37 completed, 7 unknown, 4 recruiting, 4 terminated. 14 Phase 4, 12 Phase 2, 12 Phase 3, 8 Not applicable, 5 Phase 1.
Follow Amiloride: new trials by email Literature Review of Amiloride trials Research Report on Amiloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer ARX788, Computed Tomography (CT), Biospecimen Collection - HER2 Low Breast Carcinoma, Triple Negative Breast Cancer | Phase 2 | Recruiting | Laura Huppert, MD, BA | 36 | 2026-06-05 | 2026-06-11 |
| Beneficial Effect of Amiloride on Progression of Chronic Kidney Disease amiloride, Placebo - Chronic Kidney Disease(CKD), Proteinuria | Phase 2 | Recruiting | Odense University Hospital | 40 | 2024-10-10 | 2025-04-11 |
| Mechanisms of Diuretic Resistance in Heart Failure, Aim 2 Placebo, Amiloride, Bendroflumethiazide - Heart Failure | Phase 1 | Recruiting | Yale University | 50 | 2023-08-10 | 2026-09-08 |
| AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium Anhydrous Amiloride Hydrochloride, Placebo - Bipolar Disorder | Phase 4 | Active not recruiting | Assistance Publique - Hôpitaux de Paris | 148 | 2023-01-11 | 2025-05-09 |
| Treatment of Vascular Stiffness in ADPKD Sodium chloride (NaCl), Placebo, Amiloride Hcl 5mg Tab - Autosomal Dominant Polycystic Kidney | Phase 4 | Completed | Erasmus Medical Center | 46 | 2022-03-11 | 2025-08-17 |
| Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene Amiloride, Triamterene - Hypertension | Completed | Brigham and Women's Hospital | 155963 | 2021-10-01 | 2025-11-06 | |
| Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension Spironolactone, Amiloride - Resistant Hypertension | Phase 4 | Completed | Yonsei University | 118 | 2020-11-16 | 2024-09-24 |
| Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers Amiloride - Pharmacokinetics | Early Phase 1 | Completed | University of Utah | 15 | 2020-09-28 | 2023-03-08 |
| Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura Amiloride, Placebos - Migraine With Aura | Phase 2 | Recruiting | Centre Hospitalier Universitaire de Nice | 40 | 2020-08-11 | 2025-12-04 |
| Amiloride in Nephrotic Syndrome Amiloride, Furosemide - Nephrotic Syndrome, Edema | Phase 3 | Terminated | University Hospital Tuebingen | 20 | 2020-06-08 | 2025-01-14 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension. Chlorthalidone 25 mg, Hydrochlorothiazide 50 mg, Amiloride 20 mg - Hypertension | Phase 3 | Unknown | Hospital de Clinicas de Porto Alegre | 84 | 2019-11-13 | 2019-12-09 |
| ENAC Blockade and Arterial Stiffness Placebo - Cap, Amiloride Pill - Overweight and Obesity, Insulin Resistance | Phase 2 / Phase 3 | Completed | University of Missouri-Columbia | 137 | 2019-07-15 | 2025-12-30 |
| Natriuretic Effect of Amiloride in Relation to the Alpha Adducin Gene (ADD-AMI) RS4961 Variant Amiloride - Hypertension Essential, Salt Excess | Phase 3 | Completed | Ospedale San Raffaele | 40 | 2018-09-28 | 2024-05-16 |
| A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein Amiloride, Hydrochlorothiazide - Chronic Kidney Diseases | Phase 4 | Completed | Guangdong Provincial People's Hospital | 40 | 2018-03-01 | 2020-09-18 |
| Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism Teriparatide, Thiazide, Potassium sparing diuretic - Autosomal Dominant Hypocalcemia OR Primary Hypoparathyroidism Related to Other Cause But Complicated by Hypercalciuria Under Treatment | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 16 | 2017-06-06 | 2021-06-28 |
| Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions GSK3542503 (HCTZ 50mg/Amiloride HCl 5mg tablets), Moduretic (HCTZ 50mg/Amiloride HCl 5mg tablets) - Hypertension | Phase 1 | Completed | GlaxoSmithKline | 42 | 2017-03-17 | 2021-05-07 |
| Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Adrenalectomy, Mineralocorticoid Receptor Antagonists - Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma | Completed | Changi General Hospital | 57 | 2017-02-20 | 2022-05-20 | |
| Increased Activity of ENaC in Proteinuric Kidney Transplant Recipients Standardized sodium diet, Tbl amiloride - Kidney Transplant; Complications | Not applicable | Completed | University of Southern Denmark | 14 | 2017-01-01 | 2022-12-27 |
| Comparison of Optimal Hypertension Regimens Amlodipine, Lisinopril, Amiloride - Hypertension | Phase 4 | Completed | Cambridge University Hospitals NHS Foundation Trust | 940 | 2016-11-01 | 2025-09-05 |
Showing 20 of 54. Sign in to see all of them.
