8 completed, 3 recruiting, 1 not yet recruiting, 1 terminated. 4 Not applicable, 3 Phase 3, 1 Early Phase 1, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 4 |
| Phase 3 | 3 | Completed 2, Not yet recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 2 | 1 | Terminated 1 |
Follow Oral Cavity: new trials by email Literature Review of Oral Cavity trials Research Report on Oral Cavity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| APG-157 in Locally Advanced Head and Neck Squamous Cell Carcinoma APG-157, Surgery, Radiation/Chemotherapy - Head and Neck Cancer, Head and Neck (HNSCC) | Phase 3 | Not yet recruiting | Aveta Biomics, Inc. | 826 | 2026-07-01 | 2026-07-01 |
| Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer VRP-encapsulated saRNA encoding IL-12 (1 x 10^9 viral particles per injection), Pembrolizumab (KEYTRUDA®), VRP-encapsulated saRNA encoding IL-12 (3 x 10^8 viral particles per injection) - Head and Neck Cancers- Squamous Cell, Head and Neck Cancer | Phase 1 | Recruiting | VLP Therapeutics | 41 | 2025-05-13 | 2026-09-21 |
| Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for Action tests/questionnaires, biological samples, evaluation - Oropharynx Cancer, Oral Cavity | Recruiting | Centre Hospitalier Universitaire Dijon | 306 | 2024-09-06 | 2026-10-08 | |
| PuraBond® and Pain Following Resection of Oral or Oropharyngeal Mucosal Lesions PuraBond - Pain, Hemorrhage | Not applicable | Completed | University of Liverpool | 73 | 2023-10-16 | 2025-09-16 |
| Oral Health and Fundamental of Care Program OHFCP2 - Oral Hygiene, Oral Health, Oral Cavity | Not applicable | Completed | Alberto Dal Molin | 60 | 2023-05-16 | 2025-01-10 |
| Perioperative Supplementation With Immunonutrition and Its Impact on Surgical Outcome and Pain in Oral Cavity or Mandibular Tumours Standard feeding, Omega 3 and dipeptiven - Immunonutrition, Surgical Outcome | Not applicable | Completed | Cairo University | 176 | 2023-02-01 | 2024-04-02 |
| Spectroscopic Analysis of Tongue Tumor Samples. tongue surgery - Mass Spectroscopy, Molecular Profile | Recruiting | Centre Hospitalier Universitaire, Amiens | 33 | 2021-03-10 | 2026-06-15 | |
| The Effect of Oral Care Protocol on Prevention of Oral Mucositis in Pediatric Cancer Patients Oral care protocol - Mucositis, Pediatric Cancer | Not applicable | Completed | Dokuz Eylul University | 40 | 2019-10-07 | 2020-10-19 |
| Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma Metformin Hydrochloride, Doxycycline, Metformin +Doxycycline - Larynx, LIP | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 7 | 2017-04-03 | 2026-01-29 |
| Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer External Beam Radiation Therapy, Metformin Hydrochloride, Placebo - Larynx, Lip | Early Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 9 | 2017-01-05 | 2025-04-30 |
| The Influence of Bisphosphonates in the Oral Cavity in Children Oral Cavity, Osteomyelitis | Completed | Hadassah Medical Organization | 60 | 2007-03-01 | 2009-01-29 | |
| Post-Operative Adjuvant Concurrent Chemoradiotherapy For High Risk Oral Cavity Squamous Cell Carcinoma Patients cisplatin - Oral Cavity, Squamous Cell Carcinoma | Phase 3 | Completed | National Health Research Institutes, Taiwan | 161 | 1999-10-01 | 2005-09-20 |
| Chemoprevention Study of Oral Cavity Squamous Cell Carcinoma 13-cis Retino Acid - Oral Cavity, Squamous Cell Carcinoma | Phase 3 | Completed | National Health Research Institutes, Taiwan | 342 | 1999-04-01 | 2005-09-20 |
Carcinoma, Squamous Cell (4) · Head and Neck Neoplasms (2) · Laryngeal Diseases (2) · Mouth Neoplasms (2) · Pain (2) · Squamous Cell Carcinoma of Head and Neck (2) · Colonic Neoplasms (1) · Hemorrhage (1) · Liver Neoplasms (1) · Lymphoid Interstitial Pneumonia (1) · Mandibular Neoplasms (1) · Margins of Excision (1) · Mucositis (1) · Neoplasms (1) · Oropharyngeal Neoplasms (1)
Neoplasms (7) · Carcinoma (5) · Neoplasms by Histologic Type (5) · Neoplasms, Glandular and Epithelial (5) · Stomatognathic Diseases (5) · Neoplasms by Site (4) · Neoplasms, Squamous Cell (4) · Mouth Diseases (3) · Otorhinolaryngologic Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Bone Diseases (2) · Digestive System Diseases (2) · Gastrointestinal Diseases (2) · Musculoskeletal Diseases (2) · Neurologic Manifestations (2)
Metformin (2) · CARE protocol (1) · Cisplatin (1) · Docosahexaenoic Acids (1) · Doxycycline (1) · Drug Therapy (1) · Mouthwashes (1) · Radiation (1) · Solutions (1) · Surgical Procedures, Operative (1) · Surveys and Questionnaires (1) · Toothbrushing (1) · alanylglutamine (1) · pembrolizumab (1)
National Health Research Institutes, Taiwan (2) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · Alberto Dal Molin (1) · Aveta Biomics, Inc. (1) · Cairo University (1) · Centre Hospitalier Universitaire Dijon (1) · Centre Hospitalier Universitaire, Amiens (1) · Dokuz Eylul University (1) · Hadassah Medical Organization (1) · University of Liverpool (1) · VLP Therapeutics (1)
United States (3) · France (2) · Taiwan (2) · Egypt (1) · Israel (1) · Italy (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Mow-Ming Hsu, MD (2) · Adam Luginbuhl, MD (1) · Chiara Gallione, PhD, MSN, RN (1) · Cristian Vairo, PhD st, MSN, RN (1) · Fred M Baik, MD (1) · Jennifer Johnson, MD, PhD (1)