322 completed, 190 unknown, 151 recruiting, 56 terminated. 260 Not applicable, 166 Phase 2, 91 Phase 3, 49 Phase 1, 19 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study Clinical Decision Aid, Standard Care - Heart Failure, Coronary Artery Disease | Not yet recruiting | Medical College of Wisconsin | 60 | 2027-12-01 | 2026-11-03 | |
| Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy Osteoradionecrosis, Radiotherapy | Not yet recruiting | AO Innovation Translation Center | 1000 | 2027-03-01 | 2026-09-23 | |
| Maximizing Quality of Life After Cancer Through Rehabilitation TIMELY REHAB - Head and Neck Cancer, Hearing Loss | Not applicable | Not yet recruiting | VA Office of Research and Development | 74 | 2027-03-01 | 2026-06-03 |
| Platelet-Rich Fibrin for Preventing Osteoradionecrosis After Dental Extractions Platelet-rich fibrin (PRF), Standard Dental Extraction Care - Osteoradionecrosis of the Jaw | Not applicable | Not yet recruiting | University of Manitoba | 112 | 2027-01-01 | 2026-10-05 |
| Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer (NSCLC) PET/CT 18F-Flurpiridaz Rest/Stress Test, Coronary CT Angiography (CCTA), 18F-Flurpiridaz - Non Small Cell Lung Cancer, Cardiotoxicity | Phase 2 | Recruiting | Indiana University | 10 | 2027-01-01 | 2026-11-10 |
| PRISM Trial: Partial Breast Versus Whole Breast Radiation in Early Breast Cancer Ultra-Hypofractionated Partial Breast Irradiation, Ultra-Hypofractionated Whole Breast Irradiation - Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Not applicable | Not yet recruiting | Jinnah Postgraduate Medical Centre | 100 | 2026-12-01 | 2026-10-23 |
| The Impact of Using Nicorandil for the Prevention of Doxorubicin-Induced Cardiotoxicity Nicorandil Oral Tablet, Adriamycin (Doxorubicin) - Doxorubicin Induced Cardiotoxicity, Doxorubicin Induced Cardiomyopathy | Phase 2 | Not yet recruiting | Universiti Sains Malaysia | 146 | 2026-12-01 | 2026-11-03 |
| The CARDIOPROTECT Trial Dexrazoxane, Dexrazoxane placebo, Doxorubicin - Diffuse Large B-cell Lymphoma (DLBCL), Cardiotoxicity | Phase 2 | Not yet recruiting | Beth Israel Deaconess Medical Center | 60 | 2026-12-01 | 2026-11-06 |
| Monitoring for CardioToxicity Using WeArable deVices While Undergoing cancEr Treatments (MCT-WAVE) Mobile Cardiac Telemetry, Wearable Cardiac Monitor - Cardiotoxicity, Cancer | Not applicable | Not yet recruiting | University of Minnesota | 72 | 2026-12-01 | 2026-11-02 |
| Thalidomide for Preventing Radiation-Induced Dermatitis in Breast Cancer Patients Thalidomide tablets, Standard supportive care - Radiodermatitis, Breast Neoplasms | Not applicable | Recruiting | First Affiliated Hospital of Guangxi Medical University | 68 | 2026-11-12 | 2026-11-12 |
| Determinants of Radiation Dermatitis in Head and Neck Cancer Patients Receiving Preventive Photobiomodulation Preventive photobiomodulation, External beam radiotherapy, Functional, quality-of-life and photographic assessments - Head and Neck Neoplasms, Radiodermatitis | Not yet recruiting | Hopital Forcilles | 150 | 2026-11-02 | 2026-10-28 | |
| Positron Emission Tomography (PET) Imaging of Chemotherapy-Induced Cardiotoxicity 68Ga-Galmydar, PET/MRI, 18F-FDG - Lymphoma Cancer, Breast Cancer | Phase 1 | Not yet recruiting | Washington University School of Medicine | 36 | 2026-11-01 | 2026-09-24 |
| Oral Care Program for Mouth Side Effects During Head and Neck Radiation Therapy ORAL CARE PRODUCT KIT - Head and Neck Cancer (H&N), Oral Mucositis (Ulcerative) Due to Radiation | Not applicable | Not yet recruiting | UNCANCER LLC | 50 | 2026-11-01 | 2026-10-21 |
| Artificial Intelligence Powered Digital Education Based on the Neuman Systems Model for Breast Cancer Patients Receiving Radiotherap Neuman-Based AI-Supported Digital Education Program, Standard Care (in control arm) - Breast Cancer, Radiodermatitis | Not applicable | Not yet recruiting | Ataturk University | 38 | 2026-11-01 | 2026-10-28 |
| Risk-Adapted Segmental Esophagus-Sparing Radiotherapy for Definitive Non-Small Cell Lung Cancer Risk-Adapted Segmental Esophagus-Sparing IMRT/VMAT, Standard IMRT/VMAT Without Active Esophageal Avoidance - Non-Small Cell Lung Cancer | Phase 3 | Not yet recruiting | Ruijin Hospital | 140 | 2026-10-30 | 2026-11-02 |
| Cardiac Biomarkers in Patients Receiving Immune Checkpoint Inhibitors (PRIME-ICI) Cardiotoxicity, Cardiac Biomarkers | Not yet recruiting | South Tees Hospitals NHS Foundation Trust | 300 | 2026-10-12 | 2026-10-08 | |
