12 completed, 3 unknown, 2 recruiting, 2 terminated. 19 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 12, Unknown 3, Recruiting 2, Terminated 2 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
Follow Migraine with Aura: new trials by email Literature Review of Migraine with Aura trials Research Report on Migraine with Aura
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of EVO756 in Adults With Migraine EVO756, Dose 1, EVO756, Dose 2, Placebo - Migraine | Phase 2 | Recruiting | Evommune, Inc. | 330 | 2026-07-29 | 2026-11-04 |
| A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine TNX-1900, Placebo Nasal Spray - Chronic Migraine, Chronic Migraine, Headache | Phase 2 | Completed | Tonix Pharmaceuticals, Inc. | 88 | 2022-12-06 | 2025-02-25 |
| Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura Amiloride, Placebos - Migraine With Aura | Phase 2 | Recruiting | Centre Hospitalier Universitaire de Nice | 40 | 2020-08-11 | 2025-12-04 |
| Can DFN-15 Terminate Migraine With Allodynia? DFN-15, Placebo - Migraine With Aura, Migraine Without Aura | Phase 2 | Completed | Hartford Hospital | 51 | 2018-05-09 | 2019-04-16 |
| Treatment of Chronic Migraine Headaches. Dexamethasone, Lidocaine, Thiamine cohort - Chronic Migraine Without Aura, Intractable, Migraine With Typical Aura | Phase 1 / Phase 2 | Unknown | Corona Doctors Medical Clinics, Inc. | 100 | 2017-07-01 | 2018-04-04 |
| Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine Naltrexone and Acetaminophen, Naltrexone and Acetaminophen-High Dose, Naltrexone Alone (regular dose) - Migraine With or Without Aura | Phase 2 | Completed | Allodynic Therapeutics, Inc | 92 | 2017-02-18 | 2021-04-14 |
| Botox Injection in Treatment of Chronic Migraine Botulinum Toxin Type A - Migraine Disorders | Phase 1 / Phase 2 | Completed | Norwegian University of Science and Technology | 10 | 2015-02-01 | 2016-05-23 |
| Study of NXN 188 for the Treatment of Migraine With Aura NXN-188, placebo, sumatriptan succinate - Migraine With Aura | Phase 2 | Completed | NeurAxon Inc. | 239 | 2009-06-01 | 2014-08-11 |
| Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura NXN-188, Placebo - Migraine With Aura | Phase 2 | Unknown | Danish Headache Center | 40 | 2009-05-01 | 2009-07-28 |
| Candesartan Versus Propranolol for Migraine Prevention Candesartan, propranolol, placebo - Migraine Without Aura, Migraine With Aura | Phase 2 / Phase 3 | Completed | Norwegian University of Science and Technology | 72 | 2009-04-01 | 2013-12-24 |
| A Study of a Melatonin Receptor Agonist to Prevent Migraine Ramelteon, Placebo - Migraine, Migraine With Aura | Phase 2 | Terminated | Swedish Medical Center | 18 | 2008-04-01 | 2012-08-23 |
| Dose Ranging Study of the Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache Tonabersat, Placebo - Migraine Without Aura, Migraine With Aura | Phase 2 | Completed | Minster Research Ltd | 542 | 2007-10-01 | 2009-03-31 |
| Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine AST-726 Low dose, AST-726 High dose, AST-726 Placebo - Migraine, Migraine Headache | Phase 2 | Unknown | Ariston Pharmaceuticals, Inc. | 198 | 2007-05-01 | 2008-02-08 |
| PRIMA PFO Migraine Trial AMPLATZER® PFO Occluder Device - Migraine, Migraine With Aura | Phase 2 | Terminated | Abbott Medical Devices | 107 | 2006-05-01 | 2019-02-04 |
| Tonabersat in the Prophylaxis of Migraine With Aura Tonabersat, Placebo - Migraine With Aura | Phase 2 | Completed | Minster Research Ltd | 39 | 2006-05-01 | 2009-08-31 |
| Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache Tonabersat, Placebo - Migraine Without Aura, Migraine With Aura | Phase 2 | Completed | Minster Research Ltd | 124 | 2006-04-01 | 2009-08-31 |
| Study to Evaluate the Efficacy and Safety of Dronabinol Metered Dose Inhaler (MDI) in Acute Treatment of Migraine Headache Dronabinol MDI - Migraine With Aura, Migraine Without Aura | Phase 2 | Completed | Solvay Pharmaceuticals | 2005-09-01 | 2015-01-16 | |
| Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Topiramate - Basilar Migraine | Phase 2 / Phase 3 | Completed | Monarch Medical Research | 40 | 2004-02-01 | 2012-11-12 |
| A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Topiramate - Basilar Migraine | Phase 2 | Completed | Monarch Medical Research | 40 | 2004-02-01 | 2007-04-05 |
Migraine Disorders (12) · Migraine without Aura (10) · Epilepsy (3) · Headache (3) · Headache Disorders (2) · Foramen Ovale, Patent (1) · Hyperalgesia (1)
Brain Diseases (19) · Central Nervous System Diseases (19) · Headache Disorders, Primary (19) · Nervous System Diseases (19) · Headache Disorders (17) · Migraine Disorders (7) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Pain (3) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Heart Defects, Congenital (1)
tonabersat (3) · Topiramate (2) · Acetaminophen (1) · Amiloride (1) · Botulinum Toxins, Type A (1) · Celecoxib (1) · Dexamethasone (1) · Lidocaine (1) · Naltrexone (1) · Propranolol (1) · Sumatriptan (1) · candesartan (1) · ramelteon (1)
Minster Research Ltd (3) · Monarch Medical Research (2) · Norwegian University of Science and Technology (2) · Abbott Medical Devices (1) · Allodynic Therapeutics, Inc (1) · Ariston Pharmaceuticals, Inc. (1) · Centre Hospitalier Universitaire de Nice (1) · Corona Doctors Medical Clinics, Inc. (1) · Danish Headache Center (1) · Evommune, Inc. (1) · Hartford Hospital (1) · NeurAxon Inc. (1) · Solvay Pharmaceuticals (1) · Swedish Medical Center (1) · Tonix Pharmaceuticals, Inc. (1)
United States (10) · Denmark (3) · United Kingdom (3) · Canada (2) · Norway (2) · Australia (1) · Finland (1) · France (1) · Germany (1) · Hungary (1) · Netherlands (1) · New Zealand (1) · South Africa (1) · Switzerland (1)
Donald W Lewis, MD (2) · Annette C Toledano, M.D. (1) · Erling A Tronvik, PhD, MD (1) · Faro T. Owiesy, M.D. (1) · Gregory Sullivan, MD (1) · Guy Boudreau, MD (1) · Jes Olesen, MD (1) · Lars J Stovner, Ph.D. (1) · Peer Tfelt-Hansen, MD, Dr Med Sci (1) · Peter Goadsby, MD (1) · Richard Lipton, MD (1) · Sheena K Aurora, MD (1)
PMID 11112243, PMID 16135345, PMID 16450381, PMID 16611468, PMID 17175134, PMID 18662331, PMID 19222510, PMID 19453963, PMID 19570717, PMID 20548058, PMID 22520687, PMID 24335848, PMID 25744676, PMID 26603732, PMID 26908949, PMID 27154997, PMID 28322750, PMID 29310498
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