Hypertension (21) · Proteinuria (4) · Renal Insufficiency, Chronic (4) · Diabetes Mellitus, Type 2 (3) · Albuminuria (2) · Cardiovascular Diseases (2) · Cystic Fibrosis (2) · Essential Hypertension (2) · Prehypertension (2) · Sleep Apnea Syndromes (2) · Attention Deficit Disorder with Hyperactivity (1) · Bipolar Disorder (1) · Bronchitis (1) · Coronary Artery Disease (1) · Coronary Disease (1)
Hospital de Clinicas de Porto Alegre (5) · Assistance Publique - Hôpitaux de Paris (2) · Brigham and Women's Hospital (2) · Erasmus Medical Center (2) · GlaxoSmithKline (2) · Regional Hospital Holstebro (2) · University of Cambridge (2) · University of Carabobo (2) · University of Southern Denmark (2) · University of Utah (2) · Adams Respiratory Therapeutics (1) · Augusta University (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Centre Hospitalier Universitaire de Nice (1) · Changi General Hospital (1)
United States (17) · Brazil (7) · Denmark (7) · United Kingdom (6) · France (4) · Netherlands (2) · Venezuela (2) · China (1) · Germany (1) · India (1) · Italy (1) · Singapore (1) · South Africa (1) · South Korea (1)
Antonio J Delgado-Leon, MD (2) · Antonio R Delgado-Almeida, MD, FAHA, FACC, APS (2) · Carlos L Delgado-Leon, MD (2) · Sandra C Fuchs, MD, PhD (2) · Adam P Bress, PharmD, MS (1) · Adriana C Forti (1) · Agnes Linglart, MD, PhD (1) · Anand Vaidya, MD MMSc (1) · Anne Blanchard, MD, PhD (1) · Boye L Jensen, MD, PhD (1) · Camila Manrique Acevedo, MD (1) · Claus Bistrup, MD, PhD (1)
PMID 38254266, PMID 12479763, PMID 15106785, PMID 16450381, PMID 16611468, PMID 18391085, PMID 20651602, PMID 21423678, PMID 21444835, PMID 21502568, PMID 22842475, PMID 22948302, PMID 24382030, PMID 24410943, PMID 26253567, PMID 26553836, PMID 26938814, PMID 27965209, PMID 28761581, PMID 29172994, PMID 29227377, PMID 29433578, PMID 30092411, PMID 30166303, PMID 31791376, PMID 31843024, PMID 31981516, PMID 31996411, PMID 33047257, PMID 33891615, PMID 33957621, PMID 34164803, PMID 35846272, PMID 35945550, PMID 38781664, PMID 39262426, PMID 39356039, PMID 40366680, PMID 40859651, PMID 42247265, PMID 42669885
2009 (1), 2016 (1), 2019 (1), R01DK130997 (1)