37 completed, 6 unknown, 5 recruiting, 3 terminated. 27 Not applicable, 8 Phase 4, 5 Phase 2, 4 Early Phase 1, 3 Phase 1.
Follow Nicotine Addiction: new trials by email Literature Review of Nicotine Addiction trials Research Report on Nicotine Addiction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Appointment Reminder Strategies on Smoking Cessation Clinic Attendance Standard phone call, phone call with MINDSPACE elements - Behavioral Intervention, Nicotine Addiction | Not applicable | Not yet recruiting | Medical University of Gdansk | 300 | 2026-08-01 | 2026-08-21 |
| Non-Invasive Deep Brain Neuromodulation for Smoking Cessation Low intensity focused ultrasound with active stimulations, low intensity focused ultrasound with sham stimulations - Nicotine Addiction | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 100 | 2026-04-13 | 2026-06-23 |
| Semaglutide for Smoking Cessation in Patients With Diabetes Semaglutide, Nicotine replacement - Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 100 | 2026-02-13 | 2026-09-08 |
| Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH - Nicotine Addiction | Not applicable | Recruiting | Emory University | 84 | 2026-02-13 | 2026-02-27 |
| CONNECT Cancer Survivors With Tobacco Treatment ELEVATE, ELEVATE-S - Tobacco Use, Tobacco Use Cessation | Not applicable | Active not recruiting | Washington University School of Medicine | 3543 | 2025-07-01 | 2026-07-10 |
| Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community - Substance Use Disorder (SUD), Alcohol Use Disorder (AUD) | Not applicable | Completed | Sigmund Freud PrivatUniversitat | 97 | 2025-05-05 | 2026-09-29 |
| Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder Varenicline Tartrate, Placebo - Nicotine Addiction, Craving | Early Phase 1 | Recruiting | University of California, San Diego | 200 | 2024-11-19 | 2026-03-16 |
| Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids Nicotine Addiction | Enrolling by invitation | Rochester Institute of Technology | 120 | 2024-11-05 | 2026-01-15 | |
| Evaluation of a Smoking Cessation Program for Long-Term Abstinence Quit Center cessation program - Nicotine Addiction, Smoking Cessation | Completed | Quit Center LLC | 371 | 2024-10-28 | 2026-09-17 | |
| Sex Differences in E-cig Perception: Study 1 E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3 - Nicotine Addiction, E-Cig Use | Not applicable | Completed | Yale University | 66 | 2024-04-30 | 2026-10-02 |
| Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects Bupropion, Nicotine replacement therapy (Nicotine patches) - Tobacco Smoking, Tobacco Withdrawal | Phase 4 | Unknown | National Institute of Respiratory Diseases, Mexico | 134 | 2024-01-15 | 2024-02-23 |
| A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults Smartphone app, Text Message, Survey Administration - Nicotine Dependence, Nicotine Addiction | Not applicable | Completed | Fred Hutchinson Cancer Center | 61 | 2024-01-04 | 2025-06-24 |
| Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies Flexiquit Smoking Cessation Intervention - Smoking Cessation, Smoking Cessation Intervention | Unknown | University of Cyprus | 200 | 2023-11-01 | 2024-06-25 | |
| Effects of Exercises on Functional Capacity Exercise - Nicotine Addiction, Respiratory Disease | Not applicable | Unknown | Kırklareli University | 60 | 2023-10-01 | 2024-03-08 |
| Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction n-acetylcysteine, Motivational Enhancement Therapy - Nicotine Dependence, Nicotine Addiction | Phase 4 | Completed | Universitas Indonesia | 90 | 2023-01-01 | 2024-10-08 |
| Effects of Semaglutide on Nicotine Intake Semaglutide, Sham/placebo - Tobacco Use Disorder, Nicotine Addiction | Phase 2 | Completed | University of North Carolina, Chapel Hill | 24 | 2022-10-07 | 2025-08-22 |
| Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers Nicotine, Cigarette - Nicotine Withdrawal, Nicotine Addiction | Phase 1 | Completed | Johns Hopkins University | 71 | 2022-07-27 | 2026-07-23 |
| Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency e-liquid 1, e-liquid 2, e-liquid 3 - Nicotine Vaping, Nicotine Dependence | Not applicable | Completed | American University of Beirut Medical Center | 142 | 2022-07-13 | 2026-09-18 |
| Mobile Health for Problematic Behaviors and Substance Use mobile application - Addiction, Behavioral Addiction | Not applicable | Unknown | PredictWatch | 600 | 2022-06-21 | 2022-07-01 |
| Circuitry-Guided Smoking Cessation in Schizophrenia (UH3) active F8-coil delivered rTMS, active H-coil delivered rTMS - Smoking Cessation, Nicotine Addiction | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 50 | 2022-06-01 | 2026-09-16 |
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Tobacco Use Disorder (57) · Smoking (19) · Smoking Cessation (18) · Vaping (9) · Cigarette Smoking (6) · Behavior, Addictive (5) · Tobacco Smoking (5) · Substance-Related Disorders (4) · Schizophrenia (3) · Recurrence (2) · Alcoholism (1) · Diabetes Mellitus, Type 2 (1) · Head and Neck Neoplasms (1) · Marijuana Abuse (1) · Neoplasms (1)
Chemically-Induced Disorders (57) · Mental Disorders (57) · Substance-Related Disorders (53) · Behavior (40) · Health Behavior (18) · Smoking (14) · Tobacco Use (8) · Compulsive Behavior (5) · Impulsive Behavior (5) · Tobacco Smoking (4) · Schizophrenia Spectrum and Other Psychotic Disorders (3) · Disease Attributes (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Alcohol-Related Disorders (1)
Nicotine (7) · Tobacco Use Cessation Devices (7) · Nicotine Replacement Therapy (5) · Varenicline (3) · Bupropion (2) · Cycloserine (2) · Electronic Nicotine Delivery Systems (2) · Sugars (2) · semaglutide (2) · Acetylcysteine (1) · Chemoradiotherapy (1) · Chewing Gum (1) · Cognitive Behavioral Therapy (1) · Cognitive Training (1) · Counseling (1)
University of Pennsylvania (8) · Yale University (4) · Centre for Addiction and Mental Health (2) · Click Therapeutics, Inc. (2) · Duke University (2) · Rochester Institute of Technology (2) · The University of Texas Health Science Center, Houston (2) · University of California, San Francisco (2) · University of Cyprus (2) · American University of Beirut Medical Center (1) · Baylor College of Medicine (1) · Centre Oscar Lambret (1) · Creighton University (1) · Emory University (1) · Fred Hutchinson Cancer Center (1)
United States (42) · Canada (4) · Cyprus (2) · Poland (2) · Turkey (Türkiye) (2) · Austria (1) · France (1) · Indonesia (1) · Lebanon (1) · Mexico (1) · Mongolia (1)
Caryn Lerman, PhD (4) · Xiaoming Du, PhD (2) · Amy J Arouni, MD (1) · Brian M Iacoviello, PhD (1) · Caryn Lerman, Ph.D. (1) · Christian Hendershot, PhD (1) · Dae Han, PhD (1) · Danielle Davis (1) · Davaalkham Dambadarjaa, MD (1) · Edward C Hensel, PhD in Mechanical Engineering (1) · Hedy Kober, Ph.D. (1) · Jaimee Heffner (1)
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