16 completed. 16 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 16 |
| Phase 2 | 5 | Completed 5 |
Follow Obstructive Sleep Apnea: new trials by email Literature Review of Obstructive Sleep Apnea trials Research Report on Obstructive Sleep Apnea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bioavailability, Bioequivalence and Tolerability of IHL-42X Compared to the Reference Drugs IHL42X, Acetazolamide 250 MG, Dronabinol 2.5 MG - Obstructive Sleep Apnea | Phase 1 | Completed | Incannex Healthcare Ltd | 125 | 2023-09-08 | 2025-01-17 |
| Acetazolamide on REM OSA Placebo oral capsule, Acetazolamide - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Completed | Brigham and Women's Hospital | 11 | 2023-01-30 | 2026-01-20 |
| Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED) Dosing 1: Atomoxetine, AD313 - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Completed | Apnimed | 15 | 2021-10-19 | 2023-04-07 |
| Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease? Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air - OSA, Sleep Apnea | Phase 1 | Completed | University of California, San Diego | 182 | 2021-10-08 | 2026-05-11 |
| Evaluate Sunosi® PK in Breast Milk and Plasma of Healthy Postpartum Women Following Single Dose Oral Administration Solriamfetol 150 mg Oral Tablet - Narcolepsy, Obstructive Sleep Apnea | Phase 1 | Completed | Axsome Therapeutics, Inc. | 6 | 2021-08-27 | 2023-04-14 |
| A Study to Learn More About How Safe BAY2586116 is, How it Affects the Body, How it Moves Into, Through and Out of the Body at Different Doses in Healthy Japanese Male Participants After Taking Single and Multiple Doses Through the Nose BAY2586116, Placebo - Obstructive Sleep Apnea | Phase 1 | Completed | Bayer | 36 | 2021-05-11 | 2023-03-01 |
| Study of TAK-925 in Participants With Obstructive Sleep Apnea (OSA) Who Are Experiencing Excessive Daytime Sleepiness (EDS) Despite Adequate Use of Continuous Positive Airway Pressure (CPAP) TAK-925, Placebo - Obstructive Sleep Apnea | Phase 1 | Completed | Millennium Pharmaceuticals, Inc. | 25 | 2019-11-21 | 2020-04-20 |
| A Study to Investigate the Effects of ACT-541468 on Nighttime Respiratory Function in Patients With Mild to Moderate Obstructive Sleep Apnea ACT-541468, Placebo - Obstructive Sleep Apnea | Phase 1 | Completed | Idorsia Pharmaceuticals Ltd. | 28 | 2019-03-14 | 2019-12-19 |
| Pharmacological Activation of HMN for OSA Placebo oral capsule, LTM1201L, LTM1201LN - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Completed | Brigham and Women's Hospital | 6 | 2018-10-30 | 2020-02-24 |
| Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea Placebo, Lemborexant 10 mg, Lemborexant 25 mg - Obstructive Sleep Apnea, Healthy Subjects | Phase 1 | Completed | Eisai Inc. | 146 | 2018-02-21 | 2020-02-17 |
| Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans Intermittent hypoxia, Indomethacin, Celecoxib - Obstructive Sleep Apnea, Hypertension | Phase 1 / Phase 2 | Completed | University of Calgary | 12 | 2011-01-01 | 2011-12-05 |
| Neuromodulation Therapy Device for the Treatment of Sleep Apnea Neuromodulation Therapy Device (NMTD) - Obstructive Sleep Apnea | Phase 1 | Completed | Mayo Clinic | 18 | 2010-02-01 | 2013-05-29 |
| Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea moderate-intensity aerobic and resistance training, low-intensity stretching - Obstructive Sleep Apnea | Phase 1 / Phase 2 | Completed | University of South Carolina | 43 | 2009-08-01 | 2011-11-24 |
| Trial of Auto Continuous Positive Airway Pressure (CPAP) CPAP, autoCPAP - Obstructive Sleep Apnea | Phase 1 | Completed | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 1 | 2009-08-01 | 2010-02-16 |
| CPAP Therapy in Patients With Heart Failure and Obstructive Sleep Apnea. Positron Emission Tomography - Heart Failure, Obstructive Sleep Apnea | Phase 1 | Completed | Ottawa Heart Institute Research Corporation | 67 | 2005-07-01 | 2018-05-30 |
| New Pharmacological Treatment for Obstructive Sleep Apnea mirtazapine - Obstructive Sleep Apnea | Phase 1 | Completed | US Department of Veterans Affairs | 2003-10-01 | 2009-01-21 |
Sleep Apnea, Obstructive (16) · Sleep Apnea Syndromes (5) · Alzheimer Disease (1) · Cardiovascular Diseases (1) · Disorders of Excessive Somnolence (1) · Heart Failure (1) · Hypertension (1) · Hypoxia (1) · Myocardial Infarction (1) · Narcolepsy (1) · Respiratory Aspiration (1) · Sleep Wake Disorders (1) · Stroke (1)
Apnea (16) · Dyssomnias (16) · Nervous System Diseases (16) · Respiration Disorders (16) · Respiratory Tract Diseases (16) · Sleep Disorders, Intrinsic (16) · Sleep Wake Disorders (15) · Sleep Apnea Syndromes (11) · Brain Diseases (2) · Central Nervous System Diseases (2) · Heart Diseases (2) · Mental Disorders (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Cardiovascular Diseases (1)
Acetazolamide (2) · Atomoxetine Hydrochloride (1) · Celecoxib (1) · Dronabinol (1) · Indomethacin (1) · Magnetic Resonance Spectroscopy (1) · Mirtazapine (1) · Oxygen (1) · Resistance Training (1) · TAK-925 (1) · Tablets (1) · daridorexant (1) · lemborexant (1) · solriamfetol (1)
Brigham and Women's Hospital (2) · Apnimed (1) · Axsome Therapeutics, Inc. (1) · Bayer (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Eisai Inc. (1) · Idorsia Pharmaceuticals Ltd. (1) · Incannex Healthcare Ltd (1) · Mayo Clinic (1) · Millennium Pharmaceuticals, Inc. (1) · Ottawa Heart Institute Research Corporation (1) · US Department of Veterans Affairs (1) · University of Calgary (1) · University of California, San Diego (1) · University of South Carolina (1)
United States (10) · Canada (2) · Australia (1) · Belgium (1) · Germany (1) · Japan (1)
Christopher E Kline, MS (1) · Daniel Rodenstein, MD (1) · Emir Redzepagic, MBBS (1) · John G. Park, M.D. (1) · Marc J Poulin, PhD (1) · Phillip Ryan, MBBS (1) · Rob S Beanlands, MD, FRCP C (1) · Ron Farkas, MD, PhD (1) · Shawn D Youngstedt, PhD (1)
PMID 21632834, PMID 22131599, PMID 22572632, PMID 22893765, PMID 24815497, PMID 33305817, PMID 35306405, PMID 36805833, PMID 40135690, PMID 40848323, PMID 41025403, PMID 41781273, PMID 42730864
2018 (1)