| OCTA Evaluated the Efficacy of Glucocorticoid Retrobulbar Injection in Retinal Photo-injury retrobulbar injection of glucocorticoid - Retinal Light Damage, Photic Retinopathy | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 50 | 2026-10-09 | 2026-10-09 | |
| Cardioprotection Effect of Linagliptin Doxorubicin, Empaglifloz 5 mg orally once daily - Cardiotoxicity | Phase 3 | Not yet recruiting | Tanta University | 140 | 2026-10-01 | 2026-10-15 |
| Oral or Topical Catechins for Radiation Dermatitis Epicatechin, Epigallocatechin Gallate (EGCG), Microcrystalline Cellulose NF (placebo) - Radiation Dermatitis Acute, Radiation Dermatitis | Phase 3 | Enrolling by invitation | CARLOS FRANCISCO SAAVEDRA GARCIA | 162 | 2026-10-01 | 2026-09-11 |
| An App to Identify Radiation Pneumonitis - a Pre-Study in Healthy Volunteers PneumoCheck app - Lung Cancer | Not applicable | Not yet recruiting | University Hospital Schleswig-Holstein | 30 | 2026-09-28 | 2026-09-17 |
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Cardiotoxicity (257) · Breast Neoplasms (203) · Radiodermatitis (127) · Head and Neck Neoplasms (84) · Neoplasms (84) · Ototoxicity (49) · Heart Failure (45) · Lung Neoplasms (40) · Radiation Pneumonitis (39) · Prostatic Neoplasms (31) · Carcinoma, Non-Small-Cell Lung (30) · Lymphoma (24) · Brain Neoplasms (23) · Osteoradionecrosis (20)
Wounds and Injuries (834) · Neoplasms (470) · Neoplasms by Site (453) · Pathological Conditions, Signs and Symptoms (405) · Pathologic Processes (383) · Chemically-Induced Disorders (329) · Drug-Related Side Effects and Adverse Reactions (310) · Skin and Connective Tissue Diseases (280) · Skin Diseases (277) · Cardiovascular Diseases (256) · Heart Diseases (255) · Breast Diseases (204) · Dermatitis (119) · Neoplasms by Histologic Type (104)
Radiotherapy (53) · Cisplatin (20) · Doxorubicin (20) · Echocardiography (18) · Cyclophosphamide (12) · Radiotherapy, Intensity-Modulated (12) · Amifostine (11) · Dexrazoxane (10) · Low-Level Light Therapy (10) · Standard of Care (10) · Exercise (9) · Paclitaxel (9) · Radiosurgery (9) · Blood Specimen Collection (8) · Carboplatin (8)
Radiation Therapy Oncology Group (16) · Wake Forest University Health Sciences (14) · Abramson Cancer Center at Penn Medicine (11) · National Cancer Institute (NCI) (9) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (9) · University of Aarhus (9) · West China Hospital (9) · Assistance Publique - Hôpitaux de Paris (8) · Mayo Clinic (8) · Royal Marsden NHS Foundation Trust (8) · Sunnybrook Health Sciences Centre (8) · Ain Shams University (7) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (7) · Children's Oncology Group (7) · AHS Cancer Control Alberta (6)
United States (222) · China (96) · Canada (70) · France (54) · United Kingdom (39) · Egypt (29) · Italy (29) · Brazil (26) · Denmark (26) · Spain (23) · Netherlands (19) · Belgium (18) · Turkey (Türkiye) (16) · Australia (15) · Israel (15)
Bonnie Ky, MD, MSCE (6) · Xingchen Peng (5) · Edward LW Chow, MBBS (4) · Bernardino Clavo, MD, PhD (3) · Cafer Zorkun, MD PhD (3) · Jingfang Mao, PHD (3) · John P Carey, MD (3) · John R. Yarnold, MD, FRCR (3) · Marielle Scherrer-Crosbie, MD, PhD (3) · Scott Okuno, MD (3) · Aminah Jatoi, MD (2) · Anthony Yu, MD (2) · Benjamin Movsas, MD (2) · Chris Nutting (2) · Cindy Schwartz, MD (2)
PMID 31723056, PMID 15992242, PMID 22105041, PMID 23102757, PMID 23215625, PMID 26357522, PMID 30271455, PMID 32379556, PMID 33738491, PMID 36207229, PMID 42032732, PMID 10071296, PMID 10443466, PMID 10459293, PMID 10761937, PMID 11173128, PMID 11263649, PMID 11744442, PMID 11901547, PMID 11913479, PMID 11917283, PMID 12011138, PMID 12800204, PMID 12948221, PMID 13211322, PMID 14349898, PMID 14566480, PMID 15050309, PMID 15183474, PMID 15222781, PMID 15473335, PMID 15477280, PMID 15480814, PMID 15800308, PMID 15812073, PMID 16015544, PMID 16027437, PMID 16131888, PMID 16332601, PMID 16549835, PMID 16568436, PMID 16823067, PMID 16841333, PMID 16893745, PMID 16980242, PMID 17047036, PMID 17050868, PMID 17068719, PMID 17293228, PMID 17336213
2023 (5), P30CA012197 (5), U10CA081851 (4), 2018 (2), P30CA015083 (2), P30CA068485 (2), U01DC019364 (2), U01DE022939 (2), 2009 (1), 2014 (1), 2016 (1), 2019 (1), I01CX000569 (1), K08CA259626 (1), N01CM62202 (1)