264 completed, 113 recruiting, 66 unknown, 56 terminated. 271 Phase 2, 210 Phase 1, 46 Not applicable, 25 Phase 3, 10 Early Phase 1.
Follow Osteosarcoma: new trials by email Literature Review of Osteosarcoma trials Research Report on Osteosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| GD2IL18CART Combined With Bevacizumab for Relapsed and Refractory GD2-positive Solid Tumors Chimeric Antigen Receptor (CAR) Therapy Infusion, Bevacizumab (Avastin) - Neuroblastoma (NBL), Ewing Sarcoma | Phase 1 | Not yet recruiting | Universität Münster | 30 | 2027-10-01 | 2026-11-03 |
| Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-07-01 | 2026-11-02 |
| Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2027-06-01 | 2026-10-30 |
| A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat Archive Sample Retrieval, Biospecimen Collection, pH Low Insertion Peptide-exatecan Conjugate CBX-12 - Recurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 79 | 2027-05-07 | 2026-09-22 |
| RAPID: Phase 2 Platform Trial Of Promising Drugs For AYA Patients With R/R Ewing Sarcoma & DSRCT LX-101 - Ewing Sarcoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 120 | 2027-02-01 | 2026-08-24 |
| my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults my.naviGATE Digital Tool - Sarcoma, Osteosarcoma | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 143 | 2026-11-20 | 2026-10-29 |
| The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma High-dose Methotrexate - Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults | Phase 2 | Recruiting | Wake Forest University Health Sciences | 46 | 2026-10-31 | 2026-11-04 |
| Fight Osteosarcoma Through European Research Evolving Study Platform From Diagnosis to Relapse Experimental group : Cabometyx ® 40mg/m2/day (Max: 60mg/day) , Treatment schedule : Daily**, day 1-28 during 4 weeks (ie. 1 cycle) during 12 cycles - Osteosarcoma, Pediatric Osteosarcoma | Phase 3 | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 530 | 2026-10-07 | 2026-10-26 |
| EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT EWSR1 immunotherapy, Pembrolizumab - Ewing Sarcoma, Desmoplastic Small Round Cell Tumor | Phase 1 | Not yet recruiting | Rabi Hanna | 24 | 2026-10-01 | 2026-09-17 |
| Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors. Dinutuximab beta, Sirolimus and Irinotecan - Osteosarcomas, Bone Cancer | Phase 1 / Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 89 | 2026-10-01 | 2026-10-01 |
| Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma Surgical Resection, Stereotactic Body Radiation Therapy (SBRT), Atezolizumab - Osteosarcoma, Pulmonary Recurrence of Osteosarcoma | Phase 1 | Recruiting | Emory University | 12 | 2026-10-01 | 2026-09-30 |
| A Study to Assess Safety and Efficacy of SOT106 in Patients With LRRC15-positive Advanced Unresectable or Metastatic Osteosarcoma or Soft Tissue Sarcoma SOT106 - Osteosarcoma Metastatic, Soft Tissue Sarcoma (STS) | Phase 1 / Phase 2 | Not yet recruiting | SOTIO Biotech a.s. | 70 | 2026-09-30 | 2026-09-03 |
| Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial Psilocybin (high dose), Psilocybin (low dose), PEARL Therapy - Advanced Cancer, Stage IV Solid Tumor Cancer | Phase 2 | Not yet recruiting | University Health Network, Toronto | 46 | 2026-09-14 | 2026-10-15 |
| Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma Cyclophosphamide, Fludarabine, Mesna - Pediatric Osteosarcoma | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 41 | 2026-08-21 | 2026-11-03 |
| Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma Proton Therapy (Adaptive) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not applicable | Recruiting | St. Jude Children's Research Hospital | 100 | 2026-08-20 | 2026-08-21 |
| Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma Domatinostat, Sirolimus - Sarcoma, Osteosarcoma | Phase 1 / Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 74 | 2026-07-15 | 2026-09-03 |
| NKG2D.Zeta-NK Cell Conditioning With C7R.GD2.CAR-T Cells for Patients With Relapsed or Refractory Osteosarcoma or Neuroblastoma i15.NKG2D.zeta NK cells and C7R.GD2.CARTs cells - Relapsed Neuroblastoma, Refractory Neuroblastoma | Phase 1 | Recruiting | Baylor College of Medicine | 27 | 2026-07-15 | 2026-07-21 |
| Treatment Patterns and Survival Outcomes in High-Grade Osteosarcoma: A Multicenter Retrospective Study High-Grade Osteosarcoma | Recruiting | MedPacto, Inc. | 400 | 2026-07-13 | 2026-10-16 | |
| Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients Lab based 3D Gait Assessment, Wearable Inertial Sensors (In Lab and Remote), Functional Testing & Patient Reported Outcomes - Sarcoma, Bone, Sarcoma, Soft Tissue | Recruiting | St. Jude Children's Research Hospital | 300 | 2026-06-16 | 2026-06-18 | |
| Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma Eflornithine, Topotecan, Cyclophosphamide - Osteosarcoma, Ewing Sarcoma | Phase 2 | Recruiting | Milton S. Hershey Medical Center | 406 | 2026-06-05 | 2026-10-06 |
Showing 20 of 603. Sign in to see all of them.
