20 completed, 12 recruiting, 8 unknown, 3 not yet recruiting. 14 Not applicable, 14 Phase 2, 5 Phase 3, 3 Phase 1, 2 Phase 4.
Follow this condition Literature Review of Ototoxicity trials Research Report on Ototoxicity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Maximizing Quality of Life After Cancer Through Rehabilitation TIMELY REHAB - Head and Neck Cancer, Hearing Loss | Not applicable | Not yet recruiting | VA Office of Research and Development | 74 | 2027-03-01 | 2026-06-03 |
| OCCUPATIONAL NOISE AND CHEMICAL EXPOSURE EFFECTS ON AUDITORY AND VESTIBULAR FUNCTION Occupational Noise Exposure | Not yet recruiting | Ondokuz Mayıs University | 50 | 2026-09-03 | 2026-09-08 | |
| SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss SPI-1005 Low Dose, SPI-1005 Middle Dose, SPI-1005 High Dose - Lung Cancer, Head and Neck Cancer | Phase 2 | Withdrawn | Sound Pharmaceuticals, Incorporated | 2026-06-01 | 2026-06-03 | |
| Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer Ototoxic Hearing Loss, Ototoxicity, Drug-Induced | Recruiting | Simon Jäger | 55 | 2026-01-20 | 2026-10-20 | |
| Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin ORC-13661, Placebo - Ototoxicity, Drug-Induced | Phase 2 | Recruiting | Kevin Winthrop | 105 | 2025-06-02 | 2026-10-01 |
| Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young Adulthood Audiogram - Ototoxicity, Drug-Induced, Ototoxicity, Radiation-Induced | Not applicable | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 500 | 2025-05-01 | 2025-05-04 |
| Protective Effect of Acetylcysteine Against Cisplatinum-Induced Ototoxicity: A Randomized Controlled Trial Acetyl cysteine, Normal Saline - Cisplatin-induced Ototoxicity, Sensorineural Hearing Loss | Phase 2 | Recruiting | Siriraj Hospital | 40 | 2024-12-23 | 2026-01-23 |
| Long Term Outcomes After Vestibular Implantation Labyrinth Devices MVI™ Multichannel Vestibular Implant System - Bilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency | Not applicable | Recruiting | Johns Hopkins University | 32 | 2024-12-01 | 2026-03-09 |
| The Effect of Cancer Treatments on Speech Perception in Noise, Cognition, and Hearing-Related Quality of Life Chemotherapy, chemoradiation, radiation therapy - Cancer, Hearing Loss Ototoxic | Recruiting | Turku University Hospital | 250 | 2024-10-02 | 2025-04-16 | |
| Statins Effect on Incidence of Side Effects of Platinum Based Chemotherapy Statin - Solid Tumors, Ototoxicity | Phase 1 / Phase 2 | Completed | Minia University | 56 | 2024-09-01 | 2026-01-20 |
| Diagnostic of Various Ototoxicity Induced by Cancer Treatment Auditory, vestibular and electrophysiological investigations, Biologic investigations; seric proteins - Ototoxicity, Drug-Induced | Recruiting | Direction Centrale du Service de Santé des Armées | 540 | 2024-06-19 | 2024-07-08 | |
| Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients N acetyl cysteine - Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity | Phase 2 | Unknown | Ain Shams University | 60 | 2024-02-01 | 2024-03-07 |
| Comparative Study of the Quality of Life of Patients Suffering From OTOTOXICITY Due to Chemotherapy Based on Platinum Salts Fitted With a Hearing Aid Compared to Those Not Fitted. Patients suffering from chemotherapy-induced ototoxicity, Patients suffring from chemotherapy-induced ototoxicity wearing hearing aids - Cancer, Ototoxicity, Drug-Induced | Not applicable | Recruiting | Institut de Cancérologie de Lorraine | 52 | 2024-01-04 | 2026-09-01 |
| Head and Neck Cancer Survivorship Ototoxicity Screening (SOS) Ototoxicity Screening Protocol - Head and Neck Cancer Survivors, Cancer of the Head and Neck Surviors | Not applicable | Completed | Washington University School of Medicine | 55 | 2023-06-06 | 2026-01-12 |
| Vestibular Implantation in Older Adults Labyrinth Devices MVI™ Multichannel Vestibular Implant System - Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD) | Not applicable | Recruiting | Johns Hopkins University | 15 | 2023-04-11 | 2026-01-12 |
| Association Between Tinnitus and Hearing Loss in Locally Advanced Head and Neck Cancer Treated by Radiotherapy Alone or With Chemotherapy: a Prospective and Multicenter Study Head Cancer, Neck Cancer | Recruiting | Assistance Publique - Hôpitaux de Paris | 140 | 2023-03-09 | 2026-08-13 | |
| Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy Sodium Thiosulfate - Ototoxicity, Drug-Induced | Early Phase 1 | Suspended | Children's Hospital Medical Center, Cincinnati | 33 | 2023-03-01 | 2025-10-20 |
| Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction Labyrinth Devices MVI™ Multichannel Vestibular Implant System - Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD) | Not applicable | Recruiting | Johns Hopkins University | 8 | 2023-02-28 | 2026-01-12 |
| Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma Stereotactic radiosurgery - Vestibular Schwannoma, Ototoxicity | Recruiting | University Hospital, Geneva | 258 | 2023-01-24 | 2025-01-13 | |
| Screening for Hearing Loss After Childhood Cancer Hearing test - Childhood Cancer, Hearing Loss | Not applicable | Completed | University of Bern | 476 | 2022-07-05 | 2026-04-14 |
Showing 20 of 49. Sign in to see all of them.
