19 enrolling by invitation. 19 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 19 | Enrolling by invitation 19 |
Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Osilodrostat and Cabergoline in Cushing's Disease osilodrostat, osilodrostat and cabergoline - Cushing Disease Due to Increased ACTH Secretion | Phase 4 | Enrolling by invitation | University of Basrah | 50 | 2026-05-11 | 2026-05-22 |
| ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty Zynrelef, Bupivacaine - Total Shoulder Arthroplasty, Pain Management | Phase 4 | Enrolling by invitation | Washington University School of Medicine | 86 | 2026-02-14 | 2026-02-19 |
| Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App) beta blockers, StudyU Application - HFrEF - Heart Failure With Reduced Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Weill Medical College of Cornell University | 5 | 2026-02-10 | 2026-02-19 |
| Effects of Ocrelizumab Treatment on Immune Cells in Lymph Nodes in Multiple Sclerosis Ocrelizumab - Multiple Sclerosis, Relapsing-Remitting | Phase 4 | Enrolling by invitation | University of California, San Francisco | 5 | 2025-02-04 | 2026-03-27 |
| Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases Shingrix, vaccination with 2 doses of Shingrix vaccine - Systemic Vasculitis, Spondylarthropathies | Phase 4 | Enrolling by invitation | Region Skane | 240 | 2024-12-17 | 2025-01-10 |
| Evaluating Worksite Sleep Health Coaching in Firefighters: The Sleep Assistance for Firefighters Study firefighter Sleep Health Coaching Intervention (ffSHC), Control (Minimally Enhanced Usual Care) - Cognitive Behavioral Therapy, Sleep Initiation and Maintenance Disorders | Phase 4 | Enrolling by invitation | University of Arizona | 400 | 2024-10-21 | 2026-07-16 |
| Cabergoline in the Management of Nonfunctioning Pituitary Adenoma Cabergoline 0.5 MG - Pituitary Adenoma, MRI | Phase 4 | Enrolling by invitation | National Taiwan University Hospital | 30 | 2024-05-20 | 2025-06-24 |
| 3T Therapy in the Treatment of MDA5-positive Dermatomyositis Tofacitinib 5 MG - Dermatomyositis | Phase 4 | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 133 | 2024-03-19 | 2024-06-03 |
| Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome Low dose naltrexone, Placebo sugar capsules - Complex Regional Pain Syndrome, Chronic Pain | Phase 4 | Enrolling by invitation | Hospital for Special Surgery, New York | 40 | 2024-01-02 | 2026-11-06 |
| Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study) semaglutide, Metformin - Diabetes Mellitus, Cardiovascular Diseases | Phase 4 | Enrolling by invitation | China-Japan Friendship Hospital | 142 | 2024-01-01 | 2025-05-07 |
| Focal Cerebral Arteriopathy Steroid Trial methylprednisolone, prednisolone, prednisone - Pediatric Stroke, Arteriopathy | Phase 4 | Enrolling by invitation | University of California, San Francisco | 80 | 2023-10-01 | 2026-01-26 |
| MIBG in Aging and Neurologic Disorders meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy - Lewy Body Disease, Dementia | Phase 4 | Enrolling by invitation | Mayo Clinic | 50 | 2023-05-08 | 2026-07-30 |
| A Study of Paravertebral Block in Thoracic Outlet Syndrome Ropivacaine - Thoracic Outlet Syndrome | Phase 4 | Enrolling by invitation | Mayo Clinic | 50 | 2022-10-05 | 2025-11-14 |
| Oxycodone and Sufentanil for Analgesia in Hip Surgery Oxycodone Hydrochloride, Sufentanil Citrate - Analgesia, Patient-Controlled | Phase 4 | Enrolling by invitation | West China Hospital | 570 | 2018-12-01 | 2024-10-08 |
| Longitudinal Imaging Biomarkers of Disease Progression in DLB 18F-Flortaucipir - Lewy Body Disease | Phase 4 | Enrolling by invitation | Kejal Kantarci | 135 | 2018-06-25 | 2026-03-19 |
| Quality Improvement and Practice Based Research in Neurology Using the EMR Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description) - Brain Tumors, Epilepsy | Phase 4 | Enrolling by invitation | Endeavor Health | 3300 | 2016-05-01 | 2025-08-24 |
| BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric Patients Blood sample collection - Botulism | Phase 4 | Enrolling by invitation | Emergent BioSolutions | 10 | 2014-10-01 | 2026-01-16 |
| DaTSCAN Imaging in Aging and Neurodegenerative Disease I-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan - Dementia, Parkinsonism | Phase 4 | Enrolling by invitation | Mayo Clinic | 500 | 2011-10-01 | 2026-03-10 |
| Imaging of Brain Amyloid Plaques in the Aging Population Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451) - Alzheimer's Disease, Dementia With Lewy Bodies | Phase 4 | Enrolling by invitation | Mayo Clinic | 8000 | 2008-04-01 | 2026-06-23 |
Agnosia (3) · Cognitive Dysfunction (3) · Dementia (3) · Lewy Body Disease (3) · Alzheimer Disease (2) · Parkinsonian Disorders (2) · REM Sleep Behavior Disorder (2) · Adrenal Insufficiency (1) · Arthritis (1) · Arthritis, Juvenile (1) · Arthritis, Psoriatic (1) · Botulism (1) · Brain Concussion (1) · Brain Neoplasms (1) · Cardiovascular Diseases (1)
Brain Diseases (11) · Central Nervous System Diseases (11) · Cardiovascular Diseases (7) · Mental Disorders (7) · Vascular Diseases (7) · Neurocognitive Disorders (6) · Basal Ganglia Diseases (5) · Movement Disorders (5) · Neurodegenerative Diseases (5) · Cerebrovascular Disorders (4) · Neurologic Manifestations (4) · Neuromuscular Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4)
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · Cabergoline (2) · 3-Iodobenzylguanidine (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Adrenergic beta-Antagonists (1) · Bupivacaine (1) · Iodine-123 (1) · Metformin (1) · Methylprednisolone (1) · Naltrexone (1) · Osilodrostat (1) · Oxycodone (1) · Prednisolone (1) · Prednisone (1) · Radionuclide Imaging (1)
Mayo Clinic (4) · University of California, San Francisco (2) · China-Japan Friendship Hospital (1) · Emergent BioSolutions (1) · Endeavor Health (1) · Hospital for Special Surgery, New York (1) · Kejal Kantarci (1) · National Taiwan University Hospital (1) · Region Skane (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · University of Arizona (1) · University of Basrah (1) · Washington University School of Medicine (1) · Weill Medical College of Cornell University (1) · West China Hospital (1)
United States (12) · China (3) · Iraq (1) · Sweden (1) · Taiwan (1)
Bradley Boeve, MD (2) · Abbas A Mansour (1) · Alexander Aleem, MD (1) · Alexandra Sideris, PhD (1) · Haider A Alidrisi (1) · Heather J Fullerton, MD, MAS (1) · Houssam Farres, MD (1) · Ibrahim H Hussein, MD (1) · Joseph Sabatino, MD, PhD (1) · Kejal Kantarci, MD (1) · Parag Goyal, MD, MSc (1) · Ren Liao, M.D (1) · Semih Gungor, M.D. (1) · Val Lowe, M.D. (1)
PMID 29560382, PMID 32198310, PMID 33348363, PMID 33408148, PMID 33422890, PMID 36844148, PMID 40095065, PMID 40351190
2023 (1), 4UH3NS119702-02 (1), R01AG011378 (1), R01HL162799 (1), U01AG006786 (1), U01NS100620 (1)