31 completed, 19 recruiting, 19 unknown, 12 not yet recruiting. 42 Not applicable, 11 Phase 2, 6 Phase 1, 6 Phase 3, 1 Phase 4.
Follow Margins of Excision: new trials by email Literature Review of Margins of Excision trials Research Report on Margins of Excision
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biomechanical Characterization of Skin Properties Using Impact Based-Analysis Method (IBAM) Melanoma (Skin Cancer), Skin Carcinoma | Not yet recruiting | Centre Hospitalier Universitaire Henri Mondor, Assistance Publique Hôpitaux de Paris | 10 | 2026-12-03 | 2026-10-06 | |
| PIRe 2.0: A Stepped-Care Model for Involving Relatives Across Sectors Supportive Care - Brain Injuries, Acute, Brain Tumor Adult | Not applicable | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 160 | 2026-10-01 | 2026-05-19 |
| Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing Timolol 0.5% Ophthalmic Solution, Hydrogel of placebo - Mohs Micrographic Surgery, Excision Margin | Phase 2 | Not yet recruiting | University of California, Davis | 220 | 2026-10-01 | 2026-08-18 |
| Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD IOUS-guided margin selection - Crohn's Disease (CD) | Not applicable | Recruiting | The Cleveland Clinic | 22 | 2026-09-01 | 2026-08-27 |
| HISMAR: Intraoperative Margin Assessment Using the Histolog® Scanner to Reduce Reoperation in Breast-Conserving Surgery Histolog® Scanner - Breast Cancer, Ductal Carcinoma In Situ | Not applicable | Not yet recruiting | Hôpital du Valais | 228 | 2026-09-01 | 2026-04-14 |
| SPECTRA: Intraoperative Hyperspectral Imaging for Prostate Cancer HyperSpectral imaging acquisition of ex-vivo prostate specimen prior formalin fixation (fresh acquisition).. - Localized Prostate Cancer, Positive Surgical Margin | Not applicable | Recruiting | Massimo Valerio | 26 | 2026-08-01 | 2026-09-17 |
| Individualized Primary Clinical Target Volume Based on Margin Expansion for Nasopharyngeal Carcinoma Comprehensive Therapy Based on Tumor Stage, IMRT with Primary Clinical Target Volume Based on Margin Expansion, IMRT with Consensus Primary Clinical Target Volume - Non-metastatic Nasopharyngeal Carcinoma | Phase 3 | Recruiting | Sun Yat-sen University | 568 | 2026-07-24 | 2026-08-19 |
| Defining the Ablative Dose for Y-90 TARE Yttrium-90 Radiation Segmentectomy (Y90 RS) using glass microspheres - HCC - Hepatocellular Carcinoma | Phase 2 | Recruiting | Northwestern University | 30 | 2026-05-15 | 2026-09-15 |
| Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors Indocyanine Green (ICG) - Squamous Cell Carcinoma Head and Neck Cancer (HNSCC), Margin Assessment | Phase 2 | Recruiting | Medical University of South Carolina | 30 | 2026-05-04 | 2026-07-07 |
| A Study to Evaluate the Performance of Confocal Microscopy to Detect Positive Margins During Radical Prostatectomy LaserSAFE - Prostate Cancer, Prostate Cancer (Adenocarcinoma) | Not applicable | Recruiting | University College, London | 693 | 2026-04-20 | 2026-05-18 |
| Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors EXS74539 - Solid Tumor, Small Cell Lung Cancer (SCLC) | Phase 1 | Recruiting | Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc. | 40 | 2026-04-13 | 2026-06-10 |
| A Novel Intraoperative Fluorescence-guided System for Evaluating Margins During Breast-conserving Surgery for Breast Cancer EndoSCell Scanner (ES Scanner) System - Breast-Conserving Surgery | Not applicable | Recruiting | Guangdong Provincial People's Hospital | 172 | 2026-04-01 | 2026-06-29 |
| A Prospective Clinical Study Investigating the Use of the Histolog Scanner for Intraoperative Assessment of Surgical Margins in Patients Undergoing Breast-conserving Surgery for Histologically Confirmed Breast Cancer. The Histolog Scanner Operates on the Principle of Confocal Microscop Histolog scanner - Breast Cancer | Not yet recruiting | Silesian Hospital in Opava | 20 | 2026-01-20 | 2026-01-14 | |
| Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin Reduction Linear accelerator-based stereotactic radiation for brain metastases using 0mm or 1mm PTV - Brain Metastases, Adult, Brain Tumor - Metastatic | Phase 2 | Recruiting | Ayal A. Aizer, MD | 60 | 2025-12-30 | 2026-09-08 |
| Impact of Preoperative High-Frequency Ultrasound Cutaneous Lesion Extent Assessment on Excision Margin Positivity in Head and Neck Skin Cancer, and the Relationship Between Preoperative Assessment Methods, Inadequate Excision Margins, and Tumor Recurrence High-Frequency Ultrasound, Dermoscopy - Basal Cell Carcinoma of Skin, Cutaneous Squamous Cell Carcinoma (CSCC) | Not yet recruiting | Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji | 400 | 2025-12-23 | 2026-01-23 | |
