PMID 26320841, PMID 27856631, PMID 27993601, PMID 28106111, PMID 29034226, PMID 29128354, PMID 30867063, PMID 31004219, PMID 31475544, PMID 31985934, PMID 31986264, PMID 32022836, PMID 32052466, PMID 32087334, PMID 32112977, PMID 32253535, PMID 32283155, PMID 32352407, PMID 32383624, PMID 32427134, PMID 32475821, PMID 32541352, PMID 32587887, PMID 32629042, PMID 32637987, PMID 32644129, PMID 32658591, PMID 32700055, PMID 32710297, PMID 32859477

NIH funding

OT2HL156812 (3), 2025 (2), 1OT2HL156812-01 (1), 2023 (1), 272201800011C-P00005-9999-1 (1), 3UM1AI068614-14S1 (1), I01CX002668 (1), I01RX004572 (1), I21RX004092 (1), I21RX004409 (1), P30AG067988 (1), R01AG085873 (1), R01AG089307 (1), R01AI185685 (1), R01DC021179 (1)