8 completed, 5 unknown, 4 recruiting, 3 not yet recruiting. 7 Phase 2, 4 Phase 3, 3 Phase 4, 2 Not applicable.
Follow Nephrotoxicity: new trials by email Literature Review of Nephrotoxicity trials Research Report on Nephrotoxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rutin and Ascorbic Acid for Prevention of Vancomycin-Induced Nephrotoxicity in Adult Patients" - a Clinical Trial Protocol Evaluating Whether Combined Rutin/Vitamin C Supplementation Reduces Kidney Toxicity From Vancomycin, Compared to Vitamin C Alone and Control. Rutin + Ascorbic Acid (RUTA C60®), Ascorbic Acid (C-Retard®) - Nephrotoxicity, Acute Kidney Injuries | Not applicable | Enrolling by invitation | Ain Shams University | 120 | 2026-10-01 | 2026-10-14 |
| Differentiating True Nephrotoxicity From Pseudo-nephrotoxicity: A Prospective Comparative Study of Vancomycin Plus Piperacillin-Tazobactam vs. Meropenem Using Serum Creatinine and Cystatin-C Nephrotoxicity, Bacterial Infections | Not yet recruiting | King Faisal Specialist Hospital & Research Center | 304 | 2026-09-15 | 2026-09-14 | |
| Colistin Nephrotoxicity and Role of Alpha Lipoic Acid alpha lipoic acid drug (thioctic acid acid) - Nephrotoxicity | Phase 3 | Not yet recruiting | Helwan University | 88 | 2026-06-30 | 2026-06-25 |
| Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity Vitamin C, Coenzyme Q 10 - Nephrotoxicity | Phase 2 / Phase 3 | Not yet recruiting | Ain Shams University | 75 | 2026-04-20 | 2026-03-17 |
| Alpha-Lipoic Acid in Mitigating Cisplatin-Induced Nephrotoxicity Alpha-Lipoic Acid (ALA) - Cisplatin Nephrotoxicity, Nephrotoxicity | Phase 2 | Recruiting | Minia University | 50 | 2026-03-10 | 2026-05-04 |
| L-Carnitine Protective Effect in Nephrotoxicity L-Carnitine Tartrate, Placebo - Nephrotoxicity | Phase 2 | Recruiting | Tanta University | 46 | 2025-08-10 | 2025-08-12 |
| Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid in Colistin-Induced Nephrotoxicity Addition of sachets of N-acetyl cysteine 1200 mg twice/day to the maintenance dose of colistin, Addition of Alpha-lipoic acid 600mg twice daily to the maintenance dose of colistin - Nephrotoxicity | Phase 2 / Phase 3 | Completed | Ain Shams University | 180 | 2024-11-01 | 2026-02-17 |
| Integrated Learning Support System Based on Immersive Simulated Training for Nursing Students Integrated Learning Support System, Standard Learning Model - Simulation Training, Learning | Not applicable | Unknown | University of Brasilia | 95 | 2024-08-01 | 2024-07-31 |
| KIdney aNd blooD prESsure ouTcomes in Childhood Cancer Survivors (CCS) Childhood Cancer, Chronic Kidney Diseases | Recruiting | The Hospital for Sick Children | 500 | 2024-01-05 | 2024-04-17 | |
| Effect of Huaier Granule on Nephrotoxicity Associated With Targeted Therapy for Advanced Hepatobiliary Malignancies. Huaier Granule, VEGFR-TKIs - Nephrotoxicity | Phase 2 | Completed | Fudan University | 76 | 2023-01-03 | 2026-02-09 |
| Clinical Outcomes in Adult Patients Undergoing Laparoscopic Surgery Under Neuraxial Anesthesia Mortality, Surgical Complication | Unknown | Asst Melegnano e Martesana | 70 | 2022-10-01 | 2024-04-11 | |
| Cisplatin Disposition and Kidney Injury Granisetron, Ondansetron, Palonosetron - Nephrotoxicity | Phase 3 | Active not recruiting | University of Colorado, Denver | 45 | 2019-11-15 | 2026-09-17 |
| Treatment of Radiation and Cisplatin Induced Toxicities with Tempol Tempol, Placebo Solution - Mucositis, Nephrotoxicity | Phase 2 | Recruiting | Matrix Biomed, Inc. | 120 | 2019-05-13 | 2024-11-20 |