Hearing Loss (18) · Neoplasms (7) · Head and Neck Neoplasms (6) · Tinnitus (6) · Dizziness (5) · Vestibular Diseases (5) · Bilateral Vestibulopathy (4) · Dysequilibrium syndrome (4) · Labyrinth Diseases (4) · Sensation Disorders (4) · Deafness (3) · Hearing Loss, Sensorineural (3) · Hepatoblastoma (3) · Central Nervous System Neoplasms (2)
Chemically-Induced Disorders (49) · Ear Diseases (49) · Otorhinolaryngologic Diseases (49) · Pathologic Processes (49) · Pathological Conditions, Signs and Symptoms (49) · Wounds and Injuries (49) · Drug-Related Side Effects and Adverse Reactions (48) · Radiation Injuries (48) · Nervous System Diseases (31) · Neurologic Manifestations (27) · Signs and Symptoms (27) · Sensation Disorders (23) · Hearing Disorders (22) · Neoplasms (12) · Neoplasms by Site (11)
Acetylcysteine (6) · Cisplatin (4) · sodium thiosulfate (4) · Chemotherapy, Adjuvant (2) · Hearing Tests (2) · Methotrexate (2) · ebselen (2) · Aspirin (1) · Atorvastatin (1) · Audiometry (1) · Calcium Dobesilate (1) · Carboplatin (1) · Chemoradiotherapy (1) · Ciprofloxacin (1) · Control Groups (1)
Johns Hopkins University (4) · Assistance Publique - Hôpitaux de Paris (2) · Children's Oncology Group (2) · Sound Pharmaceuticals, Incorporated (2) · TC Erciyes University (2) · VA Office of Research and Development (2) · Aaron Moberly (1) · Ain Shams University (1) · Cairo University (1) · Centre Hospitalier Universitaire Saint Pierre (1) · Children's Cancer and Leukaemia Group (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Decibel Therapeutics (1) · Direction Centrale du Service de Santé des Armées (1)
United States (19) · France (5) · Canada (4) · Turkey (Türkiye) (4) · Australia (3) · Egypt (3) · United Kingdom (3) · Brazil (2) · Israel (2) · Switzerland (2) · Belgium (1) · Chile (1) · Finland (1) · Germany (1) · Indonesia (1)
John P Carey, MD (3) · Dawn L Konrad-Martin, PhD (2) · Jonathan Kil, MD (2) · Aaron Moberly, MD (1) · Aya T Moustafa, BSc (1) · Benji Crane (1) · Brice Fresneau, MD, PhD (1) · Bulent Tokgoz, MD (1) · Carlos CP Oliveira (1) · Chris Nutting (1) · Claudia Kuehni, MD (1) · Dalia F. Mohammed Fahim, PhD (1) · Dalia S Elhelw, PhD (1) · David Lee, M.D. (1) · David R. Freyer, DO, MS (1)
PMID 31723056, PMID 10459293, PMID 17450108, PMID 21551083, PMID 23557866, PMID 25073872, PMID 27914822, PMID 29445029, PMID 29924955, PMID 30112115, PMID 33677616, PMID 36624598, PMID 40179545, PMID 40397950, PMID 41943511, PMID 41965725
U01DC019364 (2), R01AG076701 (1), R01DC013536 (1), U01DC020175 (1)