12 completed, 3 recruiting, 2 terminated, 2 unknown. 13 Not applicable, 5 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 7, Recruiting 2, Terminated 2, Active not recruiting 1, Unknown 1 |
| Phase 4 | 5 | Completed 4, Unknown 1 |
| Phase 1 | 1 | Suspended 1 |
Follow this drug Literature Review of Lower Body Negative Pressure trials Research Report on Lower Body Negative Pressure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Intra-Abdominal Pressure During Gynecologic Laparoscopy abdominal pressure - Gynecologic Surgical Procedures | Not applicable | Terminated | Nassau University Medical Center | 37 | 2025-11-23 | 2026-07-22 |
| Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension Lower body negative pressure - Parkinson Disease, Orthostatic Hypotension | Not yet recruiting | Centre Hospitalier Universitaire Vaudois | 130 | 2025-10-01 | 2025-08-24 | |
| Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac Unloading LBNP, LBNP + Isometric handgrip exercise - Orthostatic Intolerance | Not applicable | Recruiting | Tracy Baynard | 64 | 2025-05-01 | 2026-04-30 |
| Acetated Ringer´s Solution in Experimental Hypovolemia Ringer acetate, Lower body negative pressure - Hypovolemia, Fluid Loss | Phase 4 | Completed | Oslo University Hospital | 15 | 2024-03-02 | 2026-06-02 |
| Impact of Gravity on Cardiac Hemodynamics Cardiovascular and Baroreflex stimulation by Tilting, Cardiovascular and Baroreflex stimulation by Lower Body Negative Pressure - Diabetes type1, Healthy | Not applicable | Completed | University Hospital, Caen | 30 | 2023-11-22 | 2026-06-25 |
| Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction Lower-body Negative Pressure (-25 mmHg), Lower-body Negative Pressure (-15 mmHg), Lower-body Neutral Pressure (0 mmHg) - Heart Failure With Preserved Ejection Fraction | Not applicable | Recruiting | University of British Columbia | 60 | 2023-01-25 | 2025-04-04 |
| fMRI in Postural Tachycardia Syndrome Lower Body Negative Pressure, Sham Pressure - Postural Tachycardia Syndrome | Not applicable | Active not recruiting | Milton S. Hershey Medical Center | 21 | 2022-02-18 | 2026-09-24 |
| Physiological Validation of Current Machine Learning Models for Hemodynamic Instability in Humans Assigned Interventions - Hypotension and Shock | Not applicable | Completed | Mayo Clinic | 100 | 2021-05-12 | 2023-05-31 |
| Methoxyflurane and Fentanyl in LBNP Lower body negative pressure (LBNP) - Hypovolemia, Cardiac Output, Low | Phase 4 | Completed | Oslo University Hospital | 15 | 2020-11-18 | 2022-06-30 |
| The Influence of LMA Cuff Pressure on Gastric Insufflation Assessed by Ultrasound in Pediatric Patient lower pressure, higher pressure - Aspiration | Not applicable | Unknown | Seoul National University Hospital | 230 | 2020-08-10 | 2020-08-04 |
| Countermeasures for Visual Impairment in Astronauts Lower body negative pressure - Space Flight Associated Neuro-ocular Syndrome | Not applicable | Completed | University of Texas Southwestern Medical Center | 10 | 2019-03-01 | 2021-09-08 |
| Measurement of Hemodynamic Responses to Lower Body Negative Pressure Lower body negative pressure - Hypotension and Shock | Not applicable | Completed | Mayo Clinic | 24 | 2019-01-08 | 2019-06-12 |
| Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction Estradiol patch, Cetrotide, Fasting - Heart Diseases, Left Ventricular Dysfunction | Phase 4 | Unknown | The University of Texas at Arlington | 100 | 2018-09-13 | 2024-02-20 |
| Blood Flow in Individuals With Down Syndrome Hand grip exercise and lower body negative pressure - Down Syndrome | Not applicable | Terminated | University of Illinois at Chicago | 21 | 2018-03-01 | 2019-07-15 |
| Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia Lower body negative pressure - Hypovolemia, Hemodynamic Instability | Recruiting | Yale University | 120 | 2017-11-15 | 2026-01-20 | |
| Evaluation of the ORTHO-LBNP System Head up tilt (HUT), Lower body negative pressure (LBNP), Head down tilt (HDT) - Orthostatic Hypotension, Ischemia | Not applicable | Completed | Military Institute of Aviation Medicine | 46 | 2017-01-02 | 2026-03-09 |
| Cerebral Oximetry in Lower Body Negative Pressure Lower body negative pressure, Continuous positive airway pressure, Positive expiratory pressure - Hypovolemia | Not applicable | Completed | Oslo University Hospital | 20 | 2015-10-01 | 2017-03-17 |
| Effects of Neuromuscular Blockade Level and Intra-abdominal Pressure on Surgical Conditions and Cardiopulmonary Responses During Laparoscopic Colon Surgery With the Trendelenburg Position Standard abdominal pressure, Low abdominal pressure, Conventional neuromuscular blockade - Cardiac Index | Not applicable | Completed | Seoul National University Hospital | 131 | 2014-09-01 | 2018-08-06 |
| Detection of Hypovolemia Using Pleth Variability Index (PVI) Lower body negative pressure (LBNP) - Hypovolemia | Completed | University Hospital, Linkoeping | 14 | 2011-10-01 | 2013-01-17 | |
| Renal Response to Lower Body Negative Pressure in Pre-hypertensive States Lower body negative pressure (LBNP), Candesartan cilexetil - Hypertension, Obesity | Phase 4 | Completed | PD Dr. Grégoire Wuerzner | 78 | 2009-05-01 | 2017-05-24 |
Showing 20 of 22. Sign in to see all of them.
Hypovolemia (5) · Hypertension (2) · Hypotension (2) · Hypotension, Orthostatic (2) · Motor Activity (2) · Shock (2) · Agnosia (1) · Cardiac Output, Low (1) · Diabetes Mellitus (1) · Down Syndrome (1) · Dyspnea (1) · Fasting (1) · Heart Diseases (1) · Heart Failure (1) · Hypoxia (1)
Oslo University Hospital (3) · Mayo Clinic (2) · Seoul National University Hospital (2) · University of Texas Southwestern Medical Center (2) · Centre Hospitalier Universitaire Vaudois (1) · Military Institute of Aviation Medicine (1) · Milton S. Hershey Medical Center (1) · Nassau University Medical Center (1) · PD Dr. Grégoire Wuerzner (1) · The University of Texas at Arlington (1) · Tracy Baynard (1) · University Hospital, Caen (1) · University Hospital, Linkoeping (1) · University of British Columbia (1) · University of Calgary (1)
United States (10) · Norway (3) · Canada (2) · Switzerland (2) · France (1) · Poland (1) · South Korea (1) · Sweden (1)
Timothy B Curry (2) · Amy Arnold, Ph.D. (1) · Aymen Alian, MD (1) · Benjamin Levine, MD (1) · Gregoire Wuerzner, MD (1) · Jin-Tae Kim, PhD (1) · Lena Nilsson, MD, PhD (1) · Michel Burnier, MD (1) · Neil D Eves, PhD (1) · Petr Itzhak, DO (1) · Robert S Sheldon, MD PhD (1) · Svein Aslak Landsverk, M.D., PhD (1) · Thessa Hilgenkamp, PhD (1) · Wanpen Vongpatanasin, MD (1)
PMID 23547240, PMID 23839074, PMID 29876358, PMID 33073631, PMID 35212554, PMID 37638077, PMID 37824038
K99HD092606 (1), UL1TR002014 (1)