| Performance of 18F-FDG Micro-PET-CT in the Assessment of Surgical Margins in Head and Neck Cancer micro PET/CT - Head & Neck Cancer | Not applicable | Recruiting | Centre Henri Becquerel | 10 | 2025-11-07 | 2025-12-16 |
| Infiltration Pattern of Locally Advanced ESCC Esophagectomy - Esophageal Squamous Cell Carcinoma (ESCC), Infiltration | Enrolling by invitation | Shanghai Chest Hospital | 30 | 2025-10-01 | 2026-05-05 | |
| Comparative Research on the Accuracy of Margin Interpretation in Breast-Conserving Surgery for Breast Cancer: Cell Microscopic Imaging and Standard Frozen Pathology EndoScell™ intraoperative handheld microscope - Breast-Conserving Surgery, Breast Carcinoma | Not applicable | Not yet recruiting | Peking University Cancer Hospital & Institute | 167 | 2025-07-01 | 2025-06-19 |
| EpCAM-Targeted Surface-Enhanced Raman Spectroscopy Nanotags for Rapid Evaluation of Surgical Margins and Sentinel Lymph Node Metastasis Status in Breast Cancers SERS detection - Sentinel Lymph Node, Breast Cancers | Not yet recruiting | Yunnan Cancer Hospital | 40 | 2025-06-15 | 2025-06-12 | |
| The Comparison of Navigational Bronchoscopic and CT-Guided Preoperative Markings in Minimally Invasive Thoracic Surgery Preoperative marking - VATS, Lung | Not applicable | Completed | Semmelweis University | 66 | 2025-06-01 | 2025-09-05 |
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Breast Neoplasms (17) · Recurrence (9) · Prostatic Neoplasms (8) · Neoplasms (7) · Carcinoma, Squamous Cell (5) · Squamous Cell Carcinoma of Head and Neck (5) · Stomach Neoplasms (5) · Carcinoma, Basal Cell (4) · Carcinoma, Non-Small-Cell Lung (4) · Carcinoma, Renal Cell (4) · Head and Neck Neoplasms (4) · Neoplasm Metastasis (4) · Disease (3) · Glioblastoma (3)
Morphological and Microscopic Findings (92) · Pathological Conditions, Signs and Symptoms (92) · Neoplasms (66) · Neoplasms by Site (64) · Neoplasms by Histologic Type (27) · Skin and Connective Tissue Diseases (26) · Skin Diseases (24) · Neoplasms, Glandular and Epithelial (22) · Pathologic Processes (19) · Breast Diseases (18) · Digestive System Diseases (18) · Carcinoma (17) · Digestive System Neoplasms (15) · Gastrointestinal Diseases (14) · Urogenital Diseases (13)
Dermoscopy (2) · Everolimus (2) · Indocyanine Green (2) · Microscopy, Confocal (2) · Bevacizumab (1) · Chemoradiotherapy (1) · Cysteamine (1) · Drug Combinations (1) · Drug Delivery Systems (1) · Endoscopic Mucosal Resection (1) · Esophagectomy (1) · Folfox protocol (1) · Gastrectomy (1) · IFL protocol (1) · Interferon alpha-2 (1)
Aarhus University Hospital (2) · Centre Hospitalier Universitaire, Amiens (2) · Copenhagen University Hospital, Rigshospitalet (2) · Peking University Cancer Hospital & Institute (2) · Region Örebro County (2) · Samsung Medical Center (2) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (2) · University College, London (2) · Yunnan Cancer Hospital (2) · AbbVie (1) · Abdelwahab Hashem (1) · Abramson Cancer Center at Penn Medicine (1) · AiViva BioPharma, Inc. (1) · Asan Medical Center (1) · Associació per a la Recerca Oncologica, Spain (1)
United States (20) · China (15) · United Kingdom (8) · France (7) · South Korea (6) · Spain (5) · Denmark (4) · Germany (4) · Sweden (4) · Belgium (3) · Canada (3) · Czechia (3) · Egypt (3) · Italy (3) · Netherlands (3)
Alexander Lin, MD (1) · Amparo Garcia Tejedor, MDPhD (1) · Andrew Green (1) · Anurag K Singh (1) · Ashutosh K. Tewari, MD (1) · Ayal A Aizer, MD, MHS (1) · Baju Adji (1) · Brad Schoengood (1) · Brasil S Neto, PhD (1) · Byung Joo Chae (1) · Calum MacAulay, Ph.D (1) · Catherine Poh, DDS, PhD (1) · Colin Simonson, MD (1) · Daniel R Leff, MBBS FRCS (Gen Surg) MS PhD (1)
PMID 14575828, PMID 16982773, PMID 17960012, PMID 18784101, PMID 19672942, PMID 21233014, PMID 21437225, PMID 21714641, PMID 22026481, PMID 22072149, PMID 22298678, PMID 22327172, PMID 22791786, PMID 23110817, PMID 23914987, PMID 24780112, PMID 25049329, PMID 25528723, PMID 25851632, PMID 26178760, PMID 26991020, PMID 27588192, PMID 28189914, PMID 28490940, PMID 28533474, PMID 29658848, PMID 29658856, PMID 30171396, PMID 30225621, PMID 30280658, PMID 30742122, PMID 30875013, PMID 30877499, PMID 31162856, PMID 31168572, PMID 31280965, PMID 31679945, PMID 31731014, PMID 31785337, PMID 32154773, PMID 32221752, PMID 32380537, PMID 32654362, PMID 33034628, PMID 33219848, PMID 33398548, PMID 33487427, PMID 33515668, PMID 33538338, PMID 34979601
2008 (1), 2014 (1), 2019 (1), 2025 (1), R01DK046887 (1)