Sarcoma, Ewing (245) · Sarcoma (237) · Neuroblastoma (141) · Rhabdomyosarcoma (129) · Neuroectodermal Tumors, Primitive, Peripheral (81) · Wilms Tumor (75) · Medulloblastoma (59) · Neoplasms (55) · Bone Neoplasms (53) · Melanoma (46) · Chondrosarcoma (44) · Hepatoblastoma (39) · Recurrence (38) · Rhabdoid Tumor (38)
Neoplasms by Histologic Type (601) · Neoplasms, Bone Tissue (601) · Neoplasms, Connective Tissue (601) · Neoplasms, Connective and Soft Tissue (599) · Neoplasms (548) · Sarcoma (366) · Neoplasms by Site (212) · Neoplasms, Glandular and Epithelial (210) · Neoplasms, Nerve Tissue (210) · Neuroectodermal Tumors (198) · Neoplasms, Germ Cell and Embryonal (194) · Neoplasms, Neuroepithelial (186) · Neuroectodermal Tumors, Primitive (163) · Neoplasms, Muscle Tissue (147) · Myosarcoma (132)
Cyclophosphamide (41) · Doxorubicin (36) · Ifosfamide (36) · Methotrexate (29) · Temozolomide (26) · Etoposide (25) · Irinotecan (25) · Cisplatin (23) · Filgrastim (22) · Vincristine (20) · Gemcitabine (18) · Leucovorin (15) · Magnetic Resonance Spectroscopy (14) · Specimen Handling (14) · Radiotherapy (13)
National Cancer Institute (NCI) (67) · Children's Oncology Group (32) · Peking University People's Hospital (31) · Memorial Sloan Kettering Cancer Center (24) · St. Jude Children's Research Hospital (22) · M.D. Anderson Cancer Center (16) · Istituto Ortopedico Rizzoli (12) · Italian Sarcoma Group (10) · Dana-Farber Cancer Institute (8) · Emory University (8) · Sarcoma Alliance for Research through Collaboration (7) · City of Hope Medical Center (6) · Grupo Espanol de Investigacion en Sarcomas (6) · Gustave Roussy, Cancer Campus, Grand Paris (6) · Second Affiliated Hospital, Zhejiang University, School of Medicine (6)
United States (359) · China (74) · Italy (48) · France (47) · Canada (46) · Spain (31) · Australia (30) · United Kingdom (27) · Puerto Rico (26) · Germany (25) · Netherlands (13) · Poland (10) · South Korea (10) · Switzerland (10) · Sweden (9)
Richard Gorlick, MD (5) · AeRang Kim, MD, PhD (4) · Crystal L Mackall, M.D. (4) · John Nemunaitis, MD (4) · Antonio Casado (3) · Brian H. Kushner, MD (3) · Brigitte C Widemann, M.D. (3) · Claudia Valverde (3) · Elizabeth Fox, MD (3) · Holly Meany, MD (3) · Jonathan Metts, MD (3) · Josefina Cruz (3) · Kim Kramer, MD (3)
PMID 31401903, PMID 22682017, PMID 19451433, PMID 23450030, PMID 25421877, PMID 27567955, PMID 29033609, PMID 30477937, PMID 31013172, PMID 31553693, PMID 32192573, PMID 34416158, PMID 40825172, PMID 11953595, PMID 12509946, PMID 15814645, PMID 15852358, PMID 16234526, PMID 16291387, PMID 16314647, PMID 16421923, PMID 16435380, PMID 16532433, PMID 16551859, PMID 16914576, PMID 17267204, PMID 18048828, PMID 18050289, PMID 18281544, PMID 18391430, PMID 18470481, PMID 18676758, PMID 18809616, PMID 19075272, PMID 19338063, PMID 19430790, PMID 19451429, PMID 20036194, PMID 20044751, PMID 20226028, PMID 20407240, PMID 20460632, PMID 20576718, PMID 20715156, PMID 20943374, PMID 21896345, PMID 22067397, PMID 22088484, PMID 22186789, PMID 22251554
U10CA180886 (22), U10CA098543 (19), 2023 (9), P30CA008748 (6), UM1CA228823 (6), P30CA033572 (5), 2009 (3), 2019 (3), U01CA097452 (3), 2004 (2), 2016 (2), 2017 (2), P30CA016672 (2), P30CA060553 (2), U01CA069856 (2)