| Assessment of Urinary Neutrophil Gelatinase-Associated Lipocalin to Predict AKI in the NICU urine neutrophil gelatinase -associated lipocalin - Acute Kidney Injury, Nephrotoxicity | Completed | University of Alabama at Birmingham | 148 | 2019-01-28 | 2024-01-05 | |
| Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients Vancomycin Continuous infusion, Vancomycin Intermittent infusion - Gram-Positive Bacterial Infections, Nephrotoxicity | Phase 4 | Unknown | University of Sao Paulo | 222 | 2018-04-28 | 2018-04-05 |
| Assessment of Urinary NGAL to Predict AKI in Children Receiving Multiple Nephrotoxic Medications Acute Kidney Injury, Nephrotoxicity | Completed | Children's Hospital Medical Center, Cincinnati | 134 | 2018-04-23 | 2021-10-05 | |
| 0,9% NaCl Effect on Kidney Function and Glycocalyx in Patients Operated on for Primary Hiparthrosis Plasma-lyte, 0,9% saline - Nephrotoxicity | Phase 4 | Unknown | Regional Hospital Holstebro | 40 | 2015-03-01 | 2015-08-19 |
| Switch From Calcineurin Inhibitor to Belatacept in Pancreas Transplant Recipients Belatacept - Nephrotoxicity | Phase 4 | Completed | Indiana University | 6 | 2014-06-01 | 2017-08-28 |
| Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy Pantoprazole, High-dose methotrexate infusion duration - Osteosarcoma, Nephrotoxicity | Phase 2 | Completed | Children's Hospital of Philadelphia | 13 | 2013-04-01 | 2020-03-16 |
| Aminoglycoside Plasma Level Measurement in Neonates With Infection Nephrotoxicity, Ototoxicity | Unknown | Universitas Indonesia | 25 | 2010-11-01 | 2012-07-10 |
Showing 20 of 22. Sign in to see all of them.
Acute Kidney Injury (5) · Neoplasms (3) · Ototoxicity (3) · Bacterial Infections (1) · Gram-Positive Bacterial Infections (1) · Hypertension (1) · Mucositis (1) · Osteosarcoma (1) · Proteinuria (1) · Renal Insufficiency (1) · Renal Insufficiency, Chronic (1) · Sepsis (1)
Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Male Urogenital Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Urogenital Diseases (6) · Urologic Diseases (6) · Kidney Diseases (5) · Pathologic Processes (5) · Renal Insufficiency (4) · Chemically-Induced Disorders (3) · Drug-Related Side Effects and Adverse Reactions (3) · Ear Diseases (3) · Otorhinolaryngologic Diseases (3) · Radiation Injuries (3) · Wounds and Injuries (3)
Ascorbic Acid (2) · Thioctic Acid (2) · Abatacept (1) · Carnitine (1) · Granisetron (1) · Methotrexate (1) · Ondansetron (1) · Palonosetron (1) · Pantoprazole (1) · Plasma-lyte 148 (1) · Rutin (1) · Sodium Chloride (1) · coenzyme Q10 (1) · tempol (1)
Ain Shams University (3) · Asst Melegnano e Martesana (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Fudan University (1) · Helwan University (1) · Indiana University (1) · King Faisal Specialist Hospital & Research Center (1) · Matrix Biomed, Inc. (1) · Minia University (1) · Regional Hospital Holstebro (1) · Tanta University (1) · The Hospital for Sick Children (1) · Universitas Indonesia (1) · University Hospital, Geneva (1)
United States (7) · Egypt (6) · Brazil (2) · Canada (1) · China (1) · Denmark (1) · Indonesia (1) · Italy (1) · Saudi Arabia (1)
Ahmed Mostafa Abd-Elaziz (1) · Amal Kamal Hussein (1) · Asif Sharfuddin, MD (1) · Asmaa Basem Mohammed (1) · Benji Crane (1) · Breno S Santana, MsC (1) · David Askenazi (1) · Dina H El Adly, MSc (1) · Edgar Jaimes, MD (1) · Eman Magdy Elsayed Elyamany, Assistant lecturer (1) · Eman Mohamed Sadek (1) · Erling B Perdersen, MD, DMSc (1) · Estela M de Oliveira, PhD student (1) · Fatma M Eweda, Master (1) · Frank M Balis, MD (1)
PMID 23557866, PMID 23731573, PMID 29445029, PMID 33677616, PMID 33771116, PMID 38151013, PMID 38955285, PMID 39711135, PMID 39726772
R01GM123330 (1)