648 terminated. 648 Phase 3, 115 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 648 | Terminated 648 |
| Phase 2 | 115 | Terminated 115 |
Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ARD-101 for Treatment of PWS: The Hunger Elimination or Reduction Objective Trial Placebo, ARD-101 - Hyperphagia, Prader-Willi Syndrome | Phase 3 | Terminated | Aardvark Therapeutics, Inc. | 68 | 2024-12-20 | 2026-06-30 |
| Open-Label Extension of EryDex Study IEDAT-04-2022 Dexamethasone sodium phosphate - Ataxia Telangiectasia | Phase 3 | Terminated | Quince Therapeutics S.p.A. | 101 | 2024-12-11 | 2026-05-05 |
| An Open-Label Study to Assess the Long-term Safety of AXS-05 in Subjects With Dementia of the Alzheimer's Type, ADVANCE-2 and ACCORD-2 Extension Study AXS-05 (dextromethorphan-bupropion) - Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease | Phase 3 | Terminated | Axsome Therapeutics, Inc. | 139 | 2024-11-21 | 2026-06-25 |
| RolloverTreatment With Triumeq for People With ALS Following the Lighthouse II Trial Abacavir 600mg, Lamivudine 300mg and Dolutegravir 50mg (Triumeq) - Amyotrophic Lateral Sclerosis, ALS | Phase 3 | Terminated | Macquarie University, Australia | 12 | 2024-11-15 | 2025-06-08 |
| A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure Aticaprant, Placebo - Depressive Disorder, Major, Anhedonia | Phase 3 | Terminated | Janssen Research & Development, LLC | 47 | 2024-09-19 | 2026-06-08 |
| The Hunger Elimination or Reduction Objective (HERO ) Open -Label Extension (OLE) Trial ARD-101 - Hyperphagia, Prader-Willi Syndrome | Phase 3 | Terminated | Aardvark Therapeutics, Inc. | 19 | 2024-07-23 | 2026-06-30 |
| A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With Aticaprant Aticaprant, Placebo - Depressive Disorder, Major, Anhedonia | Phase 3 | Terminated | Janssen Research & Development, LLC | 101 | 2024-06-26 | 2026-02-17 |
| A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures BHV-7000, Placebo - Generalized Epilepsy | Phase 2 / Phase 3 | Terminated | Biohaven Therapeutics Ltd. | 27 | 2024-06-20 | 2026-03-24 |
| A Study Evaluating Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to Fenfluramine Soticlestat - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 3 | Terminated | Takeda | 1 | 2024-04-25 | 2026-09-04 |
| Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD Subjects Experimental: ALZ-801 - Early Alzheimer's Disease | Phase 3 | Terminated | Alzheon Inc. | 163 | 2024-04-02 | 2026-06-25 |
| Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy Bupivacaine injection, Placebo, Monitored Anesthesia Care - Pleural Disease, Postoperative Pain | Phase 3 | Terminated | Icahn School of Medicine at Mount Sinai | 33 | 2024-03-28 | 2025-05-01 |
| Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial Fentanyl Citrate, Esketamine - Acute Pain Due to Trauma, Analgesia | Phase 3 | Terminated | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 235 | 2024-01-11 | 2026-09-15 |
| Continuation Study for Latozinemab Latozinemab - Neurodegenerative Diseases | Phase 3 | Terminated | Alector Inc. | 17 | 2023-12-08 | 2026-01-21 |
| Maimonides Minocycline in Stroke Study Minocycline - Stroke, Acute, Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Maimonides Medical Center | 2 | 2023-11-01 | 2025-12-17 |
| Efficacy and Safety of SYNB1934 in Patients With PKU (SYNPHENY-3) SYNB1934v1, Placebo - Phenylketonuria | Phase 3 | Terminated | Synlogic | 35 | 2023-07-05 | 2024-06-20 |
| LIFE-DSR-Biomarker Sub-study of Biomarkers in Down Syndrome Related Alzheimer's Disease (DS-AD) [18F]MK-6240 - Down Syndrome | Phase 3 | Terminated | LuMind IDSC Foundation | 5 | 2023-06-27 | 2025-03-06 |
| Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy Oxycodone, Acetaminophen, Ketamine - Pain Management, Opioid Use | Phase 2 / Phase 3 | Terminated | Wake Forest University Health Sciences | 58 | 2023-04-18 | 2026-06-15 |
| AGItated Patients Management: intraNASAL Midazolam vs Intramuscular Loxapine Intranasal midazolam, Intramuscular loxapine - Emergence Delirium | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 1 | 2023-04-09 | 2024-05-28 |
| A Study of Safety of Weekly Subcutaneous Pegzilarginase in Subjects With Arginase 1 Deficiency Pegzilarginase - Arginase I Deficiency, Hyperargininemia | Phase 3 | Terminated | Aeglea Biotherapeutics | 3 | 2023-04-04 | 2023-07-27 |
| Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT) Tenecteplase - Stroke, Ischemic | Phase 3 | Terminated | General Hospital of Shenyang Military Region | 145 | 2023-03-21 | 2025-07-02 |
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Alzheimer Disease (65) · Stroke (51) · Epilepsy (36) · Parkinson Disease (31) · Ischemic Stroke (29) · Multiple Sclerosis (28) · Dementia (26) · Agnosia (24) · Seizures (22) · Pain (21) · Brain Injuries, Traumatic (18) · Amyotrophic Lateral Sclerosis (16) · Muscular Dystrophy, Duchenne (15) · Multiple Sclerosis, Relapsing-Remitting (14)
Central Nervous System Diseases (384) · Brain Diseases (347) · Pathological Conditions, Signs and Symptoms (249) · Neurologic Manifestations (185) · Signs and Symptoms (183) · Neurodegenerative Diseases (151) · Vascular Diseases (119) · Mental Disorders (118) · Cardiovascular Diseases (117) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (105) · Cerebrovascular Disorders (94) · Genetic Diseases, Inborn (92) · Neuromuscular Diseases (92) · Neurocognitive Disorders (89)
Aspirin (10) · Sodium Chloride (9) · Saline Solution (8) · Levetiracetam (7) · Prednisone (7) · Radiotherapy (7) · Cannabidiol (6) · Dexmedetomidine (6) · Haloperidol (6) · Methylprednisolone (6) · Radiosurgery (6) · Sugars (6) · Tissue Plasminogen Activator (6) · aflibercept (6) · gantenerumab (6)
Pfizer (19) · Biogen (17) · Novartis Pharmaceuticals (12) · GlaxoSmithKline (10) · Hoffmann-La Roche (10) · Assistance Publique - Hôpitaux de Paris (8) · Sanofi (8) · Teva Branded Pharmaceutical Products R&D, Inc. (8) · Eisai Inc. (7) · Eli Lilly and Company (7) · Merck Sharp & Dohme LLC (7) · Alexion Pharmaceuticals, Inc. (6) · H. Lundbeck A/S (6) · Jazz Pharmaceuticals (6) · Columbia University (4)
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Pablo Velazquez-Martin, MD (4)
PMID 40603145, PMID 39556389, PMID 41537338, PMID 42841310, PMID 25018648, PMID 25325609, PMID 26297092, PMID 26464429, PMID 27176461, PMID 27334799, PMID 27767991, PMID 27807285, PMID 28304242, PMID 29486396, PMID 29685591, PMID 29716940, PMID 30045949, PMID 30936738, PMID 31764959, PMID 33049114, PMID 34376508, PMID 34807243, PMID 35277540, PMID 35384522, PMID 35747889, PMID 36121669, PMID 36410152, PMID 36600109, PMID 36641609, PMID 36700520, PMID 37460385, PMID 37966285, PMID 38165296, PMID 39498781, PMID 39887500, PMID 40302041, PMID 42598748, PMID 15756405, PMID 17303527, PMID 17389552, PMID 17438255, PMID 17450125, PMID 17881719, PMID 18032739, PMID 18041437, PMID 18378947, PMID 18413464, PMID 18480196, PMID 18687132, PMID 18759980
2016 (15), 2019 (13), 2018 (12), 2015 (11), 2017 (11), 2009 (10), 2008 (8), 2014 (8), 2023 (8), 2005 (4), U01NS054630 (2), U10EY011751 (2), 1UF1AG046150-01 (1), K23HL078760 (1), P01HL056693 (1)