69 completed, 51 unknown, 43 recruiting, 18 not yet recruiting. 102 Not applicable, 10 Phase 1, 8 Phase 2, 7 Phase 4, 3 Phase 3.
Follow Mitral Regurgitation: new trials by email Literature Review of Mitral Regurgitation trials Research Report on Mitral Regurgitation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| The PALMETTO Study ReValve System - Mitral Regurgitation | Not applicable | Not yet recruiting | ReValve Solutions Inc. | 10 | 2026-11-01 | 2026-10-21 |
| Anchord Mitral Chordal Repair System - FIH Anchord device implantation - Mitral Regurgitation | Not applicable | Not yet recruiting | Lifecord Otd | 5 | 2026-10-01 | 2026-09-04 |
| LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY Mitral valve repair with creation of an 8 mm inter-atrial shunt - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Ottawa Heart Institute Research Corporation | 50 | 2026-09-30 | 2026-05-06 |
| EFS of Posterior Leaflet Replacement to Reduce Mitral Regurgitation (United States) MR-ace Implant and Delivery System - Mitral Regurgitation | Not applicable | Recruiting | Polares Medical SA | 15 | 2026-09-01 | 2026-09-01 |
| The REValve Clinical Trial an Evaluation Of the ReValve Palmetto Valve for the Replacement of the Native Mitral VaLVE ReValve System - Mitral Regurgitation | Phase 1 | Recruiting | ReValve Solutions Inc. | 20 | 2026-09-01 | 2026-09-29 |
| Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US) Mitral Valve Replacement - Mitral Regurgitation, Heart Disease | Not applicable | Recruiting | InnovHeart | 15 | 2026-08-05 | 2026-08-10 |
| Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE) Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.) - Valvular Heart Disease Patients, Aortic Stenosis | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 1088 | 2026-08-01 | 2026-08-17 |
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation Aortic Stenosis, Mitral Regurgitation | Not yet recruiting | Josep Rodes-Cabau | 300 | 2026-06-05 | 2026-06-03 | |
| Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty - Aortic Stenosis, Aortic Regurgitation | Not yet recruiting | Beijing Anzhen Hospital | 5500 | 2026-05-10 | 2026-05-26 | |
| MITRAClip GENeration 5 Mitral Valve Transcatheter Edge-to-Edge Repair Registry MitraClip G5 - Mitral Regurgitation | Not yet recruiting | University Hospital of Cologne | 1000 | 2026-05-01 | 2026-05-01 | |
| A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR. GeminiOne Transcatheter Edge-to-Edge Repair (TEER) System - Mitral Regurgitation | Not applicable | Recruiting | Sierra Valve LLC | 15 | 2026-03-26 | 2026-04-24 |
| The EMBRACE Registry: European Post-Market Registry for Catheter Based Mitral Valve Replacement Mitral Regurgitation | Not yet recruiting | HighLife SAS | 150 | 2026-03-14 | 2026-02-13 | |
| Study for the Identification of Subclinical Atrial Fibrillation In Patients With Significant Primary Mitral Regurgitation Mitral Regurgitation, Atrial Fibrillation (AF) | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 100 | 2026-02-01 | 2026-02-02 | |
| Combined Mitral and Tricuspid Versus Isolated Mitral Transcatheter Edge-to-Edge Repair for Mitral Regurgitation With Tricuspid Regurgitation (DUAL-TEER Trial) Transcatheter Edge-to-Edge Repair (TEER) System - Mitral Regurgitation, Tricuspid Regurgitation | Not applicable | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 404 | 2026-02-01 | 2026-01-20 |
| The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation mitral valve surgery, Clinical Follow up - Mitral Valve Prolapse, Mitral Regurgitation | Not applicable | Active not recruiting | Centro Cardiologico Monzino | 260 | 2025-12-01 | 2026-06-10 |
| Additive Prognostic Value of PALS Compared to Bernard's Staging in Patients Undergoing MV Surgery Speckle tracking and 2D echocardiography - Mitral Regurgitation | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 300 | 2025-09-15 | 2025-09-03 | |
| Artificial Intelligence Assisting Transcatheter Mitral Edge-to-Edge Repair Mitral Regurgitation | Active not recruiting | Mi Chen | 1500 | 2025-09-01 | 2026-06-08 | |
| Abbott Cephea Mitral Valve Disease Registry Mitral Regurgitation, Mitral Stenosis | Recruiting | Abbott Medical Devices | 1000 | 2025-08-13 | 2026-09-10 | |
| STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant Experimental: Aspirin monotherapy, Active Comparator: Aspirin+Clopidogrel - Mitral Regurgitation | Phase 4 | Recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 1032 | 2025-07-31 | 2026-03-09 |
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Mitral Valve Insufficiency (217) · Heart Failure (33) · Heart Valve Diseases (17) · Tricuspid Valve Insufficiency (15) · Aortic Valve Stenosis (14) · Mitral Valve Prolapse (13) · Mitral Valve Stenosis (10) · Coronary Artery Disease (9) · Aortic Valve Insufficiency (8) · Myocardial Infarction (8) · Cardiovascular Diseases (7) · Heart Diseases (7) · Atrial Fibrillation (6) · Disease (4) · Gastroesophageal Reflux (3)
Cardiovascular Diseases (210) · Heart Diseases (210) · Heart Valve Diseases (200) · Pathological Conditions, Signs and Symptoms (25) · Pathologic Processes (20) · Aortic Valve Disease (18) · Vascular Diseases (17) · Ventricular Outflow Obstruction (14) · Heart Valve Prolapse (13) · Myocardial Ischemia (13) · Arterial Occlusive Diseases (9) · Arteriosclerosis (9) · Coronary Disease (9) · Infarction (9) · Ischemia (9)
Mitral Valve Annuloplasty (8) · Drug Delivery Systems (4) · Hydroxyethyl Starch Derivatives (3) · Mutagenesis, Insertional (3) · Adrenergic beta-Antagonists (2) · Metoprolol (2) · Angiotensin-Converting Enzyme Inhibitors (1) · Angptl4 protein, mouse (1) · Blood Cell Count (1) · Blood Specimen Collection (1) · Bupivacaine (1) · Cardiac Catheterization (1) · Cardiac Surgical Procedures (1) · Echocardiography (1) · Exercise Test (1)
Abbott Medical Devices (18) · Edwards Lifesciences (12) · Michele De Bonis (6) · Viacor (5) · Cardiovalve Ltd. (4) · HighLife SAS (4) · Konkuk University Medical Center (4) · Medical University of Vienna (4) · Imperial College London (3) · LMU Klinikum (3) · Mayo Clinic (3) · Ottawa Heart Institute Research Corporation (3) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (3) · 4C Medical Technologies, Inc. (2) · Abby Geerlings (2)
United States (59) · Germany (37) · Italy (32) · China (23) · Canada (18) · Netherlands (16) · United Kingdom (16) · France (13) · Switzerland (13) · Austria (9) · Poland (9) · Greece (8) · Israel (8) · Spain (8) · Australia (7)
Vinod Thourani, MD (4) · Mayra Guerrero, MD (3) · Ted Feldman, M.D. (3) · Annalisa Pasquini, MD, PhD (2) · Barathi Sethuraman (2) · JoAnn Lindenfeld, MD (2) · Joerg Hausleiter, MD (2) · Luc Bilodeau, MD (2) · Malte Kelm, MD (2) · Michael Mack, MD (2) · Paul Sorajja, MD (2) · Rainer Hoffmann, MD (2) · William T Abraham, MD (2) · Xiangbin Pan, MD,PhD (2)
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2025 (1), K23HL177311 (1)