53 completed, 15 unknown, 8 terminated, 4 recruiting. 35 Phase 1, 22 Phase 4, 12 Phase 3, 9 Phase 2, 7 Not applicable.
Follow Diltiazem: new trials by email Literature Review of Diltiazem trials Research Report on Diltiazem
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of MK-4082 in Healthy Participants (MK-4082-005) MK-4082, Diltiazem, Rescue medication - Healthy | Phase 1 | Recruiting | Merck Sharp & Dohme LLC | 28 | 2026-07-20 | 2026-08-05 |
| Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy Biospecimen Collection, Capecitabine, Diltiazem Hydrochloride - Malignant Digestive System Neoplasm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-04-30 | 2026-06-02 |
| The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction mavacamten, Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol, diltiazem - Hypertrophic Cardiomyopathy (HCM) | Phase 4 | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 132 | 2026-03-01 | 2026-09-15 |
| A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022) Nemtabrutinib, Diltiazem - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 26 | 2025-12-08 | 2026-06-29 |
| Adenosine vs Diltiazem for Treatment of SVT in the ED adenosine, diltiazem - Supraventricular Tachycardia (SVT) | Phase 4 | Recruiting | Anne E. Zepeski | 20 | 2025-08-01 | 2026-05-28 |
| PERceptions of Diltiazem Versus ADEnosine for Treatment of Supraventricular Tachycardia in the Emergency Department IV adenosine, IV diltiazem - Supraventricular Tachycardia (SVT) | Recruiting | University of Iowa | 100 | 2025-04-04 | 2026-08-21 | |
| A Study of the Effect of Multiple Doses of Diltiazem on the Plasma Levels of MK-6916 in Healthy Participants (MK-6916-005) MK-6916, Diltiazem - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 37 | 2025-02-27 | 2025-08-26 |
| Diltiazem in Jervell and Lange-Nielsen Syndrome diltiazem - Jervell and Lange Nielsen Syndrome | Phase 4 | Completed | Vanderbilt University Medical Center | 1 | 2024-10-16 | 2025-10-14 |
| A Study of Diltiazem With a Single Dose of MK-6552 in Healthy Adult Participants (MK-6552-007) MK-6552, Diltiazem - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 14 | 2024-06-13 | 2024-10-28 |
| A Clinical Study of MK-4318 and Diltiazem in Healthy People (MK-4318-003) MK-4318, Diltiazem - Healthy, Pain | Phase 1 | Completed | Merck Sharp & Dohme LLC | 19 | 2024-02-09 | 2024-11-18 |
| A Drug-Drug Interaction Study of Diltiazem and MK-1167 in Healthy Adult Participants (MK-1167-006) MK-1167, Diltiazem - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 16 | 2023-10-17 | 2024-11-25 |
| Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor As needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil) - Atrial Fibrillation, Diastolic Dysfunction | Phase 1 | Unknown | University of Vermont | 20 | 2023-02-06 | 2023-03-03 |
| Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease Bisoprolol, Diltiazem, Placebo - Coronary Microvascular Dysfunction, Microvascular Angina | Phase 4 | Unknown | Charite University, Berlin, Germany | 132 | 2022-03-04 | 2022-03-24 |
| A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Single-dose of Danicamtiv in Healthy Participants Danicamtiv, Itraconazole, Diltiazem - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 30 | 2021-12-15 | 2022-08-10 |
| Assessment of Intravenous Rate Control Response in Atrial Fibrillation Trial (AIRCRAFT) Beta-blocker strategy, Calcium channel blocker strategy, Physician preference strategy - Atrial Fibrillation | Phase 4 | Withdrawn | Boston University | 2021-12-01 | 2021-12-15 | |
| Rhythm Control Versus Rate Control for New Onset Atrial Fibrillation Amiodarone, diltiazem or esmolol - Atrial Fibrillation New Onset, Atrial Fibrillation Paroxysmal | Not applicable | Terminated | Seoul National University Hospital | 1 | 2021-07-01 | 2023-07-18 |
| Efficacy of Oral Verapamil and Oral Diltiazim on Reduction of Intraoperative Bleeding During Endoscopic Sinus Surgery Under General Anesthesia Verapamil, Diltiazem, Placebo - Verapamil, Diltiazim | Early Phase 1 | Unknown | Assiut University | 135 | 2021-03-01 | 2021-03-10 |
| Heart Rate Controller in Computed Tomography Coronary Angiography Metoprolol tartrate, Ivabradine, Diltiazem - Heart Rate, Coronary Computed Tomography Angiography | Phase 4 | Unknown | Mahidol University | 246 | 2021-01-30 | 2022-05-17 |
| Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Participants With B-Cell Malignancies Zanubrutinib, Fluconazole, Diltiazem - B-cell Malignancies | Phase 1 | Completed | BeiGene | 26 | 2020-11-15 | 2024-10-26 |
| Rate Control in Patients With Atrial Fibrillation Atenolol, Bisoprolol, Metoprolol, Nebivolol, Propranolol, Diltiazem, Verapamil, digoxin - Atrial Fibrillation, Rate Control | Not applicable | Completed | National Taiwan University Hospital | 13 | 2020-10-21 | 2026-01-16 |
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Atrial Fibrillation (13) · Hypertension (9) · Cardiovascular Diseases (5) · Arrhythmias, Cardiac (3) · Coronary Vasospasm (3) · Fissure in Ano (3) · Heart Diseases (3) · Pain (3) · Atherosclerosis (2) · Atrial Flutter (2) · Cardiomyopathy, Hypertrophic (2) · Coronary Disease (2) · Diabetes Mellitus (2) · Heart Failure (2) · Microvascular Angina (2)
Merck Sharp & Dohme LLC (6) · Ventrus Biosciences, Inc (5) · AstraZeneca (3) · Bristol-Myers Squibb (3) · Mayo Clinic (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Asker & Baerum Hospital (2) · Assiut University (2) · Food and Drug Administration (FDA) (2) · Mahidol University (2) · Seoul National University Hospital (2) · Tehran University of Medical Sciences (2) · University of Arkansas (2) · Abderrahmane Mami Hospital (1) · American University of Beirut Medical Center (1)
United States (43) · China (6) · Germany (4) · Canada (3) · France (3) · South Korea (3) · Iran (2) · Netherlands (2) · Norway (2) · United Kingdom (2) · Australia (1) · Belgium (1) · Bulgaria (1) · Denmark (1) · Iraq (1)
Carlos Sanabria, MD (2) · Adam P Bress, PharmD, MS (1) · Alison Oliveto, Ph.D. (1) · Alison Oliveto, PhD (1) · Allan Walkey, MD (1) · Andreas Nordholm-Carstensen, MD (1) · Andrew G Hill, MBChB, MD, EdD, FRACS, FACS (1) · Andrew Selwyn (1) · Anne Zepeski, PharmD (1) · Annelize Koch, MBChB, FFPM (1) · Annick Steib, MD, PhD (1) · Anthony R Godfrey, PharmD (1) · Ayman Al-Jazaeri (1)
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R01DA010017 (2), 2005 (1), 2014 (1), 2015 (1), 2016 (1), 2018 (1), K23HL078901 (1), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1), N01HC95183 (1), N01HC95184 (1), R01GM067308 (1)